When Translational Neuroscience Fails in the Clinic: Dexamethasone Prior to Virtual Reality Exposure Therapy Increases Drop-Out Rates
Publication date: Available online 29 October 2018Source: Journal of Anxiety DisordersAuthor(s): Jessica Maples-Keller, Tanja Jovanovic, Boadie W. Dunlop, Sheila Rauch, Carly Yasinski, Vasiliki Michopoulos, Callan Coghlan, Seth Norrholm, Albert Skip Rizzo, Kerry Ressler, Barbara O. RothbaumAbstractPosttraumatic stress disorder (PTSD) is characterized by exaggerated expression of fear responses to danger and safety cues. Translational research suggests that dexamethasone facilitates fear extinction in animal and human fear conditioning models. For this randomized, placebo-controlled trial (N = 27), we aimed to translate...
Source: Journal of Anxiety Disorders - October 30, 2018 Category: Psychiatry Source Type: research
PTSD Symptoms are Differentially Associated with General Distress and Physiological Arousal: Implications for the Conceptualization and Measurement of PTSD
ConclusionsResults offer support, with caveats, for viewing PTSD as a distress disorder. Findings are not consistent with the position that PTSD is a hybrid disorder with some features reflecting hyperarousal and others indicative of general distress. Results have implications for the conceptualization and measurement of PTSD. (Source: Journal of Anxiety Disorders)
Source: Journal of Anxiety Disorders - October 30, 2018 Category: Psychiatry Source Type: research
Cognitive-behavior therapy for children and adolescents with anxiety disorders: A meta-analysis of secondary outcomes
Publication date: Available online 30 October 2018Source: Journal of Anxiety DisordersAuthor(s): L.J. Kreuze, G.H.M. Pijnenborg, Y.B. de Jonge, M.H. NautaAbstractAnxiety-focused cognitive-behavioral therapy (CBT) effectively reduces anxiety in children and adolescents. An important remaining question is to what extent anxiety-focused CBT also affects broader outcome domains. Additionally, it remains unclear whether parental involvement in treatment may have impact on domains other than anxiety. A meta-analysis (nstudies = 42, nparticipants = 3239) of the effects of CBT and the moderating role of parental involvemen...
Source: Journal of Anxiety Disorders - October 30, 2018 Category: Psychiatry Source Type: research
Ensemble machine learning prediction of posttraumatic stress disorder screening status after emergency room hospitalization
Publication date: Available online 30 October 2018Source: Journal of Anxiety DisordersAuthor(s): Santiago Papini, Derek Pisner, Jason Shumake, Mark B. Powers, Christopher G. Beevers, Evan E. Rainey, Jasper A.J. Smits, Ann Marie WarrenAbstractPosttraumatic stress disorder (PTSD) develops in a substantial minority of emergency room admits. Inexpensive and accurate person-level assessment of PTSD risk after trauma exposure is a critical precursor to large-scale deployment of early interventions that may reduce individual suffering and societal costs. Toward this aim, we applied ensemble machine learning to predict PTSD screen...
Source: Journal of Anxiety Disorders - October 30, 2018 Category: Psychiatry Source Type: research
The efficacy of cognitive behavior therapy for the treatment of perinatal anxiety symptoms: A preliminary meta-analysis
Publication date: Available online 15 October 2018Source: Journal of Anxiety DisordersAuthor(s): Peta N. Maguire, Gavin I. Clark, Bethany M. WoottonAbstractCognitive-behavior therapy (CBT) is considered the psychological treatment of choice for anxiety disorders in the general population. However the efficacy of CBT for anxiety that occurs during the perinatal period, defined as the period from conception to 12 months post birth, is less understood. Perinatal anxiety is a complex and multifaceted problem that can affect both the pregnant women and the unborn child, as well as the wider family unit. The aim of this study wa...
Source: Journal of Anxiety Disorders - October 16, 2018 Category: Psychiatry Source Type: research
