Case Series Using Montelukast in Patients with Memory Loss and Dementia.
Authors: Rozin SI
Abstract
Cognitive decline and dementia are a growing problem as the population ages. Effective therapies to prevent and treat these problems are limited. Neuro-inflammation has been suggested as a cause of dementia [1]. Montelukast is a leukotriene receptor antagonist used to treat seasonal allergies and asthma. It acts as a cysteinyl leukotriene (CysLT1) receptor antagonist blocking the action of leukotrienes and decreasing inflammation [2]. Animal studies have shown that administering Montelukast improves memory function [3]. This case series of patients in a private Internal Medicine ...
Source: The Open Neurology Journal - June 3, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
"Doctor, I Hear Music": A Brief Review About Musical Hallucinations.
Authors: Alvarez Perez P, Garcia-Antelo MJ, Rubio-Nazabal E
Abstract
Auditory hallucinations are defined as the abnormal perception of sound in the absence of an external auditory stimulus. Musical hallucinations constitute a complex type of auditory hallucination characterized by perception of melodies, music, or songs. Musical hallucinations are infrequent and have been described in 0.16% of a general hospital population. The auditory hallucinations are popularly associated with psychiatric disorders or degenerative neurological diseases but there may be other causes in which the patient evolves favorabl...
Source: The Open Neurology Journal - June 3, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
Specific Effects of Anti-Hypertensive Treatment in an Older Patient with Dementia.
Authors: Zmudka JA, Sérot JM, Dao S, Sorel C, Macaret AS, Balédent O
Abstract
Dementia is one of the most common health problems in the world. Alzheimer's disease (AD) is the most common form of dementia. The presence of vascular risk factors such as hypertension (HT) may increase the risk of AD [1,2]. The relation between blood pressure (BP) and dementia has been the subject of numerous epidemiological studies, midlife HT is a risk factor for dementia and AD [3-7] but the association between HT and risk of dementia is lower in the older population [8]. A fair modulation of an antihypertensive treatment,...
Source: The Open Neurology Journal - June 3, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
An Emerging Natural History in the Development, Mechanisms and Worldwide Prevalence of Major Mental Disorders.
Authors: Pediaditakis N
Abstract
Conciliating recent findings from molecular genetics, evolutionary biology, and clinical observations together point to new understandings regarding the mechanism, development and the persistent worldwide prevalence of major mental disorders (MMDs), which should be considered the result of an evolutionary downside trade off. Temperamental/trait variability, by facilitating choices for individual and group responses, confers robustness flexibility and resilience crucial to success of our species. Extreme temperamental variants, originating evolutionarily from the asocial asp...
Source: The Open Neurology Journal - February 22, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
Beta Blockade and Clinical Outcomes in Aneurysmal Subarachnoid Hemorrhage.
CONCLUSION: Post-admission beta blockade in aneurysmal subarachnoid hemorrhage patients was associated with increased incidence of vasospasm. However, despite the increased occurrence of vasospasm, beta blockers were associated with improved discharge characteristics and fewer deaths.
PMID: 28217182 [PubMed - in process] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - February 22, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
Affection of the Respiratory Muscles in Combined Complex I and IV Deficiency.
CONCLUSION: Mitochondrial myopathy due to a combined complex I+IV defect with predominant affection of the extra-ocular muscles may progress to involvement of the limb-girdle, axial and respiratory muscles resulting in muscular respiratory insufficiency. In patients with mitochondrial myopathy, neuropathy and elevated cerebrospinal fluid protein, immunoglobulins may be beneficial even for respiratory functions.
PMID: 28217183 [PubMed - in process] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - February 22, 2017 Category: Neurology Tags: Open Neurol J Source Type: research
Functional and Genomic Features of Human Genes Mutated in Neuropsychiatric Disorders.
CONCLUSION: These results represent one of the first analyses of enrichment of functional categories of genes known to harbor mutations for NPD. These findings could be useful for a future creation of computational tools for prioritization of novel candidate genes for NPD.
