Evaluation of the Novel Centrifugal Pump, CAPIOX SL, in Chronic Large Animal Experiments
This study aimed to evaluate the in vivo performance of the SL pump in the condition assumed severe clinical situation for long‐term extracorporeal membrane oxygenation (ECMO) support. Extracorporeal circulation using the SL pump was installed in three goats, with drainage from the inferior vena cava and infusion into the right jugular artery. The animals were maintained with target pump flow of 2.0–3.0 L/min for 3 or 7 days. Anticoagulation was performed by continuous infusion of heparin with a target activated coagulation time (ACT) of 200 ± 50 s. Blood tests were performed regularly. After 3 or 7 days, autopsie...
Source: Artificial Organs - February 12, 2018 Category: Transplant Surgery Authors: Kei Iizuka, Nobumasa Katagiri, Yoshiaki Takewa, Tomonori Tsukiya, Toshihide Mizuno, Yosuke Itamochi, Kouko Kumano, Eisuke Tatsumi Tags: Thoughts and Progress Source Type: research
Type II Minimal ‐Invasive Extracorporeal Circuit for Aortic Valve Replacement: A Randomized Controlled Trial
Abstract
Extracorporeal circulation triggers systemic inflammatory response and coagulation disorders which may lead to unfavorable clinical outcome. A type II minimally‐invasive extracorporeal circuit (MiECC) is a closed system with markedly reduced artificial surface as compared to conventional extracorporeal circuits (CECC). The aim of this study was to investigate and compare inflammatory responses, complement activation and selected clinical end‐points in isolated surgical aortic valve replacement (SAVR) performed with a type II MiECC circuit or a CECC. Fifty patients were prospectively randomized to MiECC or CECC...
Source: Artificial Organs - February 12, 2018 Category: Transplant Surgery Authors: Erich Gygax, Hans ‐Ulrich Kaeser, Mario Stalder, Brigitta Gahl, Robert Rieben, Thierry Carrel, Gabor Erdoes Tags: Main Text Source Type: research
Changes in Total Cardiac Output and Oxygen Extraction During Exercise in Patients Supported With an HVAD Left Ventricular Assist Device
Abstract
Following implantation of a left ventricular assist device (LVAD), acceptable functional performance is now being achieved; however, peak VO2 and peak work load (watts) remain considerably limited. Maximum physical capacity is essentially dependent on generated cardiac output (CO) and arteriovenous oxygen difference (avDO2). We investigated the changes in CO and avDO2 during exercise in LVAD patients with an HVAD pump (HeartWare Inc., Framingham, MA, USA). Approximately 6 weeks after implantation, 20 patients (100% male, 60.8 ± 7.3 years old, BMI 25.7 ± 3.3) underwent a six‐minute walk test (6MWT), a c...
Source: Artificial Organs - February 12, 2018 Category: Transplant Surgery Authors: Thomas Schmidt, Birna Bjarnason ‐Wehrens, Stephanie Mommertz, Meike Hannig, Sebastian Schulte‐Eistrup, Detlev Willemsen, Nils Reiss Tags: Main Text Source Type: research
Implementing and Assessing a Standardized Protocol for Weaning Children Successfully From Extracorporeal Life Support
Artificial Organs, EarlyView. (Source: Artificial Organs)
Source: Artificial Organs - February 8, 2018 Category: Transplant Surgery Source Type: research
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Artificial Organs, Ahead of Print. (Source: Artificial Organs)
Source: Artificial Organs - February 8, 2018 Category: Transplant Surgery Source Type: research
Hemodynamic Effects of Connection to Continuous Renal Replacement Therapy in a Pediatric Animal Model
Artificial Organs, EarlyView. (Source: Artificial Organs)
Source: Artificial Organs - February 6, 2018 Category: Transplant Surgery Source Type: research
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Artificial Organs, Ahead of Print. (Source: Artificial Organs)
Source: Artificial Organs - February 6, 2018 Category: Transplant Surgery Source Type: research
Heart Transplantation in Patients Supported by ECMO: Is the APACHE IV Score a Predictor of Survival?
