Evaluation of Macrocytic Anemias
Macrocytic anemia, defined as an MCV greater or equal to 100 fL in adults, has a narrow differential diagnosis that requires evaluation of the peripheral blood smear as well as additional laboratory testing taken in conjunction with clinical information that includes patient history and physical examination findings. This review is an update on the approach to a patient with macrocytic anemia with attention paid to the differentiation of megaloblastic and non-megaloblastic macrocytic anemias. Critical to the determination of the diagnosis is the judicious use of laboratory testing and the evaluation of those findings in co...
Source: Seminars in Hematology - June 30, 2015 Category: Hematology Authors: Ralph Green, Denis M. Dwyre Source Type: research
Anemia as the Main Manifestation of Mds
Myelodysplastic syndromes (MDS) are a constellation of different diseases sharing anemia in the great majority of cases, and this cytopenia defines these pathologies and their most dramatic clinical manifestations.Anemia in MDS is due to ineffective erythropoiesis, with a high degree of apoptosis of marrow erythroid progenitors. These progenitors show distinctive dysplastic features that consent diagnosis, and are recognizable and differentiated, although not easily, from other morphologic alterations present in other types of anemia. (Source: Seminars in Hematology)
Source: Seminars in Hematology - June 30, 2015 Category: Hematology Authors: Valeria Santini Source Type: research
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Source: Seminars in Hematology - June 23, 2015 Category: Hematology Source Type: research
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(Source: Seminars in Hematology)
Source: Seminars in Hematology - June 23, 2015 Category: Hematology Source Type: research
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Source: Seminars in Hematology - June 23, 2015 Category: Hematology Source Type: research
