Endogenous neurosteroids influence synaptic GABAA receptors during postnatal development
GABA plays a key role in both embryonic and neonatal brain development. For example, during early neonatal nervous system maturation, synaptic transmission, mediated by GABAA receptors (GABAARs), undergoes a temporally specific form of synaptic plasticity to accommodate the changing requirements of maturing neural networks. Specifically, the duration of miniature inhibitory postsynaptic currents (mIPSCs), resulting from vesicular GABA activating synaptic GABAARs, is reduced, permitting neurones to appropriately influence the window for postsynaptic excitation. Conventionally, programmed expression changes to the subtype of...
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: D. Belelli, A. R. Brown, S. J. Mitchell, B. G. Gunn, M. B. Herd, G. D. Phillips, M. Seifi, J. D. Swinny, J. J. Lambert Tags: REVIEW ARTICLE Source Type: research
Non ‐neural androgen receptors affect sexual differentiation of brain and behaviour
Although gonadal testosterone is the principal endocrine factor that promotes masculine traits in mammals, the development of a male phenotype requires local production of both androgenic and oestrogenic signals within target tissues. Much of our knowledge concerning androgenic components of testosterone signalling in sexual differentiation comes from studies of androgen receptor (Ar) loss of function mutants. Here, we review these studies of loss of Ar function and of AR overexpression either globally or selectively in the nervous system of mice. Global and neural mutations affect socio‐sexual behaviour and the neuroana...
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: D. A. Monks, A. Swift ‐Gallant Tags: REVIEW ARTICLE Source Type: research
Understanding the role of steroids in typical and atypical brain development: Advantages of using a “brain in a dish” approach
Steroids have an important role in growth, development, sexual differentiation and reproduction. All four classes of steroids, androgens, oestrogens, progestogens and glucocorticoids, have varying effects on the brain. Androgens and oestrogens are involved in the sexual differentiation of the brain, and also influence cognition. Progestogens such as progesterone and its metabolites have been shown to be involved in neuroprotection, although their protective effects are timing‐dependent. Glucocorticoids are linked with stress and memory performance, also in a dose‐ and time‐dependent manner. Importantly, dysfunction i...
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: D. Adhya, E. Annuario, M. A. Lancaster, J. Price, S. Baron ‐Cohen, D. P. Srivastava Tags: REVIEW ARTICLE Source Type: research
Past, present and future of epigenetics in brain sexual differentiation
Sexual differentiation has long been considered “epigenetic”, although the meaning of that word has shifted over time. Here, we track the evolution of ideas about epigenetics in sexual differentiation, and identify principles that have emerged from recent studies. Experiments manipulating a particular epigenetic mechanism during neonatal life demonstrate a role for both histone acetylation and DNA methylation in the development of sex differences in the brain and behaviour of rodents. In addition, hormone‐dependent sex differences in the number of neurones of a particular phenotype may be programmed by differences in...
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: N. G. Forger Tags: REVIEW ARTICLE Source Type: research
New perspectives for the action of steroids in the brain
(Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Authors: G. C. Panzica, R. C. Melcangi Tags: EDITORIAL Source Type: research
Issue Information
(Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 18, 2018 Category: Endocrinology Tags: ISSUE INFORMATION Source Type: research
Activation patterns of vasopressinergic and oxytocinergic brain regions following social play exposure in juvenile male and female rats
Journal of Neuroendocrinology,Volume 0, Issue ja, -Not available-. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 9, 2018 Category: Endocrinology Authors: C. J. Reppucci
,
C. K. Gergely
,
A. H. Veenema Source Type: research
Timing of Prenatal Exposure to Trauma and Altered Placental Expressions of HPA ‐Axis Genes and Genes Driving Neurodevelopment
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 9, 2018 Category: Endocrinology Authors: Wei Zhang, Li Qian, Maya Deyssenroth, Luca Lambertini, Jackie Finik, Jacob Ham, Yongling Huang, Kenji J Tsuchiya, Patricia Pehme, Jessica Buthmann, Sachiko Yoshida, Jia Chen, Yoko Nomura Tags: Original Article Source Type: research
Acute anti ‐obesity effects of intracerebroventricular 11β‐HSD1 inhibitor administration in diet‐induced obese mice
Journal of Neuroendocrinology,Volume 30, Issue 3, March 2018. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 8, 2018 Category: Endocrinology Source Type: research
Neural androgen receptors affect the number of surviving new neurons in the adult dentate gyrus of male mice
This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 7, 2018 Category: Endocrinology Authors: Ashlyn Swift ‐Gallant, Paula Duarte‐Guterman, Dwayne K. Hamson, Muna Ibrahim, D. Ashley Monks, Liisa A. M. Galea Tags: Original Article Source Type: research
Activation of organum vasculosum neurons and water intake in mice by vasopressin neurons in the suprachiasmatic nucleus
Journal of Neuroendocrinology,Volume 0, Issue ja, -Not available-. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 5, 2018 Category: Endocrinology Authors: Claire Gizowski
,
Cristian Zaelzer
,
Charles W. Bourque Source Type: research
A Systematic Review and Quantitative Meta ‐Analysis of Oxytocin's Effects on Feeding
ConclusionsOxytocin reduces energy intake when administered as a single dose. Oxytocin can inhibit feeding over two‐ to three‐week periods in rodent models. These effects typically do not persist beyond the third week of treatment. The anorexigenic effect of oxytocin is moderated by pregnant status, dose, method of administration, and diet composition.This article is protected by copyright. All rights reserved. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - February 1, 2018 Category: Endocrinology Authors: Monica Leslie, Paulo Silva, Yannis Paloyelis, James Blevins, Janet Treasure Tags: Review Article Source Type: research
Neonatal exposure to estradiol increases dopaminergic transmission in Nucleus Accumbens and morphine ‐induced conditioned place preference in adult female rats
Journal of Neuroendocrinology,Volume 0, Issue ja, -Not available-. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - January 29, 2018 Category: Endocrinology Authors: Christian Bonansco
,
Jonathan Mart ínez‐Pinto
,
Roxana A. Silva
,
Victoria B. Velásquez
,
Andrés Martorell
,
Mónica V. Selva
,
Pedro Espinosa
,
Pablo R. Moya
,
Gonzalo Cruz
,
María Estela Andrés
,
Ramón Sotomayor‐Zárate Source Type: research
Metabotropic glutamate receptor subtype 7 has critical roles in regulation of the endocrine system and social behaviours
Journal of Neuroendocrinology,Volume 30, Issue 3, March 2018. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - January 29, 2018 Category: Endocrinology Source Type: research
Maternal thyroid hormone is required for parvalbumin neurone development in the anterior hypothalamic area
Journal of Neuroendocrinology,Volume 30, Issue 3, March 2018. (Source: Journal of Neuroendocrinology)
Source: Journal of Neuroendocrinology - January 29, 2018 Category: Endocrinology Source Type: research
