Requirement for specific gravity and creatinine adjustments for urinary steroids and luteinizing hormone concentrations in adolescents
Conclusions
Urine steroid and luteinizing hormone concentrations in first morning void samples of adolescents are not significantly influenced by hydration status and may not require adjustments; however, if desired, both creatinine and specific gravity adjustments are equally suitable. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Singh, G. K., Balzer, B. W., Desai, R., Jimenez, M., Steinbeck, K. S., Handelsman, D. J. Tags: Original Articles Source Type: research
Faecal calprotectin as a marker for oesophago-gastric cancer
Conclusion
Faecal calprotectin is elevated in patients with cancer of the upper gastrointestinal tract. This study suggests that calprotectin may be promising in discriminating cancer patients from controls, but further work is required to explore any potential role of faecal calprotectin in screening for, or diagnosis of, oesophago-gastric cancer. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Vincent, Z., Hornby, S., Ball, S., Sanders, G., Ayling, R. M. Tags: Original Articles Source Type: research
Procalcitonin in the assessment of bacteraemia in emergency department patients: results of a large retrospective study
Conclusions
When procalcitonin is used as a serum marker for ruling out bacteraemia, a cut-off of 0.1 ng/mL may be used. Procalcitonin improves the diagnostic accuracy of existing markers of bacteraemia. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Kim, S.-Y., Jeong, T. D., Lee, W., Chun, S., Min, W.-K. Tags: Original Articles Source Type: research
Elastic modulus of low-density lipoprotein as potential indicator of its oxidation
In this study, the effect of low-density lipoprotein oxidation on the low-density lipoprotein stiffness was investigated using an atomic force microscope.
Methods
Isolated low-density lipoprotein particles with or without oxidation were densely bound to an Au substrate on mica, and then pressed and deformed by the atomic force microscope tip. The stiffness of each low-density lipoprotein particle was estimated as the elastic modulus obtained by the force curve analysis. Biochemical change of low-density lipoprotein due to oxidation was studied by electrophoresis.
Results and conclusion
The elastic modulus of low-density ...
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Takeda, S., Subagyo, A., Hui, S.-P., Fuda, H., Shrestha, R., Sueoka, K., Chiba, H. Tags: Original Articles Source Type: research
A rapid anion-exchange chromatography for measurement of cholesterol concentrations in five lipoprotein classes and estimation of lipoprotein profiles in male volunteers without overt diseases
Conclusion
The rapid anion-exchange chromatography assay may be sufficiently applied to the assessment of borderline dyslipidemia. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Manita, D., Hirowatari, Y., Yoshida, H. Tags: Original Articles Source Type: research
Lipoprotein lipase and atherosclerosis
Lipoprotein lipase has long been known to hydrolyse triglycerides from triglycerides-rich lipoproteins. More recently, it has been shown to promote the binding of lipoproteins to various lipoprotein receptors. Evidence is also presented regarding the possible atherogenic role of lipoprotein lipase. In theory, lipoprotein lipase deficiency should help to clarify this question. However, the rarity of this condition means that it has not been possible to conduct epidemiological studies. An alternative approach is to investigate the correlation of lipoprotein lipase with onset of cardiovascular disease in prospective studies i...
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Kobayashi, J., Mabuchi, H. Tags: Review Article Source Type: research
Biochemistry laboratories should routinely report non-HDL-cholesterol
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - October 19, 2015 Category: Biochemistry Authors: Preiss, D., Neely, D. Tags: Editorial Source Type: research
Evidence-based emergency care: diagnostic testing and clinical decision rules
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Barth, J. Tags: Book Reviews Source Type: research
Inborn errors of metabolism: from neonatal screening to metabolic pathways
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Stockdale, C. Tags: Book Reviews Source Type: research
High sensitivity cardiac troponin and the under-diagnosis of myocardial infarction in women: prospective cohort study
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Kaur, S. Tags: Journal Watch Source Type: research
Statistical correction of potassium in haemolysed samples
(Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Jones, G. R., Hawkins, R. Tags: Letters Source Type: research
Undetectable pregnancy-associated plasma protein-A in antenatal serum Down's syndrome screening: a case of assay interference
We present the case of an undetectable pregnancy-associated plasma protein-A concentration on the PerkinElmer AutoDELFIA system where immunoassay interference was suspected. Investigations performed, including dilution and recovery studies and antibody-blocking tube incubations, all yielded serum pregnancy-associated plasma protein-A concentrations of <25 mU/L. Pregnancy-associated plasma protein-A was also undetectable on two alternative pregnancy-associated plasma protein-A assays. An experimental manual Delfia procedure suggested the site of interference was between the secondary antibody and the pregnancy-associated...
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Williams, C., Hambridge, K., Petchey, M., Martin, J., Spencer, K. Tags: Case Reports Source Type: research
Fluorosis and periostitis deformans as complications of prolonged voriconazole treatment
We describe a case of development of painful periostitis deformans in a 39-year-old woman who was receiving long-term voriconazole treatment for Aspergillus infection as a complication of orthotopic liver transplant. Measurement of fluoride levels strongly supports fluorosis to be the mechanism of the voriconazole-induced periostitis deformans and supports the concept that such measurements might be of use in predicting this complication of long-term voriconazole treatment. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Rad, B., Saleem, M., Grant, S., Florkowski, C., Coates, P., Gordon, D., Rankin, W. Tags: Case Reports Source Type: research
Salivary cortisol and cortisone responses to tetracosactrin (synacthen)
Conclusions
Measurement of salivary cortisol and cortisone responses offers an alternative to those of serum cortisol during a synacthen test in the investigation of adrenal hypofunction. (Source: Annals of Clinical Biochemistry)
Source: Annals of Clinical Biochemistry - August 24, 2015 Category: Biochemistry Authors: Cornes, M. P., Ashby, H. L., Khalid, Y., Buch, H. N., Ford, C., Gama, R. Tags: Short Report Source Type: research
