Comparison of the restricted mean survival time with the hazard ratio in superiority trials with a time ‐to‐event end point
Pharmaceutical Statistics, EarlyView. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 28, 2017 Category: Statistics Source Type: research
Use of a historical control group in a noninferiority trial assessing a new antibacterial treatment: A case study and discussion of practical implementation aspects
Pharmaceutical Statistics,Volume 17, Issue 2, Page 169-181, March/April 2018. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 28, 2017 Category: Statistics Source Type: research
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Pharmaceutical Statistics, Ahead of Print. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 28, 2017 Category: Statistics Source Type: research
Comparison of the restricted mean survival time with the hazard ratio in superiority trials with a time ‐to‐event end point
With the emergence of novel therapies exhibiting distinct mechanisms of action compared to traditional treatments, departure from the proportional hazard (PH) assumption in clinical trials with a time‐to‐event end point is increasingly common. In these situations, the hazard ratio may not be a valid statistical measurement of treatment effect, and the log‐rank test may no longer be the most powerful statistical test. The restricted mean survival time (RMST) is an alternative robust and clinically interpretable summary measure that does not rely on the PH assumption. We conduct extensive simulations to evaluate the pe...
Source: Pharmaceutical Statistics - December 28, 2017 Category: Statistics Authors: Bo Huang, Pei ‐Fen Kuan Tags: MAIN PAPER Source Type: research
Basic Statistics and Pharmaceutical Statistical Applications, Third Edition. James E. De Muth (2014). ISBN: 9781466596733, 821 pages, hardback. Price: $99.00 (USD) / £67.99 (GBP)
Pharmaceutical Statistics, EarlyView. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 19, 2017 Category: Statistics Source Type: research
Response ‐adaptive designs for binary responses: How to offer patient benefit while being robust to time trends?
Pharmaceutical Statistics,Volume 17, Issue 2, Page 182-197, March/April 2018. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 19, 2017 Category: Statistics Source Type: research
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Pharmaceutical Statistics, Ahead of Print. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 19, 2017 Category: Statistics Source Type: research
Basic Statistics and Pharmaceutical Statistical Applications, Third Edition. James E. De Muth (2014). ISBN: 9781466596733, 821 pages, hardback. Price: $99.00 (USD) / £67.99 (GBP)
(Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - December 19, 2017 Category: Statistics Authors: Emma Yu Wang Tags: BOOK REVIEW Source Type: research
Sample size re ‐estimation incorporating prior information on a nuisance parameter
Pharmaceutical Statistics,Volume 17, Issue 2, Page 126-143, March/April 2018. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - November 27, 2017 Category: Statistics Source Type: research
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Pharmaceutical Statistics, Ahead of Print. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - November 27, 2017 Category: Statistics Source Type: research
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Pharmaceutical Statistics,Volume 17, Issue 1, Page 74-89, January/February 2018. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - November 26, 2017 Category: Statistics Source Type: research
Design considerations in clinical trials with cure rate survival data: A case study in oncology
Pharmaceutical Statistics,Volume 17, Issue 2, Page 94-104, March/April 2018. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - November 20, 2017 Category: Statistics Source Type: research
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Pharmaceutical Statistics, Ahead of Print. (Source: Pharmaceutical Statistics)
Source: Pharmaceutical Statistics - November 20, 2017 Category: Statistics Source Type: research
