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Nanostructured lipid carriers accumulate in atherosclerotic plaques of ApoE-/- mice
In this study, we evaluated the biodistribution, targeting ability and safety of 64Cu-fonctionalized NLC in atherosclerotic mice. 64Cu-chelating-NLC (51.8±3.1 nm diameter) with low dispersity index (0.066±0.016) were produced by high pressure homogenization at tens-of-grams scale. 24 h after injection of 64Cu-chelated particles in ApoE-/- mice, focal regions of the aorta showed accumulation of particles on autoradiography that colocalized with Oil Red O lipid mapping. Signal intensity was significantly greater in aortas isolated from ApoE-/- mice compared to wild type (WT) control (8.95 [7.58, 10.16] × 108 vs ...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 25, 2020 Category: Nanotechnology Source Type: research

Harnessing Iron-oxide Nanoparticles towards the Improved Bactericidal Activity of Macrophage against Staphylococcus aureus
Publication date: Available online 23 January 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Bing Yu, Zhongxia Wang, Layla Almutairi, Songping Huang, Min-Ho KimAbstractIron oxide nanoparticles (IONPs) have been increasingly used in various biomedical applications in preclinical and clinical settings. Although the interactions of IONPs with macrophages have been well-reported in the context of nanoparticle toxicity, harnessing the capacity of IONPs in reprograming macrophages towards bactericidal activity has not been explored. Here, using an in vitro culture model of macrophages and an in vivo mou...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 25, 2020 Category: Nanotechnology Source Type: research

Doxil chemotherapy plus liposomal P5 immunotherapy decreased myeloid-derived suppressor cells in murine model of breast cancer
In conclusion, the results demonstrated that Doxil® plus liposomal P5 could have a decreasing effect on MDSCs and tumor growth, and it could be beneficial in breast cancer treatment.Graphical Abstract (Source: Nanomedicine: Nanotechnology, Biology and Medicine)
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 11, 2020 Category: Nanotechnology Source Type: research

Enhanced Neuronal Differentiation of Neural Stem Cells with Mechanically Enhanced Touch-Spun Nanofibrous Scaffolds
Publication date: Available online 10 January 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Darya Asheghali, Se-Jun Lee, Andreas Furchner, Alexey Gruzd, Steven Larson, Alexander Tokarev, Seth Stake, Xuan Zhou, Karsten Hinrichs, Lijie G. Zhang, Sergiy MinkoAbstractWe studied NE-4C neural cells differentiation on 2D polycaprolactone (PCL) nanofibrous scaffolds with systematically varied mechanical characteristics of nanofibers while retaining an unchanged fiber alignment, diameter, and chemical composition. Our experiments demonstrated that the nanofibers with enhanced mechanical properties are ben...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 10, 2020 Category: Nanotechnology Source Type: research

A comparative study of the effect of drug hydrophobicity on nanoparticle drug delivery in vivo using two photosensitizers
Publication date: Available online 10 January 2020Source: Nanomedicine: Nanotechnology, Biology and MedicineAuthor(s): Jihwan Son, Donghyun Lee, Jihye Yoo, Changhee Park, Heebeom KooAbstractTo evaluate the effect of drug hydrophobicity on nanoparticle delivery in vivo, we conducted a comparative study using different photosensitizer-loaded poly(lactic-co-glycolic acid) (PLGA) nanoparticles (NPs). Chlorin e6 (Ce6) and pheophorbide a (Pba) with similar structure but different hydrophobicity were loaded into PLGA-NPs separately. We observed release profiles and photodynamic effects in vitro from the resulting Ce6- and Pba-PLG...
Source: Nanomedicine: Nanotechnology, Biology and Medicine - January 10, 2020 Category: Nanotechnology Source Type: research