The Family of Chloride Channel Regulator, Calcium-activated Proteins in the Feline Respiratory Tract: A Comparative Perspective on Airway Diseases in Man and Animal Models
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): N.A. Erickson, A.D. Gruber, L. MundhenkSummaryMembers of the chloride channel regulator, calcium-activated (CLCA) family are considered to be modifiers in inflammatory, mucus-based respiratory conditions such as asthma and cystic fibrosis. Previous work has shown substantial differences between human and murine CLCA orthologues that limit the value of mouse models. As an alternative, the cat is an unfamiliar but powerful model of human asthma. We therefore characterized the expression profiles of CLCA proteins in the feline respira...
Source: Journal of Comparative Pathology - November 30, 2019 Category: Pathology Source Type: research
Meningeal Granular Cell Tumour in a Green Tree Python (Morelia viridis)
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): D.K. Finnegan, A.N. Cartoceti, A.M. Hauck, E.E.B. LaDouceurSummaryGranular cell tumours (GCTs) are uncommon neoplasms mostly reported in man, dogs and horses. The origin of GCT is thought to be Schwann cells, with the associated characteristics of neural crest morphology. Neoplastic cells often demonstrate positive immunoreactivity for S100, LC3, vimentin and p62. They are also periodic acid–Schiff (PAS) positive and diastase resistant. A female green tree python (Morelia viridis) was presented for severe constipation and hyporex...
Source: Journal of Comparative Pathology - November 30, 2019 Category: Pathology Source Type: research
The Journal of Comparative Pathology Educational Trust 2019 Awards
Publication date: Available online 28 November 2019Source: Journal of Comparative PathologyAuthor(s): M.J. Day (Source: Journal of Comparative Pathology)
Source: Journal of Comparative Pathology - November 29, 2019 Category: Pathology Source Type: research
Dysregulated Expression of Phosphorylated Epidermal Growth Factor Receptor and Phosphatase and Tensin Homologue in Canine Cutaneous Papillomas and Squamous Cell Carcinomas
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): B.L. Sanz Ressel, A.R. Massone, C.G. BarbeitoSummaryThe molecular mechanisms contributing to the development of cutaneous papillomas (CPs) and cutaneous squamous cell carcinomas (CSCCs) are still poorly understood, limiting the ability to identify molecular suitable targets for the development of novel therapies. Persistent activation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) signalling pathway is a component of epidermal carcinogenesis in dogs. The present study describes the immunohist...
Source: Journal of Comparative Pathology - November 27, 2019 Category: Pathology Source Type: research
Pathological Features of Complete Atrioventricular Block in Dogs with Lymphocytic Myocarditis
Publication date: January 2020Source: Journal of Comparative Pathology, Volume 174Author(s): T. Sasaki, C. Saeki, A. Hirakawa, N. MachidaSummaryThe cardiac conduction system was examined histologically in 12 canine cases of lymphocytic myocarditis with complete atrioventricular (AV) block. Histological analysis showed active myocarditis characterized by intense infiltration of mononuclear cells, primarily lymphoid, associated with degeneration and necrosis of the adjacent cardiomyocytes. Additionally, there was healing or healed myocarditis manifested by disappearance of cardiomyocytes and replacement fibrosis. This destru...
Source: Journal of Comparative Pathology - November 27, 2019 Category: Pathology Source Type: research
