JAMA: 2007-06-06, Vol. 297, No. 21, Author in the Room Audio Interview
Interview with Bernard Cole, PhD, and Robert S. Sandler, MD, authors of Folic Acid for Prevention of Colorectal Adenomas. Summary Points: 1. Folic acid supplementation is not useful for preventing colorectal adenomas. 2. Folic acid supplementation may be harmful through increasing colorectal adenomas. 3. Practitioners and patients should wait for strong evidence before initiating therapies given the potential for waste and unintended adverse consequences. (Source: JAMA Author in the Room)
Source: JAMA Author in the Room - July 24, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2007-05-09, Vol. 297, No. 18, Author in the Room Audio Interview
Interview with Steven R. Steinhubl, MD, author of Aspirin Dose for the Prevention of Cardiovascular Disease. Summary Points: 1. While aspirin is generally a safe drug and extremely effective, with more than 50 million US adults taking it every day for cardiovascular disease prevention, even a very small incidence of adverse effects can have major implications. Consistent with this, one study found that the most common medication leading to an adverse event requiring hospitalization was aspirin for cardiovascular disease prevention. 2. In terms of preventing heart attacks, strokes, or cardiovascular deaths, no clinical tria...
Source: JAMA Author in the Room - July 13, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2007-04-04, Vol. 297, No. 13, Author in the Room Audio Interview
Interview with Jan L. Brandes, MD, author of Sumatriptan-Naproxen for Acute Treatment of Migraine. Summary Points: 1. Evidence from two replicate randomized, double-blind, placebo-controlled trials showed sumatriptan-naproxen as a fixed dose combination was superior in treating an attack of migraine when compared with sumatriptan alone, naproxen alone, or placebo. 2. Most importantly, given that migraine attacks in adults are 4 to 72 hours in duration, the fixed-dose combination of sumatriptan-naproxen was significantly more effective than sumatriptan monotherapy or naproxen monotherapy in providing a 24-hour sustained pai...
Source: JAMA Author in the Room - July 13, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2007-03-07, Vol. 297, No. 9, Author in the Room Audio Interview
Interview with Peter B. Bach, MD, author of Computed Tomography Screening and Lung Cancer Outcomes. Summary Points: 1. Screening and other prevention approaches involve subjecting very large numbers of people to an intervention, with the expectation that a few will benefit, but most will not (as they would have never developed the condition anyway). 2. In general, screening for diseases such as cancer will uncover some reservoir of abnormalities that appear to be precursors to clinical disease but are not yet causing disease. 3. We really have no evidence to support screening for lung cancer right now with any technology....
Source: JAMA Author in the Room - July 12, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2007-02-14, Vol. 297, No. 6, Author in the Room Audio Interview
Interview with Paul M. Ridker, MD, MPH, author of Development and Validation of Improved Algorithms for the Assessment of Global Cardiovascular Risk in Women: The Reynolds Risk Score. Summary Points: 1. Half of all heart attacks and strokes occur among those with normal cholesterol levels and 15-20% occur among those with no major risk factors at all. 2. The major breakthroughs in understanding cardiovascular disease over the past decade include insights about inflammation and genetics. Each of these can easily be ascertained with either a simple blood test (hsCRP for inflammation) or a simple question about parental histo...
Source: JAMA Author in the Room - April 13, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2007-01-03, Vol. 297, No. 1, Author in the Room Audio Interview
Interview with David Ganz, MD, MPH, author of The Rational Clinical Exam: Will My Patient Fall? Summary Points: 1. Screening for falls is as simple as asking the patient if she's fallen in the past year. For patients who have not fallen, ask about gait or balance problems (e.g. "Do you have a walking or balance problem?"). 2. Most older patients who have a history of falls in the past year, or a gait/balance problem, have at least a 50% chance of falling in the coming year. You may want to do a more thorough evaluation on these patients. 3. To make screening easy for new patients, add into your pre-visit questionnaire ques...
Source: JAMA Author in the Room - February 22, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-12-27, Vol. 296, No. 24, Author in the Room Audio Interview
Interview with Dennis Black, PhD, author of The Effects of Continuing or Stopping Alendronate after Five Years of Treatment: Results from the Fracture Intervention Trial Long-term Extension. Summary Points: 1. The long-term use of alendronate for up to 10 years is safe. 2. Those who discontinued treatment at 5 years lost bone mass compared with those who continued but the bone loss was only moderate. Rates of fracture were similar among those who continued vs those who discontinued except for clinical vertebral fractures which, although relatively uncommon, were higher in those who discontinued treatment. 3. Results sugges...
