Erlotinib: Lacking of Cholinergic Effects on Tracheal Smooth Muscle
This study demonstrated that erlotinib had no cholinergic effects in vitro, suggesting it may be safe for asthmatic patients with non-small-cell lung cancer after further investigation. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

The Effect of Antibiotic Ointment on Nasal Packings: Is it Effective in Reducing Postoperative Nasal Bacterial Loads?
Publication date: June 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 3 Author(s): Po-Yueh Chen , Kuei Chen , Pin-Zhi Chao , Hsin-Te Hsu , Shih-Han Hung Nasal packing is a widely used procedure in various types of nasal surgery and the management of nasal bleeding. The purpose of this study was to evaluate a simple procedure of applying antibiotic ointment to the surface of the packing during the packing procedure. Six patients who were undergoing septomeatoplasty were enrolled in this study. All patients received postoperative antibiotics by mouth (cephalexin 500 mg 4 times dail...
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Hospital-acquired Urinary Tract Infections in Patients with Diabetes and Urinary Catheterization
Conclusion Unlike having diabetes, having a urinary catheter was a significant risk factor for hospital-acquired UTI (p < 0.001). However, diabetic patients with a urinary catheter had a longer length of hospital stay than those without a urinary catheter. The resistance rate of E. coli to first-generation cephalosporins was higher in diabetic patients with a urinary catheter. Fungal infections, renal insufficiency, and cerebral vascular accident were significantly (p < 0.01) related risk factors for mortality. Candida deaths outnumbered other bacterial infections, and fungal UTI was the most prominent i...
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Effect of Ketamine on the Quality of Anesthesia and Postoperative Analgesia in Epidural Anesthesia
Conclusion Epidural ketamine shortened the start time of surgery by reducing the onset time of block and elevating the maximal block level. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Epigenomics of Alzheimer's Disease
Publication date: June 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 3 Author(s): Ramón Cacabelos , Clara Torrellas , Francisco López-Muñoz Alzheimer's disease (AD) is a polygenic/complex disorder in which genomic, epigenomic, and environmental factors are involved. Epigenetic factors have emerged as important mediators of aging, neurodegeneration, and brain disorders. Epigenomic changes underlying the phenotypic expression of AD, represented by deposits of extracellular Aβ aggregates in senile plaques, intracellular neurofibrillary tangles, neuronal loss, dendritic desarboriza...
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Recurrent Complication of Simple and Superficial Pacemaker Pocket Infection Caused by Staphylococcus lugdunensis
Publication date: August 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 4 Author(s): Weng-Chio Tam , Ho-Shun Cheng , Shao-Jung Li , Ming-Hsiung Hsieh (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

A Patient with Obese Hypoventilation Syndrome with Ventilator-associated Pneumonia: Brain Mapping and Polysomnography Outcomes
Publication date: August 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 4 Author(s): Inampudi Jyothi , Thangavel Mahalingam Vijayakumar , Kammella Ananth Kumar , Rajappan Chandra Satish Kumar , Kaliappan Ilango , Ramkumar Sundaraperumal , Aruna Agrawal , Govind Prasad Dubey (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Risk Factors of Carbapenem-resistant Acinetobacter baumannii Infection among Hospitalized Patients
Conclusion This study confirms that prior use of antimicrobials such as piperacillin/tazobactam and amikacin can significantly increase CRAB and CSAB infections in hospitalized patients. The prior use of meropenem increased CRAB infections, but not CSAB infections, in patients who were hospitalized 3 months after the drug exposure. Diabetes and ventilator use were also associated with a high rate of CRAB and CSAB infections. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

The Outcome of Clinical Pharmacists' Interventions in a Taiwanese Hospital on Pharmacoeconomics and Cost Saving
Conclusion Interventions provided by hospital clinical pharmacists significantly prevented potential ADEs by monitor actively drug therapy and patient safety at the intensive care unit, cardiology, neurology, and nephrology care units. To the best of our knowledge, this is the first study to document the potential cost saving and obtained a benefit:cost ratio of 8.4:1 based on the implementation of a proper medication management and use provided by five clinical pharmacists for 6 months in a Taiwan hospital. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Protective Effect of Diindolylmethane against N-Butyl-N-(4-hydroxybutyl) Nitrosamine-induced Bladder Carcinogenesis
Conclusion The results of this study show that DIM inhibited hyperplasia, a condition that reflects the development of initiation of carcinogenesis in an experimental model of nitrosamine-induced bladder carcinogenesis, and this effect of DIM can be attributed to its antioxidant activity and its ability to modulate xenobiotic enzymes. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Factors Associated with Infant Mortality in Malawi
Conclusion The present study shows that improving the quality of life in rural areas, evenly distributing health care delivery services and other social economic factors across the nation, and improving maternal health care, neonatal care, and nutrient intake could decrease infant mortality in Malawi. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Application of Synovial Fluid Mesenchymal Stem Cells: Platelet-rich Plasma Hydrogel for Focal Cartilage Defect
Conclusion The SFMSCs with PRP and thermosensitive hydrogel have a great capability for chondrocyte regeneration and maturation. (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

A Bibliometric Study on Second-generation Antipsychotic Drugs in the Asia–Pacific Region
Publication date: August 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 4 Author(s): Francisco López-Muñoz , Winston W. Shen , Naotaka Shinfuku , Chi-Un Pae , David J. Castle , Albert K. Chung , Kang Sim , Cecilio Álamo In this review, we analyzed the status and changes in the research on second-generation (atypical) antipsychotic drugs in the Asia–Pacific region (i.e., Japan, South Korea, Taiwan, Hong Kong, Singapore, and Australia). We also performed a bibliometric study of the literature in this region on atypical antipsychotic drugs (e.g., clozapine, risperidone, olanz...
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Fatal Varicella Infections in a Young Patient with Systemic Lupus Erythematosus
Publication date: October 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 5 Author(s): Fu-Lun Chen , Tai-Chin Hsieh , Tsong-Yih Ou , Ying-Hua Shieh , Wen-Sen Lee (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research

Necrotizing Fasciitis Caused by Infection with Streptococcus pyogenes Harboring emm Genotype 11 and Sequence Type 403
Publication date: October 2014 Source:Journal of Experimental & Clinical Medicine, Volume 6, Issue 5 Author(s): Akiyoshi Shibayama , Mitsugu Tamaki , Haruyuki Nagasawa , Susumu Nakamata , Yoshitaka Nakamori , Haruno Yoshida , Takashi Takahashi (Source: Journal of Experimental and Clinical Medicine)
Source: Journal of Experimental and Clinical Medicine - November 3, 2014 Category: Journals (General) Source Type: research