6{alpha}-Acetoxyanopterine: A Novel Structure Class of Mitotic Inhibitor Disrupting Microtubule Dynamics in Prostate Cancer Cells
This study provides a strong rationale to further develop this novel structure class of microtubule inhibitor for the treatment of malignant disease. Mol Cancer Ther; 16(1); 3–15. ©2016 AACR. (Source: Molecular Cancer Therapeutics)
Source: Molecular Cancer Therapeutics - January 4, 2017 Category: Cancer & Oncology Authors: Levrier, C., Sadowski, M. C., Rockstroh, A., Gabrielli, B., Kavallaris, M., Lehman, M., Davis, R. A., Nelson, C. C. Tags: Small Molecule Therapeutics Source Type: research
Highlights of This Issue
(Source: Molecular Cancer Therapeutics)
Source: Molecular Cancer Therapeutics - January 4, 2017 Category: Cancer & Oncology Tags: Highlights Source Type: research
Acknowledgment to Reviewers
(Source: Molecular Cancer Therapeutics)
Source: Molecular Cancer Therapeutics - November 30, 2016 Category: Cancer & Oncology Tags: Acknowledgment to Reviewers Source Type: research
Correction: Antagonists of IGF: Vitronectin Interactions Inhibit IGF-I-Induced Breast Cancer Cell Functions
(Source: Molecular Cancer Therapeutics)
Source: Molecular Cancer Therapeutics - November 30, 2016 Category: Cancer & Oncology Tags: Correction Source Type: research
Combining Nonclinical Experiments with Translational PKPD Modeling to Differentiate Erlotinib and Gefitinib
We quantitatively compare the efficacy of two approved EGFR tyrosine kinase inhibitors, erlotinib and gefitinib, based on in vivo and in vitro data and show how a modeling approach can be used to scale from animal to humans. Gefitinib shows a higher tumor uptake in cancer patients, and we explored the potential impact on pharmacologic and antitumor activity in in vitro and in xenograft mice. Tumor growth inhibition was monitored, and the pharmacokinetics (PK) in plasma and tumor, as well as temporal changes of phospho-Erk (pErk) signals were examined in patient-derived tumor xenograft mice. These data were integrated in a ...
Source: Molecular Cancer Therapeutics - November 30, 2016 Category: Cancer & Oncology Authors: Eigenmann, M. J., Frances, N., Hoffmann, G., Lave, T., Walz, A.-C. Tags: Models and Technologies Source Type: research
