[Corrections] Corrections
Doty RL. Olfactory dysfunction in neurodegenerative diseases: is there a common pathological substrate. Lancet Neurol 2017; 16: 478 –88—In figure 1, the legend for panel 1B contained additional definitions. These definitions have now been removed and the legend states: “bs=basal cell undergoing mitosis. d=degenerative cell. lp=lamina propria. n=collection of axons within an ensheathing cell.” Referencing errors in the Ai r pollution and smoking section have also been corrected. The corrected sentences now state “Air pollution might be a risk factor for mild cognitive impairment,88 Alzheimer's disease,89,90 and Pa...
Source: Lancet Neurology - June 14, 2017 Category: Neurology Tags: Corrections Source Type: research
[Comment] Gadolinium deposition: practical guidelines in the face of uncertainty
Gadolinium-based contrast agents (GBCAs) are commonly used in MRI examinations to highlight tissues after intravenous injection. These contrast agents have proven indispensable for the diagnosis and monitoring of neurological diseases and are an invaluable research tool for the development of treatments and in the investigation of pathophysiology. For example, in patients with multiple sclerosis, gadolinium-enhancing lesions are a surrogate marker of disease activity and their identification can hasten diagnosis. (Source: Lancet Neurology)
Source: Lancet Neurology - June 14, 2017 Category: Neurology Authors: Kevin H Terashima, Daniel S Reich Tags: Comment Source Type: research
[Comment] Identification of patients at risk for poor outcome after mTBI
The study by Joukje van der Naalt and colleagues1 in The Lancet Neurology aimed to develop a prognostic model for 6-month functional outcome in 679 patients with mild traumatic brain injury (mTBI). In their model, the authors used a multifactorial approach by including sociodemographic, injury-related, and pre-injury factors, as well as indicators of stress after injury and coping strategies. Of the factors measured on admission to the emergency department, lower education, female sex, mental health problems before injury, neck pain, lower Glasgow Coma Scale scores, shorter post-traumatic amnesia, and the absence of alcoho...
Source: Lancet Neurology - June 14, 2017 Category: Neurology Authors: Hester F Lingsma, Maryse C Cnossen Tags: Comment Source Type: research
[Editorial] Integrating palliative care into neurological practice
When initiating end-of-life care discussions, both clinicians and patients often fail to distinguish palliative care from hospice care —palliative treatment which is delivered at the end of life. However, in recent years, palliative care specialists have begun to provide support more frequently in the early stages of disease, alongside disease-directed therapy. For patients with progressive neurological disease, discussing pallia tive care with their physician and family early in the course of their disease might be a crucial factor in their participation in treatment decisions and maintenance of their quality of life. (...
Source: Lancet Neurology - June 14, 2017 Category: Neurology Authors: The Lancet Neurology Tags: Editorial Source Type: research
[Articles] Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis
NfL in plasma shows promise as a potential prognostic blood biomarker of disease onset and progression in Huntington's disease. (Source: Lancet Neurology)
Source: Lancet Neurology - June 7, 2017 Category: Neurology Authors: Lauren M Byrne, Filipe B Rodrigues, Kaj Blennow, Alexandra Durr, Blair R Leavitt, Raymund A C Roos, Rachael I Scahill, Sarah J Tabrizi, Henrik Zetterberg, Douglas Langbehn, Edward J Wild Tags: Articles Source Type: research
