Effectiveness of crossmatched or HLA-platelets vs. random platelets for refractory patients
Rioux-Mass é et al from University of Minnesota Medical Center report in the December 2014 issue of Transfusion (abstract) a retrospective study of 32 patients who had laboratory confirmation of immune-mediated PLT refractoriness, and received platelet transfusion with crossmatched or HLA-matched PLTs. Immune-mediated refractoriness was called"positive" when a PLT crossmatch was incompatible with at least 1 unit or an HLA antibody screen detected HLA Class I antibody against any number of antigens in a single-well test system. The HLA antibody avoidance technique was not used by the blood...
Source: The Daily Sign-Out - February 12, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Platelet Transfusion Source Type: blogs
Effectiveness of crossmatched or HLA-platelets vs. random platelets for refractory patients
Rioux-Massé et al from University of Minnesota Medical Center report in the December 2014 issue of Transfusion (abstract) a retrospective study of 32 patients who had laboratory confirmation of immune-mediated PLT refractoriness, and received platelet transfusion with crossmatched or HLA-matched PLTs.
Immune-mediated refractoriness was called "positive" when a PLT crossmatch was incompatible with at least 1 unit or an HLA antibody screen detected HLA Class I antibody against any number of antigens in a single-well test system. The HLA antibody avoidance technique was not used by the bl...
Source: The Daily Sign-Out - February 12, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Platelet Transfusion Source Type: blogs
DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis
In case you may have missed this one, Ivana Yang and colleagues from the University of Colorado have published a fascinatingarticle in the December 1, 2014 issue of American Journal of Respiratory and Critical Care Medicine,"Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis," that explores possible epigenetic mechanisms through DNA methylation that may be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF).Many of these studies are being done in various cancers, but this one suggests one or more programs that unfold with IPF. (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - February 11, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Source Type: blogs
DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis
In case you may have missed this one, Ivana Yang and colleagues from the University of Colorado have published a fascinating article in the December 1, 2014 issue of American Journal of Respiratory and Critical Care Medicine, "Relationship of DNA Methylation and Gene Expression in Idiopathic Pulmonary Fibrosis," that explores possible epigenetic mechanisms through DNA methylation that may be involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF).
Many of these studies are being done in various cancers, but this one suggests one or more programs that unfold with IPF.
(Source: The Daily Sign-Out)
Source: The Daily Sign-Out - February 11, 2015 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Tags: Idiopathic Pulmonary Fibrosis Interstitial Lung Disease Source Type: blogs
Lung Cancer Screening--from the International Association for the Study of Lung Cancer
November is Lung Cancer Awarenesss Month and IASLC has issued some valuable talking points that could be useful for lung cancer screening with patients, colleagues, and the general public. Lung Cancer is the #1 cancer killer in the world, killing more people than breast, colorectal and prostate cancers combined. Recent advances in Lung Cancer Screening and Early Detection are providing hope for patients and their families that has never before existed in the field of lung cancer. The potential for saving lives through lung cancer low-dose computed tomography (LDCT) screening will dramatically change the d...
Source: The Daily Sign-Out - November 13, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Lung Cancer Screening--from the International Association for the Study of Lung Cancer
November is Lung Cancer Awarenesss Month and IASLC has issued some valuable talking points that could be useful for lung cancer screening with patients, colleagues, and the general public.
Lung Cancer is the #1 cancer killer in the world, killing more people than breast, colorectal and prostate cancers combined.
Recent advances in Lung Cancer Screening and Early Detection are providing hope for patients and their families that has never before existed in the field of lung cancer.
The potential for saving lives through lung cancer low-dose computed tomography (LDCT) screening will dramatically change ...
Source: The Daily Sign-Out - November 13, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
https://clincancerres.aacrjournals.org/content/20/20/5322.abstract?etoc
Sent from my iPad (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - October 15, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
//clincancerres.aacrjournals.org/content/20/20/5322.abstract?etoc
Sent from my iPad (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - October 15, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Mismatch Repair Status and BRAF Mutation Status in Metastatic Colorectal Cancer Patients: A Pooled Analysis of the CAIRO, CAIRO2, COIN, and FOCUS Studies
http://clincancerres.aacrjournals.org/content/20/20/5322.abstract?etoc
Sent from my iPad (Source: The Daily Sign-Out)
Source: The Daily Sign-Out - October 15, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Novel cutaneous and pulmonary syndrome associated with mutations in STING
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with numerous clinical pictures and photomicrographs in the supplementary appendix that nicely illustrate the pathologic changes. This work sheds light on an important inflammatory pathway through the description of this"experiment of nature."Liu Y, Jesus AA, Marrero B, et al. Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medicine ...
Source: The Daily Sign-Out - August 6, 2014 Category: Cancer & Oncology Authors: Mark D. Pool, M.D. Source Type: blogs
Novel cutaneous and pulmonary syndrome associated with mutations in STING
Fascinating article describing a vasculopathic cutaneous and pulmonary syndrome associated with autosomal dominant mutations in TMEM173, the gene encoding stimulator of interferon genes (STING). An incredible body of work presented with numerous clinical pictures and photomicrographs in the supplementary appendix that nicely illustrate the pathologic changes. This work sheds light on an important inflammatory pathway through the description of this "experiment of nature."
Liu Y, Jesus AA, Marrero B, et al. Activated STING in a Vascular and Pulmonary Syndrome. New England Journal of Medic...
Source: The Daily Sign-Out - August 6, 2014 Category: Pathologists Authors: Mark D. Pool, M.D. Source Type: blogs
