Multipotent Stem Cell and Reproduction.
Authors: Khanlarkhani N, Baazm M, Mohammadzadeh F, Najafi A, Mehdinejadiani S, Sobhani A
Abstract
Stem cells are self-renewing and undifferentiated cell types that can be differentiate into functional cells. Stem cells can be classified into two main types based on their source of origin: Embryonic and Adult stem cells. Stem cells also classified based on the range of differentiation potentials into Totipotent, Pluripotent, Multipotent, and Unipotent. Multipotent stem cells have the ability to differentiate into all cell types within one particular lineage. There are plentiful advantages and usages for mul...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Biodegradable Gelatin Methacrylate Gel as a Potential Scaffold for Bone Tissue Engineering of Canine Adipose-Derived Stem Cells.
Authors: Aparnathi MK, Patel JS
Abstract
Therapeutic potential of adipose derived stem cells (ADSCs) has widely been explored for treatment of orthopedic ailments. Transplantation of cells encapsulated in a scaffold facilitates 3 dimensional modelling of the tissue for the cases where well-defined spatial distribution of cells is desired for implantation. Present study aims to encapsulate canine ADSCs (cADSCs) in biodegradable methacrylated gelatin gel (GelMA) scaffold followed by their osteogenic differentiation for fabrication of a three dimensional bone tissue construct. Different percentages (5, 10 and...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Mandibular Reconstruction in Ameloblastoma Using Allogeneic Cord Stem Cells and Alloplastic Graft Material - Case Report.
Authors: Manimaran K, Chandramohan M, Kannan R, Sankaranarayanan S, Ravi VR, Sharma R
Abstract
Ameloblastoma is a histologically benign odontogenic tumour and has a tendency of locally aggressive behaviour. This is second most prevalent odontogenic tumour and most common in the molar-ramus-angle region and surgical resection is only treatment option. In this article, we propose an innovative approach to deal with these cases by using alloplastic graft with cord stem cells. Over 2.5 years follow-up, we could demonstrate bone regeneration using this technique with no recurrence. To the best of our knowledge,...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Role of STPK in Maintaining the Quiescent Nature of Human CD34(+) Stem Cells.
Authors: Sunitha MM, Srikanth L, Kumar PS, Chandrasekhar C, Sarma PV
Abstract
Haematopoietic stem cell normally exists in the hypoxic niche of bone marrow and in this high anaerobic condition phosphorylation is vital in understanding the stemness of these stem cells in bone marrow. Analysis of human aldehyde dehydrogenase (ALDH) and isocitrate dehydrogenase (IDH) we have observed the presence of serine threonine protein kinase (STPK) sites in the protein sequence of these enzymes conferring that functioning of ALDH and IDH is regulated largely by STPK through phosphorylation. Human CD34(+) stem cells and m...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Treatment of AVN Using Autologous BM Stem Cells and Activated Platelet-Derived Growth Factor Concentrates.
Conclusion: Combination of stem cell and PRP-GFC therapy has shown promising cartilage regeneration in 45 out of 48 patients of AVN. This study clearly demonstrates the safety and efficacy of this treatment. Larger numbers of patients need to be evaluated to better understand the efficacy of the combined stem cell and PRP-GFC therapy on AVN patients.
PMID: 28296878 [PubMed - in process] (Source: Journal of Stem Cells)
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Stage-Specific Regulation of Erythropoiesis and Its Implications in Ex-Vivo RBCs Generation.
Authors: Singh VK, Saini A, Kalsan M, Kumar N, Chandra R
Abstract
Ex vivo erythropoiesis methods are being developed for more than a decade now, and all the distinct types of stem cells (such as CD34(+) HSCs, ESCs, IPSCs, and extensively proliferating erythropoietic progenitor cells) are defined to bear the potential for large scale RBC production shortly. The various regulating factors at different levels of RBCs production are being explored. Since most of the ex-vivo erythropoiesis protocols mimic the dogma followed by hematopoietic stem cells in vivo to give rise to mature RBCs which essentially deals ...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Need for In Vivo Triggering of Homeostasis to Repair Irreversible Tissue Degeneration by Stem Cells through Innate and Invasive Regeneration Processes.
