FGFR4 is a Prognostic Marker and Therapeutic Target for Ovarian Cancer
Researchers have identified FGFR4 as a prognostic marker and therapeutic target for ovarian cancer. In the journal Clinical Cancer Research, a group of researchers, including current and past OCRF grantees Anil Sood and Gabriel Lopez-Berestein, evaluated the prognostic value of fibroblast growth factor receptor 4 (FGFR4) protein expression in patients with advanced-stage, high-grade serous ovarian cancer. They found that FGFR4 is a prognostic marker for the disease. Furthermore, silencing FGFR4 significantly decreases ovarian tumor growth. These findings suggest that targeting those ovarian cancer cells with high l...
Source: OCRF News - January 25, 2013 Category: Cancer & Oncology Source Type: news
Extended Breastfeeding Reduces the Risk of Ovarian Cancer
Extended breastfeeding reduced the risk of ovarian cancer.In a study published in the American Journal of Clinical Nutrition, researchers from Curtin University in Australia found that extended breastfeeding significantly reduces the risk of ovarian cancer in women. The study examined 493 Chinese women who had been diagnosed with ovarian cancer. The study found that women who breastfed for more than 13 months were 63 percent less likely to develop an ovarian tumor than women who breastfed for less than seven months. In addition, the longer women breastfed, the greater the reduced risk. Women who had three children an...
Source: OCRF News - January 23, 2013 Category: Cancer & Oncology Source Type: news
Extended Breastfeeding Reduceds the Risk of Ovarian Cancer
Extended breastfeeding reduced the risk of ovarian cancer.In a study published in the American Journal of Clinical Nutrition, researchers from Curtin University in Australia found that extended breastfeeding significantly reduces the risk of ovarian cancer in women. The study examined 493 Chinese women who had been diagnosed with ovarian cancer. The study found that women who breastfed for more than 13 months were 63 percent less likely to develop an ovarian tumor than women who breastfed for less than seven months. In addition, the longer women breastfed, the greater the reduced risk. Women who had three children an...
Source: OCRF News - January 23, 2013 Category: Cancer & Oncology Source Type: news
Examining Change in CA-125 Over Time to Identify Ovarian Cancer Earlier
A new approach to monitoring CA-125, using an algorithm that looks at its change over time, is more effective at identifying ovarian cancer earlier than using a single-threshold number. In a study published in the Journal of Clinical Oncology, researchers report that a new approach to monitoring CA-125, using an algorithm that looks at its change over time, is more effective at identifying ovarian cancer earlier than using a single-threshold number. The researchers also suggest that this approach may be useful in screening for other cancers in which biomarkers are available. Read the abstract here. (Source: OCRF News)
Source: OCRF News - January 22, 2013 Category: Cancer & Oncology Source Type: news
Meet OCRF's 2013 Research Grant Recipients
OCRF has awarded nearly $6 million in new research grants to sixteen investigators from top research institutions across the country. OCRF has awarded nearly $6 million in grants for ovarian cancer research this year. After receiving over 170 applications – the highest number in its history, for the second year in a row – OCRF and its prestigious Scientific Advisory Committee endeavored first and foremost to fund the best science. The Committee evaluated each proposal through intensive peer review, and selected a sound portfolio of 2013 grants that represent the present and future of ovarian cancer research."We receiv...
Source: OCRF News - January 10, 2013 Category: Cancer & Oncology Source Type: news
DNA from Pap Smears Could Help Detect Endometrial and Ovarian Cancer
In an article published today in Science Translational Medicine, researchers suggest that analyzing DNA from Pap smears could help detect endometrial and ovarian cancer. Analyzing DNA from Pap smears could help detect endometrial and ovarian cancer, a new study published Jan. 9, 2013 in Science Translational Medicine reports. OCRF Scientific Advisory Committee member (and former grantee) Doug Levine, MD, was among the authors of the article, which was highlighted on the cover of the journal.The routine Pap smear, which allows doctors to detect abnormal cells in a woman's cervix, was recently updated to scree...
Source: OCRF News - January 9, 2013 Category: Cancer & Oncology Source Type: news
New Research on Screening for Familial Ovarian Cancer
New research suggests "a ray of hope and a light to steer by" when searching for how to screen for familial ovarian cancer. In the most recent edition of the Journal of Clinical Oncology, researchers in the UK published preliminary results from the United Kingdom Familial Ovarian Cancer Screen Study, a large trial testing the hypothesis that ovarian cancer screening may benefit women at familial risk. Results showed that annual screening did lead to diagnosis at an earlier stage, and (while not statistically significant) there were also trends toward improvement in optimal surgical cytoreduction and overall surviv...
Source: OCRF News - January 3, 2013 Category: Cancer & Oncology Source Type: news
No Long-Term Survival Benefit for BRCA Mutation Carriers
Short-term survival advantage of BRCA mutation carriers does not lead to a long-term survival advantage. Previous studies have suggested that BRCA mutation carriers with ovarian cancer have better survival rates than women who are not carriers. Researchers in Canada and the US sought to investigate long-term survival (10 years post diagnosis) in BRCA mutation carriers. Their results show that "for women with invasive ovarian cancer, the short-term survival advantage of carrying a BRCA1 or BRCA2 mutation does not lead to a long-term survival benefit." The research was published in the Journal of the National Cancer...
Source: OCRF News - January 1, 2013 Category: Cancer & Oncology Source Type: news
