Centrally-administered AMPA antagonists increase locomotion in parkinsonian rats
SummaryIt was shown in the present study that three antagonists of the α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) glutamate receptor, including 2,3-dihydroxy-6-nitro-7-sulfamoylbenzo(f)quinoxaline (NBQX), 1-(4-aminophenyl)-4-methyl-7,8-methylenedioxy-5H-2,3-benzodiazepine (GYKI 52466) and 6-(1H-imidazol-1-yl)-7-nitro-2,3-(1H,4H)-quinoxalinedione (YM90 K), caused marked reversal of akinesia when administered into the entopeduncular nucleus of rats rendered parkinsonian by bilateral substantia nigra pars compacta lesion. These data suggest that centrally active AMPA antagonists may have therapeutic utility ...
Source: Journal of Neural Transmission - June 1, 1995 Category: Neurology Source Type: research
The use of famotidine in the treatment of Parkinson's disease: a pilot study
SummarySeven patients with idiopathic Parkinson's disease were enrolled in a ten week study to evaluate the efficacy of famotidine, an histamine H2-antagonist, in the treatment of bradyphrenia. Patients received famotidine 80 mg/day for a period of six weeks and were evaluated with neuropsychological tests. Overall, patients demonstrated improvement in variables measured. Some patients also reported an improvement in their motor symptoms. (Source: Journal of Neural Transmission)
Source: Journal of Neural Transmission - June 1, 1995 Category: Neurology Source Type: research
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(Source: Journal of Neural Transmission)
Source: Journal of Neural Transmission - June 1, 1995 Category: Neurology Source Type: research
Erratum
(Source: Journal of Neural Transmission)
Source: Journal of Neural Transmission - June 1, 1995 Category: Neurology Source Type: research
Glutamatergic regulation of striatal peptide gene expression in rats
Summary
The mRNA levels encoding enkephalin and substance P were measured in the rat striatum following cortical ablation, blockade of N-methyl-D-aspartate (NMDA) receptors or inhibition of glutamate release by lamotrigine. Unilateral ablation of the cerebral cortex resulted in a decrease of substance P mRNA levels particularly in the rostral dorsolateral and dorsomedial striatum ipsilateral to the lesion. There was a similar trend for a reduction in levels of enkephalin mRNA. Continuous, intrastriatal infusion of the competitive NMDA receptor antagonist, 3-((±)-2-carboxypiperazin-4-yl)-propyl-1-phosph...
Source: Journal of Neural Transmission - June 1, 1995 Category: Neurology Source Type: research
Neuropsychological characteristics of parkinsonian patients with lateralized motor impairment
SummaryParkinsonians with predominantly unilateral signs provide an interesting experimental means to evaluate if asymmetric nigro-striatal degeneration may affect neuropsychological functions. The aim of our study was to establish if the side of onset of idiopathic Parkinson's disease, right (PDR) or left (PDL), determines a selective pattern of cognitive performances. Furthermore, we verified if PDR and PDL groups show a different frequency of dementia. PDR and PDL patients with at least seven years of disease duration, matched for age, schooling, severity of extrapyramidal symptomatology and index of lateralization, wer...
Source: Journal of Neural Transmission - May 31, 1995 Category: Neurology Source Type: research
