[Cholesterol Sensing] Lysosomal cholesterol activates mTORC1
The mTORC1 kinase is a master nutrient sensor that governs cellular metabolism. When dysregulated, this kinase drives several human diseases, including cancer and diabetes. Recent work – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: L. Bryan Ray Tags: Cholesterol Sensing Source Type: research
[Cancer Therapy] Chromatin state dictates drug response
Drugs inhibiting the phosphoinositide-(3)-kinase (PI3K) signaling pathway are effective in a subset of breast cancer patients. Tumors become resistant to these drugs, however, and this – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Paula A. Kiberstis Tags: Cancer Therapy Source Type: research
[Perovskite Physics] How perovskites have the edge
Two-dimensional Ruddlesden-Popper perovskites form quantum wells by sandwiching inorganic-organic perovskite layers used in photovoltaic devices between organic layers. Blancon et – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Phil Szuromi Tags: Perovskite Physics Source Type: research
[Active Matter] Go with the changing flow
The transport of ordinary fluids tends to be driven by pressure differentials, whereas for active or biological matter, transport may be isotropic or governed by the presence of specific – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Marc S. Lavine Tags: Active Matter Source Type: research
[DNA Nanotechnology] Protein-folded DNA nanostructures
A wide variety of DNA nanostructures have been assembled by folding long DNA single strands with short DNA staples. However, such structures typically need annealing at elevated temperatures – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Phil Szuromi Tags: DNA Nanotechnology Source Type: research
[Ion Channels] Added complexity in an asymmetric receptor
N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric ion channels that initiate chemical and electrical signals in postsynaptic cells. They play key roles in brain development – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Valda Vinson Tags: Ion Channels Source Type: research
[Neuroscience] Dendrites are more active than expected
Dendrites occupy more than 90% of neuronal tissue. However, it has not been possible to measure distal dendritic membrane potential and spiking in vivo over a long period of time. Moore – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Peter Stern Tags: Neuroscience Source Type: research
[Volcanology] Making magma chambers from mush
Shallow magma chambers either erupt as volcanoes or solidify as intrusive magma bodies. These magma bodies are traditionally considered to be long-lived and dominated by melt. Cashman – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Brent Grocholski Tags: Volcanology Source Type: research
[Cancer Etiology] Cancer and the unavoidable R factor
Most textbooks attribute cancer-causing mutations to two major sources: inherited and environmental factors. A recent study highlighted the prominent role in cancer of replicative (R) – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Paula A. Kiberstis Tags: Cancer Etiology Source Type: research
[Neuroscience] Why pain and stress lead to depression
Chronic stress or pain is associated with the development of depression. Descalzi et al. examined gene expression changes in the brain in mouse models of nerve injury–or c – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Leslie K. Ferrarelli Tags: Neuroscience Source Type: research
[Immunological Memory] Helping T cells feel at home in the liver
Liver-resident T cells defend against infections such as malaria and hepatitis B virus. McNamara et al. found that liverresident CD8+ T cells up-regulate LFA-1 and – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Angela Colmone Tags: Immunological Memory Source Type: research
[Dengue Virus] Estimating transmission chains for dengue
Dengue virus (DENV) causes a large number of asymptomatic infections, so surveillance captures only a fraction of cases. Salje et al. developed a method for identifying the – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Caroline Ash Tags: Dengue Virus Source Type: research
[Psychology] Using “you” to generalize from me to others
Sometimes “you” is used when addressing another person, but in many situations, “you” is used to indicate anyone or everyone—the generic “you.” Orvell et al. studied the u – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Gilbert Chin Tags: Psychology Source Type: research
[Catalysis] Metal-oxide synergy
The hydrogenation of carbon dioxide is a key step in the industrial production of methanol. Catalysts made from copper (Cu) and zinc oxide (ZnO) on alumina supports are often used. – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Phil Szuromi Tags: Catalysis Source Type: research
[Metallurgy] Nanograined metals avoid going soft
The Hall-Petch relationship links a metal's increasing hardness with decreasing grain size, but it breaks down when grains become very small. This is unfortunate because nanograined – [Read More] (Source: This Week in Science)
Source: This Week in Science - March 23, 2017 Category: Science Authors: Brent Grocholski Tags: Metallurgy Source Type: research
