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Chronic obstructive pulmonary disease: Is there a case for early intervention?
Publication date: 20 December 2004 Source:The American Journal of Medicine Supplements, Volume 117, Issue 12, Supplement 1 Author(s): Scott D. Ramsey , Sean D. Sullivan Chronic obstructive pulmonary disease (COPD) is a highly prevalent condition that represents a significant economic burden to society. Early diagnosis of COPD offers the best opportunity to slow the progression of the disease through smoking cessation. Aggressive medical management of COPD for patients diagnosed at a moderate or severe stage is likely to be attractive from an economic standpoint, although prospective studies are needed to validate cur...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Conclusion: How primary care physicians can help their patients with migraine
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Elizabeth W. Loder , Richard B. Lipton (Source: The American Journal of Medicine Supplements)
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Evaluating the safety and tolerability profile of acute treatments for migraine
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Vincent T. Martin , James A. Goldstein Among the medications that have been used as acute treatments for migraine are nonspecific agents, including nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics (either single or combination), and narcotics, as well as migraine-specific medications, including ergot alkaloids and triptans (5-hydroxytryptamine 1B/1D agonists). All of these drugs have side effects that vary in type and severity. Side effects of nonspecific medications, including gastrointestin...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Evaluating the triptans
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Ninan T. Mathew , Elizabeth W. Loder The debilitating effect of migraine has fueled the search for more specific agents to treat its characteristic and associated symptoms. Second-generation oral triptans have shown an improved efficacy profile in comparison with the pioneer sumatriptan and with the over-the-counter medications and prescription analgesics that have been staples of migraine treatment. Although all triptans exert effects through the 5-hydroxytryptamine 1B/1D receptors, each triptan has ...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Initiating and optimizing acute therapy for migraine: The role of patient-centered stratified care
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Merle Diamond , Roger Cady Migraine is a chronic, intermittently disabling condition that affects physical, mental, and social aspects of health-related quality of life. Because patients seeking assistance with migraine most often present to primary care providers, these healthcare professionals play critical roles in the diagnosis and treatment process. A comprehensive migraine management plan involves a partnership between the patient and healthcare professional where treatment goals and strategies ...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Identifying migraine in primary care settings
Publication date: March 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 1 Author(s): Richard Sadovsky , David W. Dodick Migraine disorders are largely unrecognized and untreated, despite the heavy burden they impose on individuals and society. Studies have shown that the symptom severity and disability associated with undiagnosed migraine are as burdensome as those associated with diagnosed migraine. Of those persons with migraine identified in population-based surveys, many were previously unaware that they had migraine. Furthermore, coexisting headache types and comorbid conditions ...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

The epidemiology of migraine
This article provides a review of the epidemiology and risk factors for migraine in population studies, as well as patterns for healthcare use. The burden and costs of migraine, as well as risk factors for disease progression, are also discussed. Although migraine is a remarkably common cause of temporary disability, many persons with migraine, even those with disabling headache, have never consulted a physician for the problem. Prevalence is highest in women, in persons between the ages of 25 and 55 years, and, at least in the United States, in individuals from lower income households. However, prevalence is high in group...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

CME section
Publication date: April 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 2 (Source: The American Journal of Medicine Supplements)
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Metabolic syndrome and cardiovascular disease in patients with human immunodeficiency virus
Publication date: April 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 2 Author(s): Steven K. Grinspoon Use of highly active antiretroviral therapy (HAART) for the treatment of human immunodeficiency virus (HIV) infection is associated with the development of cardiovascular risk factors, including dyslipidemia, insulin resistance, fat redistribution, and hypertension. The results of the Data Collection on Adverse Events of Anti-HIV Drugs study showed that HAART therapy is associated with a 26% relative risk increase in the rate of myocardial infarction per year of HAART exposure. A nu...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Metabolic issues and cardiovascular disease in patients with psychiatric disorders
Publication date: April 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 2 Author(s): Daniel E. Casey Individuals with psychiatric disorders tend to have excessive morbidity. They typically have high rates of respiratory illnesses, infectious diseases, substance abuse (including smoking), obesity, diabetes mellitus, and cardiovascular disease (CVD). Persons with schizophrenia and affective disorders also have a high prevalence of risk factors for CVD, such as diabetes and obesity, which are on the order of 1.5 to 2.0 times higher than in the general population; this translates into incr...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Evaluation of the patient with diabetes mellitus and suspected coronary artery disease
In conclusion, MPI provides clinicians with an important diagnostic tool, because it offers perfusion as well as functional information for diagnosis and risk stratification in patients with diabetes. These capabilities facilitate decision making regarding the appropriateness of medical therapy or surgical intervention in these individuals. (Source: The American Journal of Medicine Supplements)
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

Epidemiology of diabetes mellitus and associated cardiovascular risk factors: Focus on human immunodeficiency virus and psychiatric disorders
Publication date: April 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 2 Author(s): Paul Zimmet Type 2 diabetes mellitus and obesity have reached epidemic proportions in many developing and developed nations, leading to talk of the “twin epidemics.” The latest projections from the International Diabetes Federation suggest that 190 million people worldwide currently have type 2 diabetes. In addition, ≥300 million people worldwide have impaired glucose tolerance (IGT). These statistics represent an epidemic of major proportions—possibly the largest epidemic in human history—in...
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research

CME information
Publication date: April 2005 Source:The American Journal of Medicine Supplements, Volume 118, Supplement 2 (Source: The American Journal of Medicine Supplements)
Source: The American Journal of Medicine Supplements - November 6, 2014 Category: Drugs & Pharmacology Source Type: research