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Levothyroxine treatment of mild subclinical hypothyroidism: a review of potential risks and benefits
Subclinical hypothyroidism (SCH) is defined as elevated thyroid stimulating hormone (TSH) with normal levels of free triiodothyronine (FT3) and free thyroxine (FT4). SCH is further classified into a milder condition with TSH levels between 4.0 and 10.0 milli-international units (mIU)/l (mild-SCH) and a severe form with TSH >10.0 mIU/l (severe-SCH). SCH is a common problem (prevalence is greater in women than men), which increases further with increasing age and TSH levels. Even though the risk of progression to overt hypothyroidism is higher in patients with severe-SCH, the risk is also significant in patients having mi...
Source: Therapeutic Advances in Endocrinology and Metabolism - February 1, 2016 Category: Endocrinology Authors: Javed, Z., Sathyapalan, T. Tags: Reviews Source Type: research

An investigation of the associations among sleep duration and quality, body mass index and insulin resistance in newly diagnosed type 2 diabetes mellitus patients
Conclusions: Sleep quality, not sleep duration, plays an important role in insulin resistance in newly diagnosed type 2 diabetes mellitus patients. BMI may mediate the relationship between indicators of sleep quality and insulin resistance. There is a need to examine the impact of improving sleep quality on obesity and insulin resistance in patients with type 2 diabetes mellitus. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - February 1, 2016 Category: Endocrinology Authors: Arora, T., Chen, M. Z., Omar, O. M., Cooper, A. R., Andrews, R. C., Taheri, S. Tags: Original Research Source Type: research

The obesity of bone
During the last decades, obesity and osteoporosis have become important global health problems, and the belief that obesity is protective against osteoporosis has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems. Moreo...
Source: Therapeutic Advances in Endocrinology and Metabolism - November 15, 2015 Category: Endocrinology Authors: Greco, E. A., Lenzi, A., Migliaccio, S. Tags: Reviews Source Type: research

Pregnancy in acromegaly
With advances in surgical and medical treatment and the availability of assisted reproductive techniques, pregnancy in women with acromegaly is more frequently encountered. Diagnosis of acromegaly during pregnancy is difficult because of changes in growth hormone and insulin like growth factor-1 (IGF-1) axis secondary to placental production of growth hormone. The difficulty is compounded by the inability of routine hormone assays to detect placental growth hormone. In the majority of patients with acromegaly, pregnancy does not have an adverse effect on mother or fetus and pituitary mass does not increase in size. The lev...
Source: Therapeutic Advances in Endocrinology and Metabolism - November 15, 2015 Category: Endocrinology Authors: Laway, B. A. Tags: Reviews Source Type: research

Comparison of conventional risk factors in middle-aged versus elderly diabetic and nondiabetic patients with myocardial infarction: prediction with decision-analytic model
Conclusions: The CART model is capable of symbolizing interpretable clinical data for confirming and better prediction of MI occurrence in clinic or in hospital. Therefore, predictor variables in pattern could affect the outcome based on age group variable. Hyperglycemia, hypertension, hyperlipidemia and hyperuricemia were serious predictors for occurrence of MI in diabetics. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - November 15, 2015 Category: Endocrinology Authors: Mahmoodi, M. R., Baneshi, M. R., Rastegari, A. Tags: Original Research Source Type: research

Vitamin D as a risk factor for premature atherosclerosis in patients with type 2 diabetes
Conclusions: Decreased vitamin D levels in patients with diabetes lead to increased CIMT. The absence of a statistically significance difference in lipid profile between increased and normal CIMT groups raises the possibility of underlying causes for atherosclerosis in patients with diabetes other than dyslipidemia. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - November 15, 2015 Category: Endocrinology Authors: Hamdy Al-Said, N., Abd El Ghaffar Mohamed, N., Salam, R. F., Fawzy, M. W. Tags: Original Research Source Type: research

Effects on lipid profile of supplementation with vitamin D in type 2 diabetic patients with vitamin D deficiency
Conclusions: Correction of vitamin D deficiency in type 2 diabetic patients decreases total cholesterol. Our results do not rule out reductions in LDL cholesterol, non-HDL cholesterol and triglycerides. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - November 15, 2015 Category: Endocrinology Authors: Ramiro-Lozano, J. M., Calvo-Romero, J. M. Tags: Original Research Source Type: research

