Multi‐modal CT in acute stroke: wait for a serum creatinine before giving intravenous contrast? No!
ConclusionsThe incidence of CIN is low when MMCT is used routinely to assess acute stroke patients. In this population, CIN was a biochemical phenomenon that did not have clinical manifestations, cause chronic kidney disease, require dialysis, or negatively impact on 90‐day mRS outcomes. Renal profiling and waiting for a baseline serum‐creatinine are an unnecessary delay to emergency reperfusion treatment. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Timothy E. Ang, Andrew Bivard, Christopher Levi, Henry Ma, Chung Y. Hsu, Bruce Campbell, Geoffrey Donnan, Stephen M. Davis, Mark Parsons Tags: Research Source Type: research
One‐year case fatality rate following stroke in the Mashhad Stroke Incidence Study: a population‐based study of stroke in Iran
ConclusionDespite the younger age of stroke occurrence in Iran, the one‐year case fatality rate following stroke is similar to that reported in developed countries. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Ali Shoeibi, Maryam Salehi, Amanda G. Thrift, Moira K. Kapral, Mohammad Taghi Farzadfard, Amir Azarpazhooh, Parvaneh Layegh, Peyman Hashemi, Amin Amiri, Naghmeh Mokhber, Bahare Hassankhani, Mahmoud Reza Azarpazhooh Tags: Research Source Type: research
Heart rate and ischemic stroke: the REasons for Geographic And Racial Differences in Stroke (REGARDS) study
ConclusionIn REGARDS, high resting heart rates were associated with an increased risk of ischemic stroke compared with low heart rates. Further research is needed to examine whether interventions aimed to reduce heart rate decrease stroke risk. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Wesley T. O'Neal, Waqas T. Qureshi, Suzanne E. Judd, James F. Meschia, Virginia J. Howard, George Howard, Elsayed Z. Soliman Tags: Research Source Type: research
Statin use in spontaneous intracerebral hemorrhage: a systematic review and meta‐analysis
ConclusionsAlthough careful interpretation is necessary due to several study limitations, we have demonstrated that statin use in patients with intracerebral hemorrhage is likely associated with improved mortality and functional outcomes. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Jin‐Man Jung, Jeong‐Yoon Choi, Hyun Jung Kim, Woo‐Keun Seo Tags: Systematic Review Source Type: research
Which stroke patients gain most from intermittent pneumatic compression: further analyses of the CLOTS 3 trial
ConclusionsIPC appears to reduce the risk of DVT and probably improves survival in all immobile stroke patients, other than the fifth with the best prognosis. It therefore seems reasonable to recommend that IPC should be considered in all immobile stroke patients, but that the final decision should be based on a judgment about the individual's prognosis. In some, their prognosis for survival with an acceptable quality of life will be so poor that use of IPC might be considered futile, while at the other end of the spectrum, patients' risk of DVT, and of dying from VTE, may not be high enough to justify the modest cost and ...
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Martin Dennis, Catriona Graham, Joel Smith, John Forbes, Peter Sandercock, Tags: Research Source Type: research
Intravenous thrombolysis and intra‐arterial interventions in acute ischemic stroke: Italian Stroke Organisation (ISO)‐SPREAD guidelines
(Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Danilo Toni, Salvatore Mangiafico, Elio Agostoni, Mauro Bergui, Paolo Cerrato, Alfonso Ciccone, Stefano Vallone, Andrea Zini, Domenico Inzitari Tags: Guidelines Source Type: research
Life‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena Hänninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research
High rate of microbleed formation following primary intracerebral hemorrhage
ConclusionsWe found that one‐third of intracerebral hemorrhage subjects in this cohort surviving one‐year developed new microbleeds, which suggests a dynamic and rapidly progressive vasculopathy. Future studies are needed to examine the impact of new microbleed formation on patient outcomes. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Jason Mackey, Jeffrey J. Wing, Gina Norato, Ian Sobotka, Ravi S. Menon, Richard E. Burgess, M. Chris Gibbons, Nawar M. Shara, Stephen Fernandez, Annapurni Jayam‐Trouth, Laura Russell, Dorothy F. Edwards, Chelsea S. Kidwell Tags: Research Source Type: research
Acute Stroke or Transient Ischemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes (SOCRATES) trial: rationale and design
