Key populations and power: people-centred social innovation in Asian HIV services
Publication date: Available online 7 December 2019Source: The Lancet HIVAuthor(s): Fan Yang, Rena Janamnuaysook, Mark A Boyd, Nittaya Phanuphak, Joseph D TuckerSummaryKey populations increasingly lead the design, implementation, and evaluation of HIV services, which provides an opportunity to make them more people-centred. Despite many challenges, a strong argument that these populations must have a greater role in HIV service planning, development, and delivery worldwide exists. This Viewpoint focuses on Asia, where key populations have advocated for legal reform, engaged vulnerable groups to decrease stigma, co-created i...
Source: The Lancet HIV - December 7, 2019 Category: Infectious Diseases Source Type: research
Circulating resistance to first-line HIV drug regimens
Publication date: Available online 7 December 2019Source: The Lancet HIVAuthor(s): Collins C Iwuji, Mark J Siedner (Source: The Lancet HIV)
Source: The Lancet HIV - December 7, 2019 Category: Infectious Diseases Source Type: research
Evaluation of the management of pretreatment HIV drug resistance by oligonucleotide ligation assay: a randomised controlled trial
Publication date: Available online 7 December 2019Source: The Lancet HIVAuthor(s): Michael H Chung, Christine J McGrath, Ingrid A Beck, Molly Levine, Ross S Milne, Isaac So, Nina Andersen, Sandra Dross, Robert W Coombs, Bhavna Chohan, Nelly Yatich, Catherine Kiptinness, Samah R Sakr, James N Kiarie, Lisa M FrenkelSummaryBackgroundAlthough experts have recommended testing for pretreatment drug resistance (PDR) before antiretroviral therapy (ART) initiation, there is little evidence to support its implementation. We aimed to establish whether an inexpensive point mutation assay can improve virological suppression by identify...
Source: The Lancet HIV - December 7, 2019 Category: Infectious Diseases Source Type: research
Pre-exposure prophylaxis uptake and early continuation among pregnant and post-partum women within maternal and child health clinics in Kenya: results from an implementation programme
Publication date: Available online 5 December 2019Source: The Lancet HIVAuthor(s): John Kinuthia, Jillian Pintye, Felix Abuna, Kenneth K Mugwanya, Harison Lagat, Dickens Onyango, Emily Begnel, Julia Dettinger, Jared M Baeten, Grace John-Stewart, Ajode C Aquino, Steve J Ochieng, Alice M Lipesa, Ambia L Naidu, Anastacia Kamau, Anne W Njoroge, Bernard O Okeah, Cecilia B Makabwa, Celestine C Atieno, Christine K IreriSummaryBackgroundPregnant women in settings with high HIV prevalence are at increased risk of HIV acquisition and subsequent vertical transmission. We implemented and evaluated a novel programme to provide pre-expo...
Source: The Lancet HIV - December 6, 2019 Category: Infectious Diseases Source Type: research
PrEP implementation in pregnant and post-partum women
Publication date: Available online 5 December 2019Source: The Lancet HIVAuthor(s): Dvora Joseph Davey, Landon Myer, Thomas Coates (Source: The Lancet HIV)
Source: The Lancet HIV - December 6, 2019 Category: Infectious Diseases Source Type: research
Correction to Lancet HIV 2019; 6: e760–68
Publication date: December 2019Source: The Lancet HIV, Volume 6, Issue 12Author(s): (Source: The Lancet HIV)
Source: The Lancet HIV - December 3, 2019 Category: Infectious Diseases Source Type: research
People ageing with HIV face an uncertain future
Publication date: December 2019Source: The Lancet HIV, Volume 6, Issue 12Author(s): Talha Burki (Source: The Lancet HIV)
Source: The Lancet HIV - December 3, 2019 Category: Infectious Diseases Source Type: research
HIV immunoprophylaxis: preparing the pathway from proof of concept to policy decision and use
Publication date: Available online 27 November 2019Source: The Lancet HIVAuthor(s): Johan Vekemans, William Snow, Patricia E Fast, Rachel Baggaley, Kundai Chinyenze, Martin H Friede, Peter Godfrey-Faussett, David C Kaslow, Helen ReesSummaryVarious long-awaited efficacy studies of vaccines and broadly neutralising antibodies for prevention of HIV are now well underway in highly endemic settings. One broadly neutralising monoclonal antibody is being assessed for proof of concept, and combinations are in the pipeline. Two multicomponent prime-and-boost vaccine regimens are being evaluated, one of which is designed for global ...
