Only strongly enhanced residual FDG uptake in early response PET (Deauville 5 or qPET ≥ 2) is prognostic in pediatric Hodgkin lymphoma: Results of the GPOH‐HD2002 trial
ConclusionOnly strongly enhanced residual FDG uptake in early response PET (vDS 5 or qPET ≥ 2, respectively) seems to be markedly prognostic in PHL when treatment according to the GPOH‐HD‐2002 protocol is given. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 14, 2018 Category: Cancer & Oncology Authors: L. Kurch,
D. Hasenclever,
R. Kluge,
T. Georgi,
L. Tchavdarova,
M. Golombeck,
O. Sabri,
A. Eggert,
W. Brenner,
K.W. Sykora,
F.M. Bengel,
C. Rossig,
D. K örholz,
M. Schäfers,
T. Feuchtinger,
P. Bartenstein,
R.A. Ammann,
T. Krause,
C. Urb Tags: RESEARCH ARTICLE Source Type: research
Issue Information
Pediatric Blood&Cancer, Volume 66, Issue S1, January 2019. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 13, 2018 Category: Cancer & Oncology Tags: ISSUE INFORMATION Source Type: research
Abstracts from the 34th Annual Meeting of the Histiocyte Society Lisbon, Portugal, October 22 –23, 2018
Pediatric Blood&Cancer, Volume 66, Issue S1, January 2019. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 13, 2018 Category: Cancer & Oncology Tags: ABSTRACTS Source Type: research
Intravenous fosaprepitant for the prevention of chemotherapy ‐induced vomiting in children: A double‐blind, placebo‐controlled, phase III randomized trial
ConclusionAddition of fosaprepitant to ondansetron and dexamethasone improved chemotherapy ‐induced vomiting control in children treated with moderately or highly emetogenic chemotherapy. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 13, 2018 Category: Cancer & Oncology Authors: Venkatraman Radhakrishnan,
Archit Joshi,
Jaikumar Ramamoorthy,
Swaminathan Rajaraman,
Prasanth Ganesan,
Trivadi S. Ganesan,
Manikandan Dhanushkodi,
Tenali G. Sagar Tags: RESEARCH ARTICLE Source Type: research
Treatment and outcome of patients with thoracic tumors of the Ewing sarcoma family: A report from the Cooperative Weichteilsarkom Studiengruppe CWS ‐81, ‐86, ‐91, ‐96, and ‐2002P trials
ConclusionsPositive predictive factors for outcome are age ≤10 years, size ≤5 cm, and localization at the chest wall. Diverse IRS groups require individual treatment. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 12, 2018 Category: Cancer & Oncology Authors: Guido Seitz,
Cristian Urla,
Monika Sparber ‐Sauer,
Andreas Schuck,
Christian Vokuhl,
Bernd Blank,
Thomas Klingebiel,
Bernarda Kazanowska,
Jörg Fuchs,
Ewa Koscielniak Tags: RESEARCH ARTICLE Source Type: research
Management of oral mucositis in pediatric patients receiving cancer therapy: A systematic review and meta ‐analysis
ConclusionThis review provided a comprehensive examination of available options for children who have OM. The results support the possibility of a positive effect of palifermin on reducing OM in children receiving cancer therapy. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 12, 2018 Category: Cancer & Oncology Authors: Fatemeh Mazhari,
Alireza Sarraf Shirazi,
Mahboubeh Shabzendehdar Tags: REVIEW Source Type: research
Physician perspectives on compassionate use in pediatric oncology
ConclusionIdentified perceived and actual barriers to compassionate use application submission suggest pediatric oncologists may benefit from educational resources and support to ensure children with cancer equal access to investigational agents and care. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Scott Moerdler,
Lindy Zhang,
Elena Gerasimov,
Chong Zhu,
Tamar Wolinsky,
Michael Roth,
Nancy Goodman,
Daniel A. Weiser Tags: RESEARCH ARTICLE Source Type: research
CD38 is not expressed in pediatric ALK ‐positive anaplastic large cell lymphoma
Pediatric Blood&Cancer, EarlyView. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Rex K.H. Au ‐Yeung,
Birgit Burkhardt,
Wilhelm Woessmann,
Wolfram Klapper Tags: LETTER TO THE EDITOR Source Type: research
The effect of preoperative chemotherapy on histological subtyping and staging of Wilms tumors: The United Kingdom Children's Cancer Study Group (UKCCSG) Wilms tumor trial 3 (UKW3) experience
ConclusionPCT significantly altered histological features and typing of WTs. It resulted in fewer stage III tumors, and staging discrepancies were equally represented in both groups. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Gordan M. Vujani ć,
Ellen D’Hooghe,
Sergey D. Popov,
Neil J. Sebire,
Anna Kelsey Tags: RESEARCH ARTICLE Source Type: research
Malignant peripheral nerve sheath tumor: Transformation in a patient with neurofibromatosis type 2
AbstractMalignant peripheral nerve sheath tumor (MPNST) is a rare soft ‐tissue sarcoma with an unfavorable prognosis and limited therapeutic options. MPNSTs can be sporadic, but are often associated with neurofibromatosis (NF) 1 and usually arise from preexisting neurofibromas. MPNSTs in patients with NF2 have been reported in only exceedingly rare cases, and the mec hanisms underlying transformation into an MPNST have not been fully elucidated. Here, we describe the clinicopathological and genomic features of a peripheral nerve sheath tumor (PNST), with a primary diagnosis of a neurofibroma, as it transforms into a high...