DiscussionThe SOCRATES trial fulfills an important clinical need by evaluating a potent antiplatelet agent as a superior alternative to current standard of care in patients presenting acutely with ischemic stroke or transient ischemic attack. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: S. Claiborne Johnston, Pierre Amarenco, Gregory W. Albers, Hans Denison, J. Donald Easton, Peter Held, Jenny Jonasson, Kazuo Minematsu, Carlos A. Molina, Lawrence K. S. Wong Tags: Protocol Source Type: research
APOE/TOMM40 genetic loci, white matter hyperintensities, and cerebral microbleeds
ConclusionsLack of association between two Alzheimer's disease susceptibility gene loci and markers of cerebral small vessel disease may reflect the relative health of this population compared with those in other studies in the literature. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Donald M. Lyall, Susana Muñoz Maniega, Sarah E. Harris, Mark E. Bastin, Catherine Murray, Michael W. Lutz, Ann M. Saunders, Allen D. Roses, Maria del C. Valdés Hernández, Natalie A. Royle, John M. Starr, David J. Porteous, Ian J. Deary, Joanna M. Wardl Tags: Research Source Type: research
A systematic review and meta‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
ConclusionsThere is clear evidence for improvement in functional independence with endovascular thrombectomy compared with standard medical care, suggesting that endovascular thrombectomy should be considered the standard effective treatment alongside thombolysis in eligible patients. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Joyce S. Balami, Brad A. Sutherland, Laurel D. Edmunds, Iris Q. Grunwald, Ain A. Neuhaus, Gina Hadley, Hasneen Karbalai, Kneale A. Metcalf, Gabriele C. DeLuca, Alastair M. Buchan Tags: Review Source Type: research
Posterior vs. anterior circulation infarction: demography, outcomes, and frequency of hemorrhage after thrombolysis
ConclusionsOur study suggests that posterior circulation stroke is associated with a lower risk of intracranial hemorrhage than anterior circulation stroke is. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 26, 2015 Category: Neurology Authors: Tomáš Dorňák, Michal Král, Martin Hazlinger, Roman Herzig, Tomáš Veverka, Stanislav Buřval, Daniel Šaňák, Jana Zapletalová, Kristýna Antalíková, Petr Kaňovský Tags: Research Source Type: research
Life ‐threatening coronary disease is prevalent in patients with stenosing carotid artery disease
ConclusionsEndarterectomized carotid patients have a high risk of acute myocardial infarction and death, and need an intensified cardiovascular disease‐risk‐lowering treatment. Although asymptomatic, the evaluation of prognostically significant myocardial ischemia should be considered in these high‐risk patients. Eventually, a clinical trial is needed to address whether carotid patients would benefit from early intervention. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Krista Nuotio, Lauri Soinne, Helena H änninen, Jani Saksi, Jarno Tuimala, Antti Jula, Petri T. Kovanen, Markku Kaste, Petra Ijäs, Perttu J. Lindsberg Tags: Research Source Type: research
Novel TIA biomarkers identified by mass spectrometry ‐based proteomics
ConclusionsUtilizing mass spectrometry‐based proteomics, platelet basic protein has been identified as a candidate serum biomarker for transient ischemic attack. This unbiased proteomic approach may be a promising method to identify novel biomarkers to more precisely diagnose transient ischemic attacks. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Paul M. George, Michael Mlynash, Christopher M. Adams, Calvin J. Kuo, Gregory W. Albers, Jean ‐Marc Olivot Tags: Research Source Type: research
A systematic review and meta ‐analysis of randomized controlled trials of endovascular thrombectomy compared with best medical treatment for acute ischemic stroke
ConclusionsThere is clear evidence for improvement in functional independence with endovascular thrombectomy compared with standard medical care, suggesting that endovascular thrombectomy should be considered the standard effective treatment alongside thombolysis in eligible patients. (Source: International Journal of Stroke)
Source: International Journal of Stroke - August 25, 2015 Category: Neurology Authors: Joyce S. Balami, Brad A. Sutherland, Laurel D. Edmunds, Iris Q. Grunwald, Ain A. Neuhaus, Gina Hadley, Hasneen Karbalai, Kneale A. Metcalf, Gabriele C. DeLuca, Alastair M. Buchan Tags: Review Source Type: research
