The impact of elevated thyroid stimulating hormone on female subfertility
Conclusions
We found an association between elevated TSH and the decreased rate of clinical pregnancy. This might be related to an ovulatory disorder and pathophysiology of unexplained infertility. These results may reinforce the usefulness of TSH screening in infertility population. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - August 12, 2015 Category: OBGYN Source Type: research
The effects of platelet lysate on maturation, fertilization and embryo development of NMRI mouse oocytes at germinal vesicle stage
Conclusions
The results of this study indicated that platelet lysate could improve the maturation rate in the absence of granulosa cells compared to media with FBS. This extract also had positive effects on fertilization and embryo development. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - August 7, 2015 Category: OBGYN Source Type: research
An evaluation of the Gifu Model in a trial for a new regional oncofertility network in Japan, focusing on its necessity and effects
Conclusions
The GPOFS as the first regional oncofertility network in Japan has just started and may be working to help both AYA cancer patients and their oncologists. The nationwide establishment of the regional oncofertility network model could help both AYA cancer patients and oncologists. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - August 7, 2015 Category: OBGYN Source Type: research
Cryopreservation of testis tissues and in vitro spermatogenesis
Abstract
Cancer treatments, either chemo- or radiotherapy, may cause severe damage to gonads which could lead to the infertility of patients. In post-pubertal male patients, semen cryopreservation is recommended to preserve the potential to have their own biological children in the future; however, it is not applicable to prepubertals. The preservation of testis tissue which contains spermatogonial stem cells (SSCs) but not sperm would be an alternative measure. The tissues or SSCs have to be transplanted back into patients to obtain sperm; however, this procedure remains experimental, invasive, an...
Source: Reproductive Medicine and Biology - August 5, 2015 Category: OBGYN Source Type: research
Successful pregnancy by vitrified–warmed embryo transfer for a woman with Kallmann syndrome
Conclusion
This is the first report of a healthy delivery after vitrified–warmed embryo transfer for a woman with Kallmann syndrome. Our experience suggests that ICSI and vitrified–warmed embryo transfer are effective for women with Kallmann syndrome. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - July 22, 2015 Category: OBGYN Source Type: research
Preimplantation genetic diagnosis/screening by comprehensive molecular testing
Abstract
Although embryo screening by preimplantation genetic diagnosis (PGD) has become the standard technique for the treatment of recurrent pregnancy loss in couples with a balanced gross chromosomal rearrangement, the implantation and pregnancy rates of PGD using conventional fluorescence in situ hybridization (FISH) remain suboptimal. Comprehensive molecular testing, such as array comparative genomic hybridization and next-generation sequencing, can improve these rates, but amplification bias in the whole genome amplification method remains an obstacle to accurate diagnosis. Recent advances in amplif...
Source: Reproductive Medicine and Biology - July 14, 2015 Category: OBGYN Source Type: research
Acknowledgments
(Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - July 14, 2015 Category: OBGYN Source Type: research
Conceptus implantation and placentation: molecules related to epithelial–mesenchymal transition, lymphocyte homing, endogenous retroviruses, and exosomes
Abstract
Processes of conceptus implantation and placentation, unique to mammalian reproduction, have been extensively studied. It was once thought that processes of these events varied greatly, notably between invasive and noninvasive modes of implantation and/or placentation. Regardless of the mode of implantation, however, physiological and biochemical processes in conceptus implantation to the maternal endometrium including the kinds of gene expression and their products are now considered not to differ so much. Recent progress has identified that in addition to the hormones, cytokines, proteases and ...
Source: Reproductive Medicine and Biology - July 12, 2015 Category: OBGYN Source Type: research
Derivation of integration-free iPSCs from a Klinefelter syndrome patient
Conclusions
KS patient-derived iPS cells that could differentiate into cardiomyocyte-like cells were established. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - July 2, 2015 Category: OBGYN Source Type: research
Predictive factors of successful sperm retrieval on microdissection testicular sperm extraction in Japanese men
Conclusions
Spermatozoa are significantly less likely to be successfully retrieved by micro-TESE in men with idiopathic azoospermia. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - June 23, 2015 Category: OBGYN Source Type: research
A multi-center, randomized, open-label, parallel group study of a natural micronized progesterone vaginal tablet as a luteal support agent in Japanese women undergoing assisted reproductive technology
Conclusions
FE 999913 was useful in this trial from the aspects of sufficient supplementation of progesterone, comparable pregnancy rate with that in clinical practice in Japan, and safety.
Clinical trial registration
ClinicalTrials.gov identifier: NCT01710514. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - June 14, 2015 Category: OBGYN Source Type: research
The effect of moderate to severe endometriosis on expression of growth differentiation factor-9 mRNA in human granulosa cells under controlled ovarian hyperstimulation
Conclusions
Moderate to severe endometriosis can significantly reduce GDF-9 mRNA expression in the granulosa cells of patients with the disease compared with those without, thus causing poor oocyte maturation and lower embryo quality. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - May 19, 2015 Category: OBGYN Source Type: research
A case of primary ciliary dyskinesia treated with ICSI using testicular spermatozoa: case report and a review of the literature
Conclusions
TESE-ICSI for PCD may improve the fertilization rate compared to EJ-ICSI. However, it does not necessarily improve the pregnancy outcome for a patient with primary ciliary dyskinesia. (Source: Reproductive Medicine and Biology)
Source: Reproductive Medicine and Biology - May 19, 2015 Category: OBGYN Source Type: research
Oocyte aging underlies female reproductive aging: biological mechanisms and therapeutic strategies
Abstract
In recent years, postponement of marriage and childbearing in women of reproductive age has led to an increase in the incidence of age-related infertility. The reproductive aging process in women is assumed to occur due to a decrease in both the quantity and quality of the oocytes, with the ultimate result being a decline in fecundity. This age-related decline in fecundity is strongly dependent on oocyte quality, which is critical for fertilization and subsequent embryo development. Aged oocytes display increased chromosomal abnormality and dysfunction of cellular organelles, both of which factor...
Source: Reproductive Medicine and Biology - May 8, 2015 Category: OBGYN Source Type: research
Making the first decision: lessons from the mouse
Abstract
Pre-implantation development encompasses a period of 3–4 days over which the mammalian embryo has to make its first decision: to separate the pluripotent inner cell mass (ICM) from the extra-embryonic epithelial tissue, the trophectoderm (TE). The ICM gives rise to tissues mainly building the body of the future organism, while the TE contributes to the extra-embryonic tissues that support embryo development after implantation. This review provides an overview of the cellular and molecular mechanisms that control the critical aspects of this first decision, and highlights the role of critical e...
Source: Reproductive Medicine and Biology - April 16, 2015 Category: OBGYN Source Type: research