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Laura Agresta,
Ralph Salloum,
Trent R. Hummel,
Nancy Ratner,
Francesco T. Mangano,
Christine Fuller,
Richard L. McMasters,
Luke Pater,
Blaise V. Jones,
Sara Szabo,
Joseph G. Pressey Tags: BRIEF REPORT Source Type: research
Adolescent survivors ’ information needs for transitions to postsecondary education and employment
ConclusionsAYA survivors and parents lack knowledge necessary to successfully transition to their goals after high school. Greater education is needed. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Marnie Hauff,
Regina Abel,
Juliana Hersh,
Jill Isenberg,
Debra Spoljaric,
Robert J. Hayashi,
Allison A. King Tags: RESEARCH ARTICLE Source Type: research
The utility of routine surveillance screening with magnetic resonance imaging to detect tumor recurrence/progression in children with high ‐grade central nervous system tumors: a systematic review
ConclusionThere is a paucity of evidence to guide clinical practice as to the effectiveness of MRI surveillance in pediatric patients with high ‐grade CNS tumors. These studies do not clearly demonstrate benefit or harm for the practice. With more research needed, there is a role for researchers to build into future trials data collection on surveillance imaging to give more information for the assessment of imaging frequency and duration in asymptomatic patients. This is an important question not only to clinicians and patients and their families but also from a health service resource perspective. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Simon P. Stevens,
Caroline Main,
Simon Bailey,
Barry Pizer,
Martin English,
Bob Phillips,
Andrew Peet,
Shivaram Avula,
Sophie Wilne,
Keith Wheatley,
Pamela R. Kearns,
Jayne S. Wilson Tags: REVIEW Source Type: research
Transarterial radioembolization with yttrium ‐90 of unresectable primary hepatic malignancy in children
ConclusionTARE ‐Y90 of unresectable primary liver malignancy is both technically feasible and demonstrates an anticancer effect, and retreatment is well tolerated. TARE‐Y90 could be considered as adjunctive therapy in pediatric patients with unresectable hepatic malignancies and could be used as a bridge to su rgical resection or liver transplant. More research is required to determine the efficacy of this treatment in children and to define the clinical scenarios where benefit is likely to be optimized. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 8, 2018 Category: Cancer & Oncology Authors: Allison Aguado,
Ross Ristagno,
Alexander J. Towbin,
Anita Gupta,
Sinisa Haberle,
Zhihua Qi,
Manish N. Patel,
Kamlesh U. Kukreja,
Gregory M. Tiao,
James I. Geller Tags: RESEARCH ARTICLE Source Type: research
Pediatric pain screening identifies youth at risk of chronic pain in sickle cell disease
Pediatric Blood&Cancer, EarlyView. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 5, 2018 Category: Cancer & Oncology Authors: Soumitri Sil,
Lindsey L. Cohen,
Carlton Dampier Source Type: research
How I approach iron deficiency with and without anemia
Pediatric Blood&Cancer, EarlyView. (Source: Pediatric Blood and Cancer)
Source: Pediatric Blood and Cancer - November 5, 2018 Category: Cancer & Oncology Authors: Jacquelyn M. Powers,
Sarah H. O'Brien Source Type: research
