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Ketamine and other N-methyl-D-aspartate receptor antagonists in the treatment of depression: a perspective review
Current pharmacotherapies for major depressive disorder (MDD) and bipolar depression (BDep) have a distinct lag of onset that can generate great distress and impairment in patients. Furthermore, as demonstrated by several real-world effectiveness trials, their efficacy is limited. All approved antidepressant medications for MDD primarily act through monoaminergic mechanisms, agonists or antagonists with varying affinities for serotonin, norepinephrine and dopamine. The glutamate system has received much attention in recent years as an avenue for developing novel therapeutics. A single subanesthetic dose infusion of the non...
Source: Therapeutic Advances in Chronic Disease - May 1, 2015 Category: Internal Medicine Authors: Iadarola, N. D., Niciu, M. J., Richards, E. M., Vande Voort, J. L., Ballard, E. D., Lundin, N. B., Nugent, A. C., Machado-Vieira, R., Zarate, C. A. Tags: Reviews Source Type: research

The prevalence of vascular calcification in patients with end-stage renal disease on hemodialysis: a cross-sectional observational study
Conclusions: Vascular and valvular calcification are highly prevalent in the hemodialysis population. Peripheral vascular calcification correlates significantly with elevated pulse pressure and can be assessed easily using lateral lumbar X-ray. Further studies investigating the interaction between pulse pressure and development or progression of vascular calcification are of interest. (Source: Therapeutic Advances in Chronic Disease)
Source: Therapeutic Advances in Chronic Disease - May 1, 2015 Category: Internal Medicine Authors: Kraus, M. A., Kalra, P. A., Hunter, J., Menoyo, J., Stankus, N. Tags: Original Research Source Type: research