Comparative sequence, structure and functional analysis of Skp protein, a molecular chaperone among members of Pasteurellaceae and its homologues in Gram-negative bacteria
Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Rajamanikandan Sundarraj, Nihar Nalini Mohanty, Revanaiah Yogisharadhya, Jeyaraman Jeyakanthan, Awadesh Prajapati, Mohammed Mudassar Chanda, Sathish Bhadravati Shivachandra (Source: Meta Gene)
Source: Meta Gene - February 27, 2020 Category: Genetics & Stem Cells Source Type: research
Screening of antibiotic resistance genes and virulence determinants of Staphylococcus aureus from skin infections
Publication date: Available online 26 February 2020Source: Meta GeneAuthor(s): Mustafa Hasan Talha, Saba Saadoon Khazaal, Mayson Khudair Al Hadraawy, Seyyed Khalil Shokouhi Mostafavi (Source: Meta Gene)
Source: Meta Gene - February 26, 2020 Category: Genetics & Stem Cells Source Type: research
Occurrence of +874T/A gene polymorphism of interferon-gamma in Iraqi atopic patients
This study aimed to determine serum total IgE level, eosinophil count, and serum level of IFN-γ, in relation to the age of atopic patients and genotyping of the IFN-γ gene at +874 T/A in relation to serum IFN-γ level. As well as comparing of IFN-γ concentrations of atopic patients according to genotypes in atopic patients and apparently healthy control. The studied groups were 25 apparently healthy controls and 75 atopic patients (25 asthma patients, 25 allergic rhinitis patients and 25 atopic dermatitis patients). The obtained results showed that, the prevalence of atopic diseases occurred in the age group between 2...
Source: Meta Gene - February 23, 2020 Category: Genetics & Stem Cells Source Type: research
Association of urokinase and Vitamin D receptor genes SNPs and urolithiasis in an Iraqi population
ConclusionThere was a significant association between urokinase gene 3’-UTR TT (rs4065) and VDR genes (rs731236) polymorphisms urolithiasis. In addition, VDR CC genotype was significantly associated with recurrent urolithiasis. However, more in-depth verifications will be helpful towards disclosure of genetic mutations predisposing first-time and recurrent urolithiasis. (Source: Meta Gene)
Source: Meta Gene - February 23, 2020 Category: Genetics & Stem Cells Source Type: research
In-silico analysis of deleterious missense SNPs of human TYR gene associated with oculocutaneous albinism type 1 (OCA1)
In this study, we identified ten deleterious missense mutations which may be contributing factors for OCA1. The 3D modeling analysis of mutant models of tyrosinase also strengthen the hypothesis that these mutations may induce significant structural and conformational changes on the native tyrosinase enzyme. (Source: Meta Gene)
Source: Meta Gene - February 21, 2020 Category: Genetics & Stem Cells Source Type: research
Association of Interleukin 6 and insulin resistance gene polymorphism with polycystic ovarian syndrome: A meta-analysis
ConclusionThe results of the meta-analysis were found to be associated with PCOS condition. These genetic predisposition and pre prediction can interpret the chance of getting PCOS condition. (Source: Meta Gene)
Source: Meta Gene - February 21, 2020 Category: Genetics & Stem Cells Source Type: research
Study of metallothionein-2A mRNA relative expression and oxidant status in females with breast cancer
ConclusionsBlood Metallothionein- 2A relative expression and oxidant status may have a prognostic value in breast cancer patients. (Source: Meta Gene)
Source: Meta Gene - February 21, 2020 Category: Genetics & Stem Cells Source Type: research
The association of CNTNAP2 rs2710102 and ENGRAILED-2 rs1861972 genes polymorphism and autism in Iranian population
Publication date: June 2020Source: Meta Gene, Volume 24Author(s): Fatemeh Beiranvandi, Mansoureh Akouchekian, Gholam Reza Javadi, Hossein DarvishAbstractAutism spectrum disorder (ASD) is a highly heritable neurodevelopment disease characterized by impaired social interactions, communication deficits, restricted interests, stereotyped and repetitive behaviors, which results from the interaction between genetic vulnerability and environmental factors. Our study was aimed to explore the association between CNTNAP2 gene polymorphism (rs2710102 C/T) and ENGRAILED-2 (EN2) (rs1861972 A/G) with the risk of autism in the Iranian po...
