Pneumococcal Conjugate Vaccine Modulates Macrophage-mediated Innate Immunity in Pneumonia Caused by Streptococcus pneumoniae Following Influenza
Publication date: Available online 17 January 2020Source: Microbes and InfectionAuthor(s): Kazuyuki Mimura, Soichiro Kimura, Chiaki Kajiwara, Sho Nakakubo, Matthew A. Schaller, Yoshikazu Ishii, Theodore J. Standiford, Steven L. Kunkel, Kazuhiro TatedaAbstractPneumococcal conjugate vaccination (PCV) may prevent influenza-related pneumonia, including Streptococcus pneumoniae pneumonia. To investigate PCV efficacy against secondary pneumococcal pneumonia following influenza, PCV was administered intramuscularly 2 and 5 weeks before S. pneumoniae serotype-3 colonization of murine nasopharynges followed by intranasal challenge ...
Source: Microbes and Infection - January 19, 2020 Category: Infectious Diseases Source Type: research
The synergistic triad between microcin, colibactin, and salmochelin gene clusters in uropathogenic Escherichia coli
Publication date: Available online 16 January 2020Source: Microbes and InfectionAuthor(s): Clémence Massip, Camille V. Chagneau, Michèle Boury, Eric OswaldAbstractA functional synergy was previously demonstrated between microcin, salmochelin and colibactin islands in Escherichia coli strains from B2 phylogroup. We aimed to determine this association prevalence in uropathogenic E. coli, and whether it was predictive of the infection severity in a collection of 225 E. coli strains from urinary samples. The high prevalence of this triad, even if it wasn't correlated with infection severity, suggested that it might not be a ...
Source: Microbes and Infection - January 16, 2020 Category: Infectious Diseases Source Type: research
Heterogeneous expression of Pil3 pilus is critical for Streptococcus gallolyticus translocation across polarized colonic epithelial monolayers
We report that S. gallolyticus UCN34 adheres and crosses epithelial monolayers in a Pil3 dependent manner. Confocal images revealed a paracellular passage. Both the Δpil3 mutant and the Pil3+ overexpressing variant were unable to cross Caco-2 and T84 barriers. However, combining live Δpil3 mutant with fixed Pil3+ variant in a 9:1 ratio allowed efficient translocation of the Δpil3 mutant. These results demonstrate that heterogeneous expression of Pil3 plays a key role for UCN34 translocation across the intestinal barrier. Through this skilful strategy, S. gallolyticus probably evade host immune responses. (Source: Microbes and Infection)
Source: Microbes and Infection - December 17, 2019 Category: Infectious Diseases Source Type: research
Expansion and suppressive capacity of regulatory T cells isolated from patients across the leprosy spectrum: a pilot study
Publication date: Available online 16 December 2019Source: Microbes and InfectionAuthor(s): Carol Cardona, Ana P. Vieira, João Avancini, Alberto J.S. Duarte, Maria Angela B. Trindade, Gil BenardAbstractKnowledge of the role of Tregs in the immunopathogenesis of the different clinical outcomes within the leprosy spectrum remains limited due to the lack of studies directly assessing their suppression capacity. We thus tested a protocol to expand Tregs from the peripheral blood of patients across the leprosy spectrum and analyzed their suppressive capacity in autologous TCD4+ responses. Results of these pilot assays show tha...
Source: Microbes and Infection - December 17, 2019 Category: Infectious Diseases Source Type: research
Conquest of Paratyphi
Publication date: Available online 12 December 2019Source: Microbes and InfectionAuthor(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - December 13, 2019 Category: Infectious Diseases Source Type: research
IL-21 is associated with natural resistance to HIV-1 infection in a Colombian HIV exposed seronegative cohort
Publication date: Available online 7 December 2019Source: Microbes and InfectionAuthor(s): Paula Andrea Serna Ortega, Wbeimar Aguilar-Jimenez, Lizdany Florez-Álvarez, Daria Trabattoni, Maria Teresa Rugeles, Mara BiasinAbstractHigher IL-21 levels were associated with natural resistance to HIV infection in an Italian cohort. Thus we wanted to confirm such association in HIV exposed seronegative individuals (HESN) from Colombia. Cells from HESN were less susceptible to infection and expressed higher IL-21 mRNA levels than healthy controls at both baseline and 7-days post-infection; similar results were observed for IL-6, per...
