AJP: Lung Cellular and Molecular Physiology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Potentiators exert distinct effects on human, murine, and Xenopus CFTR
VX-770 (Ivacaftor) has been approved for clinical usage in cystic fibrosis patients with several CFTR mutations. Yet the binding site(s) on CFTR for this compound and other small molecule potentiators are unknown. We hypothesize that insight into this question could be gained by comparing the effect of potentiators on CFTR channels from different origins, e.g., human, mouse, and Xenopus (frog). In the present study, we combined this comparative molecular pharmacology approach with that of computer-aided drug discovery to identify and characterize new potentiators of CFTR and to explore possible mechanism of action. Our res...
Source: AJP: Lung Cellular and Molecular Physiology - July 31, 2016 Category: Respiratory Medicine Authors: Cui, G., Khazanov, N., Stauffer, B. B., Infield, D. T., Imhoff, B. R., Senderowitz, H., McCarty, N. A. Tags: CALL FOR PAPERS Source Type: research

Alveolar epithelial disintegrity in pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease characterized by progressive decline in lung function, resulting in significant morbidity and mortality. Current concepts of the pathogenesis of IPF primarily center on dysregulated epithelial cell repair and altered epithelial-mesenchymal communication and extracellular matrix deposition following chronic exposure to cigarette smoke or environmental toxins. In recent years, increasing attention has been directed toward the role of the intercellular junctional complex in determining the specific properties of epithelia in pulmonary diseases. Additionally, recent...
Source: AJP: Lung Cellular and Molecular Physiology - July 31, 2016 Category: Respiratory Medicine Authors: Kulkarni, T., de Andrade, J., Zhou, Y., Luckhardt, T., Thannickal, V. J. Tags: CALL FOR PAPERS Source Type: research

Author response to letter to editor: Hyperinsulinemia adversely affects lung structure and function
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - July 11, 2016 Category: Respiratory Medicine Authors: Singh, S., Bodas, M., Bhatraju, N. K., Pattnaik, B., Gheware, A., Parameswaran, P. K., Thompson, M., Freeman, M., Mabalirajan, U., Gosens, R., Ghosh, B., Pabelick, C., Linneberg, A., Prakash, Y. S., Agrawal, A. Tags: LETTER TO THE EDITOR Source Type: research

Response to paper by Singh et al. "Hyperinsulinemia adversely affects lung structure and function"
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - July 11, 2016 Category: Respiratory Medicine Authors: Wolff, R. K., Brain, J. D., Patton, J. S., Liggitt, D. Tags: LETTER TO THE EDITOR Source Type: research

The bronchodilatory capacity of imiquimod: the existence of two mechanisms
(Source: AJP: Lung Cellular and Molecular Physiology)
Source: AJP: Lung Cellular and Molecular Physiology - July 11, 2016 Category: Respiratory Medicine Authors: Larsson, O. J., Manson, M. L., Starkhammar, M., Fuchs, B., Adner, M., Kumlien Georen, S., Cardell, L.-O. Tags: LETTER TO THE EDITOR Source Type: research