An audit of the management of childhood-onset growth hormone deficiency during young adulthood in Scotland
Adolescents with childhood onset growth hormone deficiency (CO-GHD) require re-evaluation of their growth hormone (GH) axis on attainment of final height to determine eligibility for adult GH therapy (rhGH). (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - March 16, 2016 Category: Endocrinology Authors: M. Ahmid, V. Fisher, A. J. Graveling, S. McGeoch, E. McNeil, J. Roach, J. S. Bevan, L. Bath, M. Donaldson, G. Leese, A. Mason, C. G. Perry, N. N. Zammitt, S. F. Ahmed and M. G. Shaikh Source Type: research

Efficacy of growth hormone replacement on anthropometric outcomes, obesity, and lipids in children with optic nerve hypoplasia and growth hormone deficiency
Hypopituitarism and obesity are causes of major lifelong morbidity in patients with optic nerve hypoplasia (ONH). Growth hormone deficiency (GHD) affects the majority of children with ONH, though the degree of... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - March 2, 2016 Category: Endocrinology Authors: Carly Stewart, Pamela Garcia-Filion, Cassandra Fink, Anna Ryabets-Lienhard, Mitchell E. Geffner and Mark Borchert Source Type: research

International Journal of Pediatric Endocrinology reviewer acknowledgement 2015
The editor of International Journal of Pediatric Endocrinology would like to thank all of the reviewers who have contributed to the journal in 2015. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - February 24, 2016 Category: Endocrinology Authors: Surendra Varma Source Type: research

Increasing incidence of premature thelarche in the Central Region of Denmark - Challenges in differentiating girls less than 7 years of age with premature thelarche from girls with precocious puberty in real-life practice
Premature thelarche (PT) seems to be increasing and it is difficult to differentiate its early stages from precocious puberty (PP). Clinical and biochemical parameters are warranted to differentiate the two di... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - February 22, 2016 Category: Endocrinology Authors: Mia Elbek Sømod, Esben Thyssen Vestergaard, Kurt Kristensen and Niels Holtum Birkebæk Source Type: research

Etiological and clinical characteristics of central diabetes insipidus in children: a single center experience
Central diabetes insipidus (CDI) results from a number of conditions affecting the hypothalamic-neurohypophyseal system to cause vasopressin deficiency. Diagnosis of CDI is challenging, and clinical data and g... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - February 11, 2016 Category: Endocrinology Authors: Janel D. Hunter and Ali S. Calikoglu Source Type: research

Type 1 diabetes through two lenses: comparing adolescent and parental perspectives with photovoice
Parental support and care-coordination are vital for youth with type 1 diabetes (T1D) in achieving positive health outcomes. Yet, studies are rarely designed to identify factors that influence parent/youth col... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - January 20, 2016 Category: Endocrinology Authors: Ashby Walker, Desmond Schatz, Cathryn Johnson, Janet Silverstein, Shannon Lyles and Henry Rohrs Source Type: research

Type 1 diabetes through two lenses: comparing adolescent and parental perspectives with photovoice
Conclusions: Food-related issues and varying views on supplies may trigger diabetes-specific conflicts. Contrasting viewpoints about the most cumbersome aspects of diabetes may provide insight into differential paths for interventions aimed at offsetting the burdens of T1D for adolescents and parents. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - January 20, 2016 Category: Endocrinology Authors: Ashby WalkerDesmond SchatzCathryn JohnsonJanet SilversteinShannon LylesHenry Rohrs Source Type: research

Pediatric thyroid surgery and management of thyroid nodules – an institutional experience over a 10-year period
We reviewed our institutional experience in the diagnosis and management of pediatric thyroid nodules and well-differentiated thyroid carcinoma (WDTC), highlighting the unique challenges in this population. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - January 13, 2016 Category: Endocrinology Authors: Wen Jiang, Robert O. Newbury and Ron S. Newfield Source Type: research

Pediatric thyroid surgery and management of thyroid nodules – an institutional experience over a 10-year period
Conclusions: In recent years, we are managing significantly more WDTC cases at our institution with advanced disease at the onset. Malignancy rate on indeterminate cytology is higher than reported in adults with an overall high rate of malignancy in thyroid nodules removed in this cohort. Disease control and short-term outcome is still excellent. The recently published pediatric guidelines for WDTC will further standardize management. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - January 13, 2016 Category: Endocrinology Authors: Wen JiangRobert NewburyRon Newfield Source Type: research