Source: The Lancet HIV - November 28, 2019 Category: Infectious Diseases Source Type: research
On-demand pre-exposure prophylaxis with tenofovir disoproxil fumarate plus emtricitabine among men who have sex with men with less frequent sexual intercourse: a post-hoc analysis of the ANRS IPERGAY trial
Publication date: Available online 26 November 2019Source: The Lancet HIVAuthor(s): Guillemette Antoni, Cécile Tremblay, Constance Delaugerre, Isabelle Charreau, Eric Cua, Daniela Rojas Castro, François Raffi, Julie Chas, Thomas Huleux, Bruno Spire, Catherine Capitant, Laurent Cotte, Laurence Meyer, Jean-Michel Molina, Jean-Pierre Aboulker, Nathalie Bajos, Jean-Guy Baril, Michel Besnier, Johan Binesse, Diane CaretteSummaryBackgroundANRS IPERGAY found that on-demand pre-exposure prophylaxis (PrEP) with oral tenofovir disoproxil fumarate plus emtricitabine was associated with an 86% relative reduction of HIV-1 incidence co...
Source: The Lancet HIV - November 27, 2019 Category: Infectious Diseases Source Type: research
On-demand PrEP efficacy: forgiveness or timely dosing?
Publication date: Available online 26 November 2019Source: The Lancet HIVAuthor(s): Jean-Jacques Parienti (Source: The Lancet HIV)
Source: The Lancet HIV - November 27, 2019 Category: Infectious Diseases Source Type: research
Stigma reduction interventions in people living with HIV to improve health-related quality of life
Publication date: Available online 24 November 2019Source: The Lancet HIVAuthor(s): Galit Zeluf Andersson, Maria Reinius, Lars E Eriksson, Veronica Svedhem, Farhad Mazi Esfahani, Keshab Deuba, Deepa Rao, Goodluck Willey Lyatuu, Danielle Giovenco, Anna Mia EkströmSummaryAs the UNAIDS 90-90-90 targets for people living with HIV are increasingly being reached in many contexts, health-related quality of life, the so-called fourth 90, warrants special attention. HIV-related stigma and discrimination are major barriers for overall health-related quality of life despite impressive clinical and virological improvements in HIV car...
Source: The Lancet HIV - November 26, 2019 Category: Infectious Diseases Source Type: research
Patient-reported outcomes to enhance person-centred HIV care
Publication date: Available online 24 November 2019Source: The Lancet HIVAuthor(s): Meaghan Kall, Fabienne Marcellin, Richard Harding, Jeffrey V Lazarus, Patrizia CarrieriSummaryQuality of life has been proposed as the fourth 90 to complement the UNAIDS 90-90-90 targets to monitor the global HIV response, highlighting a need to address the holistic needs of people living with HIV beyond viral suppression. This proposal has instigated a wider discussion about the use of patient-reported outcomes (PROs) to improve the treatment and care of an ageing HIV population with increasing comorbidities and a disproportionate burden o...
Source: The Lancet HIV - November 26, 2019 Category: Infectious Diseases Source Type: research
Beyond HIV viral suppression: an African perspective
Publication date: Available online 24 November 2019Source: The Lancet HIVAuthor(s): David Musoke Serwadda (Source: The Lancet HIV)
Source: The Lancet HIV - November 26, 2019 Category: Infectious Diseases Source Type: research
Living well with HIV
Publication date: Available online 24 November 2019Source: The Lancet HIVAuthor(s): The Lancet HIV (Source: The Lancet HIV)
Source: The Lancet HIV - November 26, 2019 Category: Infectious Diseases Source Type: research
Reorienting health systems to care for people with HIV beyond viral suppression
Publication date: Available online 24 November 2019Source: The Lancet HIVAuthor(s): Kelly Safreed-Harmon, Jane Anderson, Natasha Azzopardi-Muscat, Georg M N Behrens, Antonella d'Arminio Monforte, Udi Davidovich, Julia del Amo, Meaghan Kall, Teymur Noori, Kholoud Porter, Jeffrey V LazarusSummaryThe effectiveness of antiretroviral therapy and its increasing availability globally means that millions of people living with HIV now have a much longer life expectancy. However, people living with HIV have disproportionately high incidence of major comorbidities and reduced health-related quality of life. Health systems must respon...
Source: The Lancet HIV - November 26, 2019 Category: Infectious Diseases Source Type: research