Source: Meta Gene - February 21, 2020 Category: Genetics & Stem Cells Source Type: research
Analysis of HLA association among North Indian HIV positive individuals with and without tuberculosis
ConclusionA comparative high-resolution analysis of B*35Px or B*35Py alleles among healthy controls and HIV+ individuals showed an overrepresentation of HLA-B*35Px alleles in the healthy Indian gene pool (58%) and in the HIV+ cohort (70%). The most common B*35 subtype found among the HIV infected subjects was B*3503/55 (20%; Px group), followed by B*3501 (10%; Py group). Our study concludes that the Indian gene pool possesses higher frequency of B*35Px alleles. (Source: Meta Gene)
Source: Meta Gene - February 20, 2020 Category: Genetics & Stem Cells Source Type: research
DNA repair gene polymorphism (XPA and XPG) and risk of urinary bladder cancer in North-Indian population
ConclusionXPA and XPG polymorphism might be significant risk factor in North-Indian population and acquisition of these genetic variations together with smoking might trigger urinary bladder cancer development. Further pathway based studies on larger population are warranted to confirm our conclusion.Clinical significanceThe XPA-A23G and XPG-Asp1104His genetic variations could be used as UBC susceptibility markers in North-Indian population. These SNPs could be useful biomarkers for UBC prognosis or diagnosis and thus could help in enhancing the survival rates of UBC patients and improving patient care. However, before mak...
Source: Meta Gene - February 20, 2020 Category: Genetics & Stem Cells Source Type: research
Parental transmission effect of PDGF-C gene variants on non-syndromic cleft lip with or without cleft palate
Publication date: Available online 12 February 2020Source: Meta GeneAuthor(s): Ginila T. Raju, Bhaskar V.K.S. Lakkakula, Jyotsna Murthy, Solomon F.D. PaulAbstractPlatelet derived growth factor -c (PDGF-C) plays a major role in embryogenesis especially during the neural crest cell induction. Animal studies revealed that PDGF signalling is required for orofacial development. Further, Pdgfc knockout mice also showed cleft face phenotype. The present study aims to evaluate the parental transmission effect of PDGF-C gene variants in the etiology of non-syndromic cleft lip with or without cleft palate (NSCL/P) in South Indian po...
Source: Meta Gene - February 13, 2020 Category: Genetics & Stem Cells Source Type: research
Immunomodulation by Acinetobacter baumannii of endotracheal tube biofilm in ventilator-associated pneumonia
Publication date: Available online 13 February 2020Source: Meta GeneAuthor(s): Saba Saadoon Khazaal, Nadal Al-Saryi, Susan A. IbrahimAbstractAcinetobacter baumannii is an opportunistic bacterial pathogen associated with hospital-acquired infections especially in intensive care units (ICU). Main reasons for A. baumannii acquired infections are high ability to acquire antibiotic resistant and biofilm formation. The formation of biofilm that confers persistent to A.baumannii infections and its immunological response are not studied. A.baumannii isolate originated from endotracheal tube of patients admitted to ICU was recovere...
Source: Meta Gene - February 13, 2020 Category: Genetics & Stem Cells Source Type: research
The association of CNTNAP2 rs2710102 and ENGRAILED-2rs1861972 genes polymorphism and autism in Iranian population
Publication date: Available online 11 February 2020Source: Meta GeneAuthor(s): Fatemeh Beiranvandi, Mansoureh Akouchekian, Gholam Reza Javadi, Hossein DarvishAbstractAutism spectrum disorder (ASD) is a highly heritable neurodevelopment disease characterized by impaired social interactions, communication deficits, restricted interests, stereotyped and repetitive behaviors, which results from the interaction between genetic vulnerability and environmental factors. Our study was aimed to explore the association between CNTNAP2 gene polymorphism (rs2710102 C/T) and ENGRAILED-2(EN2) (rs1861972 A/G) with the risk of autism in th...
Source: Meta Gene - February 12, 2020 Category: Genetics & Stem Cells Source Type: research
Deleterious variants in genes associated with bone mineral density are linked to susceptibility to periodontitis development
Publication date: Available online 11 February 2020Source: Meta GeneAuthor(s): Mezzavilla Massimo, Zupin Luisa, Navarra Chiara Ottavia, Di Lenarda Roberto, Gasparini Paolo, Crovella Sergio, Robino Antonietta, Bevilacqua LorenzoAbstractStudies have investigated the relationship between periodontitis and the decrement of the bone mineral density (BMD). However, there is limited knowledge on the possible association between BMD-related genes and susceptibility to periodontitis development.To fill this gap, a total of 157 genes, previously associated with BMD, were analyzed in 442 subjects affected by chronic periodontitis.Can...
Source: Meta Gene - February 12, 2020 Category: Genetics & Stem Cells Source Type: research
Downregulation of microRNA-214 and PTEN in tissue samples of patients with breast cancer
ConclusionThese findings suggest that miR-214 and PTEN have tumor-suppressor activity and thus, pharmaceutical interventions targeting miR-124 and PTEN may provide a promising therapeutic strategy for the treatment of breast cancer. (Source: Meta Gene)
Source: Meta Gene - February 11, 2020 Category: Genetics & Stem Cells Source Type: research
