Primary Ciliary Dyskinesia: Update and Review
A very thorough and up-to-date review of primary ciliary dyskinesia, which is a heterogenous group of related disorders. Most of us learned about the diagnostic ultrastructural abnormalities described in these patients, but one point of interest for me is that... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - November 25, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Bronchiectasis Lung Disease Primary Ciliary Dyskinesia Source Type: blogs
Chronic Bronchitis and Chronic Obstructive Lung Disease Review
Although commonly thought of synonymous, or, at least, forming a spectrum, chronic bronchitis is distinct from COPD. This review focuses on the pathophysiology of chronic bronchitis and goblet cell hyperplasia and the association between small airways disease and worse outcomes... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - November 18, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Chronic Obstructive Lung Disease Lung Pathology Source Type: blogs
RBC immunization in sickle cell disease--revisited
Stella Chou and co-authors published a very interesting and somewhat disquieting paper in the August 8, 2013 edition of Blood (abstract), "High prevalence of RBC immunization in sickle cell disease despite transfusion from Rh-matched minority donors." This paper is an... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - November 16, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Blood Banking RBC Transfusion Transfusion in Sickle Cell Disease Source Type: blogs
Does anemia impact hospital readmission rates after CABG surgery?
Nadine Shehata and colleagues studied this question in a recently published article (abstract) in the August 2013 issue of Transfusion. This is a single-institution study of 2,102 patients who underwent CABG surgery at the University of Ottawa Hospital. 224 of... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - November 9, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Blood Banking Blood Management Blood Utilization Source Type: blogs
AHA White Paper on Utilization of Medical Resources
The AHA has published a free white paper, "Appropriate Use of Medical Resources," that can be accessed and downloaded as a pdf file from the link. Of interest to pathologists, and particularly to laboratory medical directors and transfusion medicine physicians,... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - November 7, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Blood Management Blood Utilization Source Type: blogs
New government regs threaten medical testing labs - The Hill's Congress Blog
Interesting (and frustrating) post from The Hill. Why are hospital and small independent labs being punished because of the actions of large commercial labs abusing the Medicare system? We are the ones trying to honestly provide a service to all... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - October 1, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Source Type: blogs
Role of Bone Marrow-Derived HPCs in Pulmonary Fibrosis
Interesting article from AJRCCM just published online that adds to accumulating data implicating circulating bone marrow-derived hematopoietic progenitor cells in the development of lung fibrosis. Abstract below. Rationale: Bone marrow (BM)-derived cells have been implicated in pulmonary fibrosis, however, their... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - September 9, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Interstitial Lung Disease Source Type: blogs
ETS2 mediates tumor suppressor function and MET inhibition in lung adenocarcinoma
There was a very intriguing paper published online by Clinical Cancer Research on May 9 last week that should be of interest for those involved in lung cancer research. The authors are Mohamed Kabbout, Melinda Garcia, Junya Fujimoto, et al.... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - May 13, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Biomarkers in Lung Cancer Lung adenocarcinoma Molecular Pathology Non small cell lung cancer Source Type: blogs
NKX2-1/TTF-1 drives pulmonary-specific differentiation in lung adenocarcinoma
Snyder et al. recently published an intriguing report in Molecular Cell (21 March 2013) (featured free article) in which they convincingly demonstrate how tumors in which Nkx2-1 was deleted show striking different morphology from those in which Nkx2-1 is expressed.... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - May 8, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Lung adenocarcinoma Lung Biology Lung Cancer Source Type: blogs
CAP releases guidelines for validating whole slide imaging
The College of American Pathologists has released guidelines for validating whole slide imaging. While stating the lack of FDA approval for using WSI for primary diagnosis, the College is acknowledging the very likely adoption of WSI for primary diagnosis in... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - May 2, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Digital Pathology Source Type: blogs
BRAF mutations in colorectal cancer: mini-review
There has been a recent flurry of papers and reports from ASCO-GI 2013 pushing more molecular testing in colorectal cancer (CRC) and its clinical significance with regard to prognostic and predictive factors, especially with MMR/MSI. One area that caught my... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - April 26, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Colorectal Cancer Source Type: blogs
Atomic force microscopy! EMT and idiopathic pulmonary fibrosis
Here is a very intesting article I recently found with some very cool technology: Abstract: Epithelial-mesenchymal transition (EMT) is closely implicated in the pathogenesis of idiopathic pulmonary fibrosis. Associated with this phenotypic transition is the acquisition of an elongated cell... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - March 23, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Epithelial-to-Mesenchymal Transition Interstitial Lung Disease Source Type: blogs
Imaging tumors in the future
Baohong Yuan and Joshua Rychak have written an interesting review in the February 2013 American Journal of Pathology that outlines emerging techniques based on ultrasound to obtain functional and molecular imaging of tumors. Apart from being fascinating reading, this article... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - January 29, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Future of Pathology Image Analysis Source Type: blogs
Pathologists to Blame for Hindering Acquisition of Cancer Tissue for Genomic Testing?
Medscape recently posted an article that discusses the need for standards for acquiring, preserving and storing cancer tissue, citing a recent Viewpoint article in JAMA by Drs. Laura Goetz, Kelly Bethel, and Eric Topol. If you have the chance, I... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - January 7, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Molecular Pathology Source Type: blogs
New Device to Check Margins in Breast Cancer Surgery
Just a follow-up to yesterday's post regarding surgical margins in breast cancer. Will this device obviate inking the specimen or the debate about how much margin is "enough"? Quoted from Medscape article by Zosia Chustecka: The new device, MarginProbe (Dune... (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - January 5, 2013 Category: Pathologists Authors: Mark D. Pool, M.D. Tags: Breast cancer Source Type: blogs
