Contents: Arch. Pharm. Chem. Life Sci. (7/2016)
(Source: Archiv der Pharmazie)
Source: Archiv der Pharmazie - July 3, 2016 Category: Drugs & Pharmacology Tags: Contents Source Type: research
Editorial Board: Arch. Pharm. Chem. Life Sci. (7/2016)
(Source: Archiv der Pharmazie)
Source: Archiv der Pharmazie - July 3, 2016 Category: Drugs & Pharmacology Tags: Editorial Board Source Type: research
Cover Picture: Arch. Pharm. Chem. Life Sci. (7/2016)
(Source: Archiv der Pharmazie)
Source: Archiv der Pharmazie - July 3, 2016 Category: Drugs & Pharmacology Tags: Cover Picture Source Type: research
Synthesis and Biological Evaluation of Novel Bischalcone Derivatives as Carbonic Anhydrase Inhibitors
Design and synthesis of a new type of bischalcones as an alternative to natural and synthetic bischalcones are reported for the first time. Key steps involved the solvent‐free Claisen–Schmidt condensation of chalcones, and the successful first application of the diazotization–diazocoupling reaction in the synthesis of CNNC‐linked bischalcones by simple structural modification of p‐aminoacetophenone. The structures of all compounds were confirmed by means of FT‐IR, 1H and 13C NMR, ESI/MS, and elemental analysis. In addition, the newly synthesized compounds were screened for carbonic anhydrase inhibition...
Source: Archiv der Pharmazie - June 30, 2016 Category: Drugs & Pharmacology Authors: Tayfun Arslan, Gonca Çelik, Habip Çelik, Murat Şentürk, Nurettin Yaylı, Deniz Ekinci Tags: Full Paper Source Type: research
Synthesis and In Vitro Pharmacological Evaluation of 5‐(Alkoxymethyl)‐2‐(3‐alkylamino‐2‐hydroxypropoxy)phenylethanones Related to Acebutolol and Celiprolol
The structure–activity relationships of 13 analogs of aryloxyaminopropanol type derived from 2‐hydroxyphenylethanone as potential β‐blockers are described. The synthesized compounds possess an isopropyl or a tert‐butyl group in the hydrophilic part of the molecule and an alkoxymethyl substitution in the lipophilic moiety. The target compounds were prepared by an established four‐step method and their structures were confirmed by interpretation of their UV, IR, 1H NMR and 13C NMR spectra, and by elemental analysis. The β‐adrenolytic efficacy of the prepared racemic compounds was determined on isolated guinea p...
Source: Archiv der Pharmazie - June 30, 2016 Category: Drugs & Pharmacology Authors: Katarína Bruchatá, Andrej Némethy, Ružena Čižmáriková, Eva Račanská, Ladislav Habala Tags: Full Paper Source Type: research
