Cellular models for beta ‐cell function and diabetes gene therapy
Abstract
Diabetes is characterized by the destruction and/or relative dysfunction of insulin‐secreting beta‐cells in the pancreatic islets of Langerhans. Consequently, considerable effort has been made to understand the physiological processes governing insulin production and secretion in these cells and to elucidate the mechanisms involved in their deterioration in the pathogenesis of diabetes. To date, considerable research has exploited clonal beta‐cell lines derived from rodent insulinomas. Such cell lines have proven to be a great asset in diabetes research, in vitro drug testing, and studies of beta‐cell phy...
Source: Acta Physiologica - January 17, 2018 Category: Physiology Authors: A. D. Green, S. Vasu, P. R. Flatt Tags: REVIEW Source Type: research
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Acta Physiologica,Volume 222, Issue 3, March 2018. (Source: Acta Physiologica)
Source: Acta Physiologica - January 16, 2018 Category: Physiology Source Type: research
Uniaxial strain of cultured mouse and rat cardiomyocyte strands slows conduction more when its axis is parallel to impulse propagation than when it is perpendicular
Acta Physiologica,Volume 223, Issue 1, May 2018. (Source: Acta Physiologica)
Source: Acta Physiologica - January 15, 2018 Category: Physiology Authors: A. Buccarello
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M. Azzarito
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F. Michoud
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S. P. Lacour
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J. P. Kucera Source Type: research
Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid ‐dependent mechanism
Acta Physiologica,Volume 223, Issue 1, May 2018. (Source: Acta Physiologica)
Source: Acta Physiologica - January 15, 2018 Category: Physiology Authors: L. Olejn íková
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L. Polidarová
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A. Sumová Source Type: research
Stress affects expression of the clock gene Bmal1 in the suprachiasmatic nucleus of neonatal rats via glucocorticoid ‐dependent mechanism
Acta Physiologica, EarlyView. (Source: Acta Physiologica)
Source: Acta Physiologica - January 15, 2018 Category: Physiology Source Type: research