Authors: Navada JS, Koka PS
Abstract
The regeneration patterns are innate, inherited and evolutionarily conserved mechanisms. In every individual there are certain cells and signaling networks which work together to proliferate the desired tissue lineages to replace the dead, lost and injured counter parts. This homeostasis mechanism keeps functioning of the organ system intact. There are some tissues such as skin, gut, blood, respiratory tract, uterine endometrium, testis must perpetually renew the majority of cells. As the aging advances the turnover potentials decreases under normal circumstances, some ...
Source: Journal of Stem Cells - March 18, 2017 Category: Stem Cells Tags: J Stem Cells Source Type: research
Therapeutic Application of Bone Marrow-Derived Stem Cells in a Patient with Methanol-Induced Blindness.
CONCLUSION: Treatment with retrobulbar and intrathecal autologous bone marrow derived stem cell in an adult male patient with bilateral visual loss due to accidental ingestion of methanol was effective. Larger studies are warranted to explore the real impact of this procedure.
PMID: 26665934 [PubMed - in process] (Source: Journal of Stem Cells)
Source: Journal of Stem Cells - December 20, 2015 Category: Stem Cells Tags: J Stem Cells Source Type: research
Hematopoietic Stem Cells, Their Niche, and the Concept of Co-Culture Systems: A Critical Review.
Authors: Vaidya A, Kale V
Abstract
Hematopoietic stem cells (HSCs) have the ability to self-renew and give rise to all lineages of blood cells. HSCs reside in niches that are local tissue microenvironments that maintain and regulate them. Although much progress has been made in elucidating the location and cellular components of the HSC niche, however it still remains incompletely defined. Transplantation using HSCs has been applied for the treatment of several diseases but with limited success. Furthermore, although human HSC transplantation has been widely used to rescue the patients after cytoablative t...
Source: Journal of Stem Cells - December 20, 2015 Category: Stem Cells Tags: J Stem Cells Source Type: research
Age, Sex, and Religious Beliefs Impact the Attitude towards Cord Blood Banking.
In this study, a self-administered questionnaire was used to assess opinions about stem cell research and cord blood banking. Three attitudes were examined: willingness to accept cord blood banking, willingness to accept embryonic stem cell research, and religious belief system. A total of 90 Wayne State University students enrolled in the study in response to an invitation posted on a web page for the university. Sex distribution among study participants was 79 females and eight males; three declined to state their sex. Support for cord blood banking was high (> 70%) among students. Students over the age of 25 years of...
Source: Journal of Stem Cells - December 20, 2015 Category: Stem Cells Tags: J Stem Cells Source Type: research
Mechanism of Induction: Induced Pluripotent Stem Cells (iPSCs).
This article addresses the iPSCs technology mechanisms, progresses and current perspectives in the field.
PMID: 26665937 [PubMed - in process] (Source: Journal of Stem Cells)
Source: Journal of Stem Cells - December 20, 2015 Category: Stem Cells Tags: J Stem Cells Source Type: research
Mesenchymal Stem Cells and Lung Transplantation: A Couple for a Perfect Relationship.
Authors: Mohamed MS
Abstract
With the increased incidence of lung and other organ failure, organ transplantation becomes a frequent surgical intervention. Research is focused on improving the practice of lung and other organ transplantation in order to improve the clinical outcome and to decrease the incidence of post-operative complications. This manuscript represents the author's view of the possibility of improving the lung transplantation outcome through the co-transplantation of mesenchymal stem cells, and the expected positive effects of that application.
PMID: 26665938 [PubMed - in process] ...
Source: Journal of Stem Cells - December 20, 2015 Category: Stem Cells Tags: J Stem Cells Source Type: research
