A prospective observational study of the change in systemic ionised calcium following 4% citrate locking of venous haemodialysis catheters in intensive care patients
Traditionally heparin has been the anticoagulant of choice for venous dialysis catheter locking. There is systemic leakage of heparin catheter locking solutions at the time of injection. Alternative agents, such as citrate, are increasingly being used. We are not aware of any data in the critical care literature on the effect of citrate locking of venous dialysis catheters on systemic ionised calcium (iCa2+). To assess the effect of 4% citrate locking of venous dialysis catheters on systemic iCa2+ in intensive care patients we performed a prospective observational study of 50 paired samples in 26 intensive care patients re...
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
Optimised dosing of vancomycin in critically ill Indigenous Australian patients with severe sepsis
This study aimed to describe the pharmacokinetics (PK) of vancomycin in Australian Indigenous patients with severe sepsis, and advise an optimal dosing strategy. A population PK study was conducted in a remote Australian intensive care unit (ICU). Serial plasma samples were collected over one to two dosing intervals and assayed by validated chromatography. Concentration –time data collected were analysed using Pmetrics® software. The final population PK model was then used for Monte Carlo dosing simulations to determine optimal loading and intermittent maintenance doses. Fifteen Indigenous subjects were included for ana...
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
The incidence of hyperthermia during craniotomy
There is evidence that even mild hyperthermia may exacerbate brain injury. There seem reasonable grounds for considering patients undergoing craniotomy as at risk for brain injury. A retrospective observational study was undertaken to measure the incidence of mild hyperthermia in craniotomy cases in which the patient was initially normothermic. Auckland City Hospital ’s database of electronic anaesthetic records was searched for adult patients who were normothermic (≤37°C) prior to undergoing craniotomy procedures. For each case, demographic data, intraoperative naso- or oropharyngeal temperature measurements, and par...
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
The use of Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) for pre-oxygenation in neurosurgical patients: a randomised controlled trial
This study explored the use of high-flow nasal oxygen (HFNO) in both pre-oxygenation and apnoeic oxygenation in adults who were intubated following a non –rapid sequence induction. Fifty patients were randomised to receive pre-oxygenation via a standard facemask or the Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) device. After five minutes of pre-oxygenation, induction and muscle relaxant agents were given. While waiting f or complete paralysis, patients in the standard facemask group received bag–mask ventilation (BMV), whereas patients in the HFNO group received apnoeic oxygenation via the T...
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
Late, transient return of pulsatility: should we change donation after circulatory death protocols?
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
The origins of cardiopulmonary bypass
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - July 2, 2018 Category: Anesthesiology Source Type: research
Combined use of C-MAC ® videolaryngoscope and nasal videobronchoscope for critical airway rescue and intubation
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Transversus abdominis plane catheters versus rectus sheath catheters —it’s all in the placement
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Discrepancy between factors associated with long-term outcome in very old patients referred to the intensive care unit, and prevalence of treatment limitations
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Medical Emergency Team calls within 24 hours of surgery and strategy for reduction
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
In reply to Liu
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
The use of a frailty index to predict adverse postoperative outcomes of older surgical patients
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Addressing burnout in anaesthesia trainees —reply
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Addressing burnout in anaesthetic trainees
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
Burnout in anaesthesia trainees
(Source: Anaesthesia and Intensive Care)
Source: Anaesthesia and Intensive Care - May 2, 2018 Category: Anesthesiology Source Type: research