Source: JAMA Author in the Room - January 24, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-11-15, Vol. 296, No. 19, Author in the Room Audio Interview
Interview with Louise Walter, MD, author of PSA Screening Among Elderly Men With Limited Life Expectancies. Summary Points: 1. Most cancer screening guidelines do not recommend screening elderly persons in poor health who have limited life expectancies because the harms of screening (which occur immediately) outweigh the potential benefits (which occur many years in the future). 2. PSA screening rates among elderly men with limited life expectancies should be much lower than current practice to avoid harming these men with unnecessary tests and procedures. 3. Guidelines should be more explicit about how life expectancy is ...
Source: JAMA Author in the Room - January 24, 2007 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-10-18, Vol. 296, No. 15, Author in the Room Audio Interview
Interview with Dariush Mozaffarian, MD, DrPH, author of Fish Intake, Contaminants, and Human Health, published in the October 18 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. For the general population, the health benefits of fish intake far outweigh the risks. 2. Women of childbearing age, nursing mothers and young children should eat up to two servings of fish per week as the benefits of fish intake still outweigh the risks. 3. Given the magnitude of the benefits, physicians should regularly give dietary advice to patients for cardiovascular disease prevention. (Source: JAMA Author in the Room)
Source: JAMA Author in the Room - November 16, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-09-13, Vol. 296, No. 10, Author in the Room Audio Interview
Interview with David Mark Spiro, MD, MPH, author of Wait-and-See Prescription for the Treatment of Acute Otitis, published in the September 13 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Wait-and-See Prescription (WASP) is a viable approach to managing children with acute otitis media. Compared with the standard prescription group, the WASP group filled the antimicrobial prescription much less frequently and had equivalent clinical outcomes. 2. Within the WASP group, fever and ear pain were associated with filling the prescription demonstrating that parents are able to make appropriat...
Source: JAMA Author in the Room - October 18, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-08-02, Vol. 296, No. 5, Author in the Room Audio Interview
Interview with Harriet L. MacMillan, MD, MSc, FRCP(C), author of Approaches to Screening for Intimate Partner Violence in Health Care Settings: A Randomized Trial, published in the August 8 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Even though we have long assumed that clinicians should ask patients directly about intimate partner violence, this study shows that self-complete methods for soliciting such information are preferred by women, and may be more efficient. 2. The prevalence rate for intimate partner violence differs by setting and population and varies significantly from ap...
Source: JAMA Author in the Room - September 26, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-07-05, Vol. 296, No. 1, Author in the Room Audio Interview
Interview with David Gonzales, PhD, and Stephen Rennard, MD, authors of Helping Patients Stop Smoking: Varenicline vs Bupropion, published in the July 5 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. There is a new and novel pharmaceutical approach to treating nicotine addiction that helps smokers quit by specifically targeting nicotine receptors. 2. Efficacy for varenicline was three to four times that of placebo and twice that of bupropion at the end of 12 weeks of treatment, but abstinence rates in all groups declined after drug treatment ended. 3. The launch of a new smoking cessatio...
Source: JAMA Author in the Room - September 22, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-06-21, Vol. 295, No. 23, Author in the Room Audio Interview
Interview with Victor G. Vogel, MD, MHS, author of Effects of Tamoxifen vs Raloxifene on the Risk of Developing Invasive Breast Cancer and Other Disease Outcomes , published in the June 21 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Raloxifene is as effective in reducing the risk of invasive breast cancer in postmenopausal women who are at increased risk of the disease. 2. The safety profile of raloxifene is more favorable than tamoxifen with fewer hysterectomies, uterine malignancies, serious thrombotic events, and cataracts. 3. Both physicians and patients are familiar with raloxife...
Source: JAMA Author in the Room - July 19, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-03-08, Vol. 295, No. 18, Author in the Room Audio Interview
Interview with Christopher M. Callahan, MD, author of Effectiveness of Collaborative Care for Older Adults With Alzheimer Disease in Primary Care: A Randomized Controlled Trial, published in the May 10 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Primary care practices have standard protocols to offer a patient with Alzheimer Disease and their caregivers. 2. The quality of care of many geriatric syndromes, including Alzheimer Disease, can be improved by implementing a collaborative care model. 3. Similarly to many geriatric syndromes, medication may be useful, but it is not enough. Med...
Source: JAMA Author in the Room - July 19, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
JAMA: 2006-03-08, Vol. 295, No. 10, Author in the Room Audio Interview
Interview with William Taylor, MD, author of A 71-Year-Old Woman Contemplating a Screening Colonoscopy, published in the March 8 issue of JAMA, the Journal of the American Medical Association. Summary Points: 1. Embedded in experts’ recommendations for colorectal cancer screening are nearly impossible demands on primary care clinicians to discuss the pros and cons of various modalities for screening with each patient and to assess risk even to the detail of learning the pathology of the biopsy of relatives’ colonoscopies (e.g., adenomatous vs. hyperplastic polyps). 2. The complex set of components involved in the decis...
Source: JAMA Author in the Room - May 31, 2006 Category: Journals (General) Authors: The JAMA Network Source Type: podcasts
