Metabolic Dysfunction, Obesity, and Survival Among Patients With Early-Stage Colorectal Cancer [Epidemiology]
Conclusion
Patients with early-stage CRC with obesity and MetSyn have worse survival, overall and CRC related. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Cespedes Feliciano, Kroenke, Meyerhardt, Prado, Bradshaw, Dannenberg, Kwan, Xiao, Quesenberry, Weltzien, Castillo, Caan Tags: Behavioral and Lifestyle Risk Factors, Population and observational studies (SEER, WHI observational, etc.), Epidemiology Source Type: research
Body Mass Index and Metastatic Renal Cell Carcinoma: Clinical and Biological Correlations [Urologic Oncology]
Conclusion
High BMI is a prognostic factor for improved survival and progression-free survival in patients with metastatic RCC treated with targeted therapy. Underlying biology suggests a role for the FASN pathway. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Albiges, Hakimi, Xie, McKay, Simantov, Lin, Lee, Rini, Srinivas, Bjarnason, Ernst, Wood, Vaishamayan, Rha, Agarwal, Yuasa, Pal, Bamias, Zabor, Skanderup, Furberg, Fay, de Velasco, Preston, Wilson, Cho, McDermott, Signoretti, Heng, Choueiri Tags: Behavioral and Lifestyle Risk Factors, Chemotherapy, Epidemiology, Translational Oncology, Genitourinary Urologic Oncology Source Type: research
Contemporary Update of a Multi-Institutional Predictive Nomogram for Salvage Radiotherapy After Radical Prostatectomy [Urologic Oncology]
Conclusion
Early SRT at low PSA levels after RP is associated with improved FFBF and DM rates. Contemporary nomograms can estimate individual patient outcomes after SRT in the modern era. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Tendulkar, Agrawal, Gao, Efstathiou, Pisansky, Michalski, Koontz, Hamstra, Feng, Liauw, Abramowitz, Pollack, Anscher, Moghanaki, Den, Stephans, Zietman, Lee, Kattan, Stephenson Tags: Surgery, Radiation, Combined Modality Therapy, Combined Modality Therapy Urologic Oncology Source Type: research
The BATTLE-2 Study: A Biomarker-Integrated Targeted Therapy Study in Previously Treated Patients With Advanced Non-Small-Cell Lung Cancer [Thoracic Oncology]
Conclusion
Despite improved progression-free survival on therapy that did not contain erlotinib for KRAS mut+ patients and improved prognosis for mesenchymal tumors, better biomarker-driven treatment strategies are still needed. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Papadimitrakopoulou, Lee, Wistuba, Tsao, Fossella, Kalhor, Gupta, Byers, Izzo, Gettinger, Goldberg, Tang, Miller, Skoulidis, Gibbons, Shen, Wei, Diao, Peng, Wang, Tam, Coombes, Koo, Mauro, Rubin, Heymach, Hong, Herbst Tags: Translational Oncology, Chemotherapy, Lung Thoracic Oncology Source Type: research
Baseline Metabolic Tumor Volume Predicts Outcome in High-Tumor-Burden Follicular Lymphoma: A Pooled Analysis of Three Multicenter Studies [Hematologic Malignancy]
Conclusion
Baseline TMTV is a strong independent predictor of outcome in FL. In combination with FLIPI2 score, it identifies patients at high risk of early progression. It warrants further validation as a biomarker for development of first-line PET-adapted approaches in FL. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Meignan, Cottereau, Versari, Chartier, Dupuis, Boussetta, Grassi, Casasnovas, Haioun, Tilly, Tarantino, Dubreuil, Federico, Salles, Luminari, Trotman Tags: Diagnosis & Staging, Nuclear Medicine Hematologic Malignancy Source Type: research
Updated Outcomes and Impact of Age With Lenalidomide and Low-Dose Dexamethasone or Melphalan, Prednisone, and Thalidomide in the Randomized, Phase III FIRST Trial [Rapid Communication]
Conclusion
Results support Rd continuous treatment as a new standard of care for stem-cell transplantation–ineligible patients with newly diagnosed MM of all ages. (Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Hulin, Belch, Shustik, Petrucci, Duhrsen, Lu, Song, Rodon, Pegourie, Garderet, Hunter, Azais, Eek, Gisslinger, Macro, Dakhil, Goncalves, LeBlanc, Romeril, Royer, Doyen, Leleu, Offner, Leupin, Houck, Chen, Ervin-Haynes, Dimopoulos, Facon Tags: Chemotherapy, Biology & Immunology, Rapid Communications Source Type: research
Challenge of Prognostic Uncertainty in the Modern Era of Cancer Therapeutics [COMMENTS AND CONTROVERSIES]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Temel, Shaw, Greer Tags: Quality of Care, End of Life, Supportive Care COMMENTS AND CONTROVERSIES Source Type: research
Optimizing Treatment for Elderly Patients With Newly Diagnosed Multiple Myeloma: A Personalized Approach [ONCOLOGY GRAND ROUNDS]
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice.
An 84-year-old woman presented with bone pain and lytic bone lesions in April 2010. Diagnosis of multiple...
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Larocca, Palumbo Tags: Oncology Grand Rounds Source Type: research
Value of Extra-Early Initiation of Salvage Radiation for Increasing Prostate-Specific Antigen After Prostatectomy [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Nguyen Tags: Radiation EDITORIALS Source Type: research
Can We Define and Reach Precise Goals for Precision Medicine in Cancer Care? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: West Tags: EDITORIALS Source Type: research
Metabolic Tumor Volume in Lymphoma: Hype or Hope? [EDITORIALS]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Schoder, Moskowitz Tags: EDITORIALS Source Type: research
In the Pursuit of Excellence: Reflections From the Editor-in-Chief of Journal of Clinical Oncology [FROM THE EDITOR'S DESK]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Authors: Cannistra Tags: From the Editor's Desk, Notes from the Editors Source Type: research
Advertising [ONCOLOGY CAREER CENTER]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 11, 2016 Category: Cancer & Oncology Tags: ONCOLOGY CAREER CENTER Source Type: research
Erratum [erratum]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 4, 2016 Category: Cancer & Oncology Tags: ERRATUM Source Type: research
Accuracy of Prostate-Specific Antigen Values in Prostate Cancer Registries [CORRESPONDENCE]
(Source: Journal of Clinical Oncology)
Source: Journal of Clinical Oncology - October 4, 2016 Category: Cancer & Oncology Authors: Mittakanti, Thomas, Shelton, Makarov, Skolarus, Cooperberg, Chung, Sonn, Brooks, Leppert Tags: CORRESPONDENCE Source Type: research