Peak cortisol response to corticotropin-releasing hormone is associated with age and body size in children referred for clinical testing: a retrospective review
Corticotropin-Releasing Hormone (CRH) testing is used to evaluate suspected adrenocorticotropic hormone (ACTH) deficiency, but the clinical characteristics that affect response in young children are incomplete... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - October 22, 2015 Category: Endocrinology Authors: Mary Ellen Vajravelu, Jared Tobolski, Evanette Burrows, Marianne Chilutti, Rui Xiao, Vaneeta Bamba, Steven Willi, Andrew Palladino, Jon M. Burnham and Shana E. McCormack Source Type: research

Psychosexual development and quality of life outcomes in females with congenital adrenal hyperplasia
Outcome information regarding females with classical congenital adrenal hyperplasia (CAH) have generally suggested poor quality of life (QoL), general maladjustment, problems regarding sexuality, and decreased... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - October 15, 2015 Category: Endocrinology Authors: Mansi Kanhere, John Fuqua, Richard Rink, Christopher Houk, David Mauger and Peter A. Lee Source Type: research

Psychosexual development and quality of life outcomes in females with congenital adrenal hyperplasia
Conclusion: The data reported here suggest that overall outcome can be very good for females with CAH and that good outcome appears to relate to quality of care and positive social support. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - October 15, 2015 Category: Endocrinology Authors: Mansi KanhereJohn FuquaRichard RinkChristopher HoukDavid MaugerPeter Lee Source Type: research

Focal form of congenital hyperinsulinism clearly detectable by contrast-enhanced computed tomography imaging
The focal form of congenital hyperinsulinism (CHI) is characterized by a cluster of abnormal insulin-oversecreting β cells within a restricted area of the pancreas. Although identification of the focal lesion ... (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - September 15, 2015 Category: Endocrinology Authors: Yukiko Hashimoto, Azumi Sakakibara, Rie Kawakita, Yuki Hosokawa, Rika Fujimaru, Tetsuro Nakamura, Hiroko Fukushima, Aiko Igarashi, Michiya Masue, Hironori Nishibori, Nobuyoshi Tamagawa, Akiko Murakami, Kazue Hatake and Tohru Yorifuji Source Type: research

Focal form of congenital hyperinsulinism clearly detectable by contrast-enhanced computed tomography imaging
In this report, however, we present a case of a 7-month-old girl with the focal form of CHI, caused by a loss-of-function mutation in the ABCC8 gene, whose lesion was clearly visible as a hyperenhancing nodule on contrast-enhanced CT and dynamic MRI imaging. (Source: International Journal of Pediatric Endocrinology)
Source: International Journal of Pediatric Endocrinology - September 15, 2015 Category: Endocrinology Authors: Yukiko HashimotoAzumi SakakibaraRie KawakitaYuki HosokawaRika FujimaruTetsuro NakamuraHiroko FukushimaAiko IgarashiMichiya MasueHironori NishiboriNobuyoshi TamagawaAkiko MurakamiKazue HatakeTohru Yorifuji Source Type: research

Noonan syndrome and Turner syndrome patients respond similarly to 4 years’ growth-hormone therapy: longitudinal analysis of growth-hormone-naïve patients enrolled in the NordiNet® International Outcome Study and the ANSWER Program
Background: Turner syndrome (TS) and Noonan syndrome (NS) are distinct syndromes associated with short stature and other similar phenotypic features. We compared the responses to growth hormone (GH) therapy of TS and NS patients enrolled in the NordiNet® International Outcome Study (IOS) or the American Norditropin Studies: Web-Enabled Research (ANSWER) Program, which collect information on GH therapy in clinical practice. Methods: Repeated-measures regression analysis was performed on change in height standard deviation score (HSDS) and target-height-corrected HSDS, based on national normal references and treatment-naïv...
Source: International Journal of Pediatric Endocrinology - September 8, 2015 Category: Endocrinology Authors: Peter LeeJudith RossBirgitte PedersenPrimoz KotnikJohn GermakHenrik Christesen Source Type: research