Artificial Organs, EarlyView. (Source: Artificial Organs)
Source: Artificial Organs - February 2, 2018 Category: Transplant Surgery Source Type: research
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Artificial Organs, Ahead of Print. (Source: Artificial Organs)
Source: Artificial Organs - February 2, 2018 Category: Transplant Surgery Source Type: research
Ovine Leukocyte Microparticles Generated by the CentriMag Ventricular Assist Device In Vitro
Abstract
Ventricular assist devices (VADs) are a life‐saving form of mechanical circulatory support in heart failure patients. However, VADs have not yet reached their full potential due to the associated side effects (thrombosis, bleeding, infection) related to the activation and damage of blood cells and proteins caused by mechanical stress and foreign materials. Studies of the effects of VADs on leukocytes are limited, yet leukocyte activation and damage including microparticle generation can influence both thrombosis and infection rates. Therefore, the aim was to develop a multicolor flow cytometry assessment of leuk...
Source: Artificial Organs - February 1, 2018 Category: Transplant Surgery Authors: Ina Laura Pieper, Gemma Radley, Abigail Christen, Sabrina Ali, Owen Bodger, Catherine A. Thornton Tags: Main Text Source Type: research
Selective Cerebro ‐Myocardial Perfusion in Complex Neonatal Aortic Arch Pathology: Midterm Results
Abstract
Aortic arch repair in newborns and infants has traditionally been accomplished using a period of deep hypothermic circulatory arrest. To reduce neurologic and cardiac dysfunction related to circulatory arrest and myocardial ischemia during complex aortic arch surgery, an alternative and novel strategy for cerebro‐myocardial protection was recently developed, where regional low‐flow perfusion is combined with controlled and independent coronary perfusion. The aim of the present retrospective study was to assess short‐term and mid‐term results of selective and independent cerebro‐myocardial perfusion in ne...
Source: Artificial Organs - February 1, 2018 Category: Transplant Surgery Authors: Stiljan Hoxha, Riccardo Giuseppe Abbasciano, Camilla Sandrini, Lucia Rossetti, Tiziano Menon, Luca Barozzi, Daniele Linardi, Alessio Rungatscher, Giuseppe Faggian, Giovanni Battista Luciani Tags: Thoughts and Progress Source Type: research
Preclinical In Vitro Safety Investigations of Submicron Sized Hemoglobin Based Oxygen Carrier HbMP ‐700
Abstract
Hemoglobin‐based oxygen carriers (HBOCs) are being developed as oxygen and plasma volume‐expanding therapeutics though their potential to promote oxidative tissue injury and nitric oxide (NO) scavenging combined with vasoconstriction has raised safety concerns. Therefore, we focused on these aspects during preclinical studies performed with the recently introduced hemoglobin microparticles (HbMP‐700). Besides oxidative stress, we investigated possible vasoconstrictory influence of HBOCs as well as genetic toxicity. The novel developed HbMP‐700 presented here provides a high oxygen affinity which prevents p...
Source: Artificial Organs - February 1, 2018 Category: Transplant Surgery Authors: Ijad Kao, Yu Xiong, Axel Steffen, Kathrin Smuda, Lian Zhao, Radostina Georgieva, Axel Pruss, Hans B äumler Tags: Main Text Source Type: research
Contemporary Oxygenator Design: Shear Stress ‐Related Oxygen and Carbon Dioxide Transfer
Abstract
Design of contemporary oxygenators requires better understanding of the influence of hydrodynamic patterns on gas exchange. A decrease in blood path width or an increase in intraoxygenator turbulence for instance, might increase gas transfer efficiency but it will increase shear stress as well. The aim of this clinical study was to examine the association between shear stress and oxygen and carbon dioxide transfer in different contemporary oxygenators during cardiopulmonary bypass (CPB). The effect of additional parameters related to gas transfer efficiency, that is, blood flow, gas flow, sweep gas oxygen fraction...
Source: Artificial Organs - February 1, 2018 Category: Transplant Surgery Authors: Rik H. J. Hendrix, Yuri M. Ganushchak, Patrick W. Weerwind Tags: Main Text Source Type: research