Effect of balance training with Biodex Stability System on balance in diabetic neuropathy
Conclusion: According to our results, balance training would improve postural stability and balance in elderly patients with DN. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Eftekhar-Sadat, B., Azizi, R., Aliasgharzadeh, A., Toopchizadeh, V., Ghojazadeh, M. Tags: Original Research Source Type: research

Effect of Ramadan fasting in Saudi Arabia on serum bone profile and immunoglobulins
Conclusions: Changes in dietary practices during Ramadan modulated PTH secretion to a pattern which might be beneficial to bone health. Combined effects of fasting and disturbed sleep led to a noted decrease in IgG level. Therefore, a possible beneficial effect of fasting on bone turnover is combined with decreased immune response. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Bahijri, S. M., Ajabnoor, G. M., Borai, A., Al-Aama, J. Y., Chrousos, G. P. Tags: Original Research Source Type: research

Exercise augments the nocturnal prolactin rise in exercise-trained men
Conclusion: Findings clearly demonstrated that nocturnal prolactin responses are augmented in exercise-trained men on days when they perform exercise. The mechanisms inducing this adaptive response are unclear but warrant further investigation. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Hackney, A. C., Davis, H. C., Lane, A. R. Tags: Original Research Source Type: research

Endocrinological and biochemical changes of scorpionism in children in Upper Egypt
Conclusion: Endocrinological changes were common in all children with scorpion envenomation and more obvious in cases of severe envenomation. The released mediators may account for several inflammatory manifestations such as pulmonary edema, myocardial failure, systemic inflammatory response syndrome and multiple organ failure. The use of insulin is recommended in cases of severe envenomation to improve the outcome. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Ahmed, A. E., Abdel-Baseer, K. A., Saad, K., Hassan, A. F., El-Houfey, A. A. Tags: Original Research Source Type: research

Effects of benchmarking on the quality of type 2 diabetes care: results of the OPTIMISE (Optimal Type 2 Diabetes Management Including Benchmarking and Standard Treatment) study in Greece
Conclusion: Benchmarking may comprise a promising tool for improving the quality of T2DM care. Nevertheless, target achievement rates of each, and of all three, quality indicators were suboptimal, indicating there are still unmet needs in the management of T2DM. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Tsimihodimos, V., Kostapanos, M. S., Moulis, A., Nikas, N., Elisaf, M. S. Tags: Original Research Source Type: research

Diet-induced increases in chemerin are attenuated by exercise and mediate the effect of diet on insulin and HOMA-IR
Conclusion: Chronic exercise may attenuate diet-driven increases in circulating chemerin, and the insulin resistance associated with a high-fat diet may be mediated by diet-induced increases in chemerin. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Lloyd, J. W., Zerfass, K. M., Heckstall, E. M., Evans, K. A. Tags: Original Research Source Type: research

Lipid peroxidation, proteins modifications, anti-oxidant enzymes activities and selenium deficiency in the plasma of hashitoxicosis patients
Conclusions: This study shows the presence of an oxidative stress and selenium deficiency in HTX patients and suggests that the hyperthyroid state is strongly implicated in the establishment of this disturbed oxidative profile. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - September 22, 2015 Category: Endocrinology Authors: Mseddi, M., Ben Mansour, R., Mnif, F., Gargouri, B., Abid, M., Guermazi, F., Attia, H., Lassoued, S. Tags: Original Research Source Type: research

Anatomy of success: 100 most cited articles in diabetes research
Conclusion: Our analysis provides an insight on the citation frequency of top cited articles published in diabetes to help recognize the quality of the works, discoveries and the trends steering the study of diabetes. (Source: Therapeutic Advances in Endocrinology and Metabolism)
Source: Therapeutic Advances in Endocrinology and Metabolism - August 4, 2015 Category: Endocrinology Authors: Shuaib, W., Costa, J. L. Tags: Original Research Source Type: research