Source: Microbes and Infection - December 7, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: December 2019Source: Microbes and Infection, Volume 21, Issue 10Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - December 5, 2019 Category: Infectious Diseases Source Type: research
The influence of pH on Staphylococcus saprophyticus iron metabolism and the production of siderophores
Publication date: December 2019Source: Microbes and Infection, Volume 21, Issue 10Author(s): Bianca Silva Vieira de Souza, Karla Christina Sousa Silva, Ana Flávia Alves Parente, Clayton Luiz Borges, Juliano Domiraci Paccez, Maristela Pereira, Célia Maria de Almeida Soares, Marcia Giambiagi-deMarval, Mirelle Garcia Silva-Bailão, Juliana Alves Parente-RochaAbstractStaphylococcus saprophyticus is a gram-positive coagulase negative bacteria which shows clinical importance due to its capability of causing urinary tract infections (UTI), as well as its ability to persist in this environment. Little is known about how S. sapr...
Source: Microbes and Infection - December 5, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: October–November 2019Source: Microbes and Infection, Volume 21, Issues 8–9Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - November 27, 2019 Category: Infectious Diseases Source Type: research
Cholera in the time of likes. Inspirational pathogens and an important pump
Publication date: October–November 2019Source: Microbes and Infection, Volume 21, Issues 8–9Author(s): Sophia Häfner (Source: Microbes and Infection)
Source: Microbes and Infection - November 27, 2019 Category: Infectious Diseases Source Type: research
Enhanced expression of NLRP3 inflammasome components by monocytes of patients with pulmonary paracoccidioidomycosis is associated with smoking and intracellular hypoxemia
Publication date: Available online 23 November 2019Source: Microbes and InfectionAuthor(s): Barbara Casella Amorim, Ana Carla Pereira-Latini, Márjorie de Assis Golim, Raul Lopes Ruiz Júnior, Hugo Hyung Bok Yoo, Maria Sueli Parreira de Arruda, Aldo Henrique Tavares, Ricardo Souza Cavalcante, Rinaldo Poncio Mendes, Alessandra Pontillo, James VenturiniAbstractParacoccidioidomycosis (PCM) is a systemic mycosis caused by thermally dimorphic fungi of the genus Paracoccidioides that affects predominantly 30-60-year-old male rural workers. The main clinical forms of the disease are acute/subacute, chronic (CF); almost all CF pat...
Source: Microbes and Infection - November 24, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: August–September 2019Source: Microbes and Infection, Volume 21, Issue 7Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - November 20, 2019 Category: Infectious Diseases Source Type: research
Editorial board
Publication date: June–July 2019Source: Microbes and Infection, Volume 21, Issues 5–6Author(s): (Source: Microbes and Infection)
Source: Microbes and Infection - November 7, 2019 Category: Infectious Diseases Source Type: research
Metformin promotes Mycobacterium tuberculosis killing and increases the production of human β-defensins in lung epithelial cells and macrophages
Publication date: Available online 2 November 2019Source: Microbes and InfectionAuthor(s): Adrian Rodriguez-Carlos, Claudia Valdez-Miramontes, Paulina Marin-Luevano, Irma González-Curiel, Jose A. Enciso-Moreno, Bruno Rivas-SantiagoAbstractDiabetes has been associated with an increased risk of developing tuberculosis. The reasons related to the increased susceptibility to develop TB in type 2 diabetes mellitus (T2DM) individuals, has not been completely elucidated. However, this susceptibility has been attributed to several factors including failures and misfunctioning of the immune system. In the present study, we aimed t...
Source: Microbes and Infection - November 2, 2019 Category: Infectious Diseases Source Type: research
Anti-tuberculosis (TB) chemotherapy dynamically rescues Th1 and CD8+ T effector levels in Han Chinese pulmonary TB patients
Publication date: Available online 1 November 2019Source: Microbes and InfectionAuthor(s): Guobao Li, Fang Yang, Xing He, Zhi Liu, Jiang Pi, Yuzhen Zhu, Xue Ke, Shuyan Liu, Min Ou, Huixin Guo, Zhuoran Zhang, Gucheng Zeng, Guoliang ZhangAbstractCD4+/CD8+ T cells play a major role in conferring immune protection against tuberculosis (TB), but it remains unknown how the immune responses of CD4+/CD8+ T cells exactly correlate with the clinical variables and disease statuses during anti-TB chemotherapy. To address this, several major immune parameters of CD4+/CD8+ T cells in peripheral blood derived from pulmonary TB patients a...
Source: Microbes and Infection - November 1, 2019 Category: Infectious Diseases Source Type: research
