Correction of Hyper- and Hyponatraemia during Continuous Renal Replacement Therapy
Conclusion: During continuous RRT, the step-wise adjustment of [Na+] of dialysate/replacement fluids offers a safe and reliable method to correct sodium disorders.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 9, 2015 Category: Urology & Nephrology Source Type: research
Effects of Sleepiness on Survival in Japanese Hemodialysis Patients: J-DOPPS Study
Sleep disorder and poor sleep quality are common in chronic hemodialysis (HD) patients. They have been claimed as a cause of morbidity and mortality. The relationship between the degree of sleepiness and survival has not been studied. We studied the degree of sleepiness in 1,252 adult HD patients (age ≥20 years) recruited into the Dialysis Outcomes Practice Pattern Study in Japan (J-DOPPS III), using the Japanese version of the Epworth Sleepiness Scale (JESS) questionnaire. Demographic data were presented for three subgroups: low, intermediate, and high JESS score. Cox proportional hazard regression analysis was performe...
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research
Compared Decline of Residual Kidney Function in Patients Treated with Automated Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis: A Multicenter Study
Conclusions: Starting PD patients directly on APD is associated with a faster decline of RKF and a higher risk of developing anuria than doing so on CAPD. This detrimental effect is more marked in patients initiating PD with lower levels of RKF.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research
The 99mTc-DTPA Urinary Clearance Method May Be Preferable to the Plasma Disappearance Method for Assessing Glomerular Filtration Rate in Diabetic Nephropathy
In this study, we compared urinary and plasma iGFR methodologies in patients with diabetic nephropathy. Methods: A total of 147 patients from 3 sites in the Diabetic Intervention with Vitamins to Improve Nephropathy (DIVINe) trial provided 213 sets of urine and blood collections, at baseline, 18 and 36 months. Results: The mean (with standard deviation) plasma iGFR of 60.7 (24.9) ml/min/1.73 m2 compared to urinary iGFR of 52.0 (28.0) ml/min/1.73 m2 was statistically significant (p value (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research
Ectopic Expression of Fatty Acid-Binding Protein 4 in the Glomerulus Is Associated with Proteinuria and Renal Dysfunction
Conclusion: Ectopic FABP4 expression in the glomerulus is induced by renal diseases and is closely associated with proteinuria and renal dysfunction.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 8, 2015 Category: Urology & Nephrology Source Type: research
Therapeutic Advances in the Treatment of Polycystic Kidney Disease
The spectrum of polycystic kidney disease (PKD) comprises a family of inherited syndromes defined by renal cyst formation and growth, progressive renal function loss and variable extrarenal manifestations. The most common form, autosomal-dominant PKD is caused by mutations in one of two genes, PKD1 or PKD2. Recent developments in genomic and proteomic medicine have resulted in the discovery of novel genes implicated in the wide variety of less frequent, recessive PKD syndromes. Cysts are the disease, and overall cystic burden, measured by MRI as total kidney volume, is being established as the best available biomarker of d...
Source: Nephron Clinical Practice - January 6, 2015 Category: Urology & Nephrology Source Type: research
Predictors of Hyperkalemia Risk after Hypertension Control with Aldosterone Blockade according to the Presence or Absence of Chronic Kidney Disease
Conclusion: Spironolactone was well tolerated by selected CKD patients. The risk of serious hyperkalemia or a significant reduction of eGFR appears to be low. Strict monitoring over the first month of treatment followed by standard surveillance for angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers is suggested.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - January 6, 2015 Category: Urology & Nephrology Source Type: research
Uremic Toxins and Their Effects on Multiple Organ Systems
Nearly all body organs and systems are affected by the toxicity of uremic compounds retained in the course of renal dysfunction. Knowledge about the origin, chemical structure and composition of the retained endogenous substances responsible for these symptoms is far from complete. Organic retention solutes present a great variety of properties which makes their accurate classification extremely difficult. Their potential toxicity remains to be elucidated with meticulous observation of clearly formulated rules guiding the process. Toxicity assessment is a complex process because not just one but several retained compounds ...
Source: Nephron Clinical Practice - December 19, 2014 Category: Urology & Nephrology Source Type: research
Safety and Effectiveness of a 2009 H1N1 Vaccine in Chronic Kidney Disease Children
Conclusion: This study demonstrated a high level of immunogenicity and safety of an (H1N1) 2009 influenza vaccine in children with CKD.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 19, 2014 Category: Urology & Nephrology Source Type: research
A Low-Salt Diet Increases the Estimated Net Endogenous Acid Production in Nondiabetic Chronic Kidney Disease Patients Treated with Angiotensin Receptor Blockade
Conclusion: We found that an LSD may increase the NEAP in nondiabetic CKD patients using ARB, which suggests that additional acid producing-protein restriction should be required to prevent the NEAP from rising.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 18, 2014 Category: Urology & Nephrology Source Type: research
Complete Low-Intensity Endurance Training Programme in Haemodialysis Patients: Improving the Care of Renal Patients
Conclusions: (1) The intradialysis training programme improved muscular strength and functional capacity in our HD patients. (2) These results support the benefits of exercise training for HD patients. (3) Nephrologists should consider exercise training as a standard practice for the care of HD patients.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 16, 2014 Category: Urology & Nephrology Source Type: research
Biologic Treatment in Glomerular Disease
(Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 12, 2014 Category: Urology & Nephrology Source Type: research
Chronic Kidney Disease and the Ageing Population
This article reviews the key links between kidney function, age, health and illness, and discusses the implications of the ageing population for the care of people with chronic kidney disease.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 10, 2014 Category: Urology & Nephrology Source Type: research
Sex-Dependent Association between Heart Rate Variability and Pulse Pressure in Haemodialysis Patients
Conclusion: We observed an association between PP and HRV in male HD patients. Sex differences may be important for cardiac risk assessment.Nephron Clin Pract (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 5, 2014 Category: Urology & Nephrology Source Type: research
Mortality and Cardiovascular Morbidity Associated with Haemoglobin Levels: A Pooled Analysis of Randomised Controlled Trials
Conclusion: In multiple analyses from a large programme of prospective clinical trials of ESA treatment, risk of all-cause mortality and cardiovascular morbidity risk was consistently higher at Hb (Source: Nephron Clinical Practice)
Source: Nephron Clinical Practice - December 4, 2014 Category: Urology & Nephrology Source Type: research