PMID: 27990183 [PubMed - in process] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - December 20, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
The Role of the Iron Stain in Assessing Intracranial Hemorrhage.
In conclusion, the Prussian Blue reaction was unreliable as an indicator of timing in intracranial hemorrhage. The use of the Prussian blue reaction as an independent indicator of chronicity is therefore not valid and can be misleading. Caution is indicated when employing iron staining for timing purposes, as its only use is to highlight, as opposed to identify, pre-existing lesions. With respect to brain lesions, the Prussian blue reaction should not be used in place of the clinical timing of the neurologic decline, or clinical data that is otherwise more accurate and less susceptible to false positive results.
PM...
Source: The Open Neurology Journal - November 21, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Molecular Mapping Alzheimer's Disease: MALDI Imaging of Formalin-fixed, Paraffin-embedded Human Hippocampal Tissue.
Authors: Kelley AR, Perry G, Bethea C, Castellani RJ, Bach SB
Abstract
A method for the molecular mapping of formalin-fixed, paraffin-embedded human hippocampal tissue affected by Alzheimer's disease (AD) is presented. This approach utilizes imaging mass spectrometry (IMS) with matrix-assisted laser desorption/ionization (MALDI). The usefulness of this technique in comparing diseased versus nor mal tissue at the molecular level while continuing to maintain topological and morphological integrity is evident in the preliminary findings. The critical correlation of the deparaffination, washing, matrix deposit...
Source: The Open Neurology Journal - November 17, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Review: Cav2.3 R-type Voltage-Gated Ca(2+) Channels - Functional Implications in Convulsive and Non-convulsive Seizure Activity.
CONCLUSION: Development of novel Cav2.3 specific modulators can be effective in the pharmacological treatment of epilepsies and other neurological disorders.
PMID: 27843503 [PubMed - in process] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - November 17, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Relationship Between Patients with Clinical Auditory Neuropathy Spectrum Disorder and Mutations in Gjb2 Gene.
CONCLUSION: Mutations in GJB2 gene mutations were found in 7.5% of the patients with ANSD. We found no relationship between patients with clinical auditory neuropathy spectrum disorder and mutations in GJB2 gene (p>0.05).
PMID: 27843504 [PubMed - in process] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - November 17, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Osteopathic Manual Treatment for Amyotrophic Lateral Sclerosis: A Feasibility Pilot Study.
CONCLUSION: OMT was found feasible, safe and satisfactory in ALS. The lack of secondary aim differences can be due to the limited sample size. OMT could be an interesting option to explore in ALS.
PMID: 27651843 [PubMed] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - September 23, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Are Temporal Differences in GDNF and NOS Isoform Induction Contributors to Neurodegeneration? A Fluorescence Microscopy-Based Study.
CONCLUSION: Our findings suggest that the protective abilities of GDNF to combat neural destruction are not available rapidly enough, and do not remain at sufficiently high levels long enough to assert its protective effects. (250).
PMID: 27651844 [PubMed] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - September 23, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Polio Patients in Northern Italy, a 50 Year Follow-up.
CONCLUSION: Female gender, fatigue and wheelchair dependency were significantly more common in PPS while pain was common in both groups.
PMID: 27651845 [PubMed] (Source: The Open Neurology Journal)
Source: The Open Neurology Journal - September 23, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
Oxidative Stress Induces Senescence in Cultured RPE Cells.
Authors: Aryan N, Betts-Obregon BS, Perry G, Tsin AT
Abstract
The aim of this research is to determine whether oxidative stress induces cellular senescence in human retinal pigment epithelial cells. Cultured ARPE19 cells were subjected to different concentrations of hydrogen peroxide to induce oxidative stress. Cells were seeded into 24-well plates with hydrogen peroxide added to cell medium and incubated at 37°C + 5% CO2 for a 90-minute period [at 0, 300, 400 and 800 micromolar (MCM) hydrogen peroxide]. The number of viable ARPE19 cells were recorded using the Trypan Blue Dye Exclusion Method and cell se...
Source: The Open Neurology Journal - September 23, 2016 Category: Neurology Tags: Open Neurol J Source Type: research
