Evaluation of C677T polymorphism of the methylenetetra hydrofolate reductase gene and its association with levels of serum homocysteine, folate, and vitamin B12 as maternal risk factors for Down syndrome
Conclusion: Serum levels of folate were low in cases. The RBC folate levels were comparable in both groups. However the combined serum folate and RBC folate were low in cases compared to control groups. Homocysteine levels in our study were higher in Down syndrome mothers compared to controls; however high-serum level of Homocysteine had no association with MTHFR polymorphism. No association of serum vitamin B12 with MTHFR polymorphism in occurrence of Down syndrome births was found. Peri- or preconceptional folate supplementation may therefore lead to a decline in DS births, if supported by larger studies. (Source: Indian...
Source: Indian Journal of Human Genetics - March 4, 2013 Category: Genetics & Stem Cells Authors: Pankaj K MohantySeema KapoorAnand P DubeySanjeev PandeyRenuka ShahHemant K NayakSunil K Polipalli Source Type: research
Redefining the potential applications of dental stem cells: An asset for future
Shalu Rai, Mandeep Kaur, Sandeep Kaur, Sapna Panjwani AroraIndian Journal of Human Genetics 2012 18(3):276-284Recent exciting discoveries isolated dental stem cells from the pulp of the primary and permanent teeth, from the periodontal ligament, and from associated healthy tissues. Dental pulp stem cells (DPSCs) represent a kind of adult cell colony which has the potent capacity of self-renewing and multilineage differentiation. Stem cell-based tooth engineering is deemed as a promising approach to the making of a biological tooth (bio-tooth) or engineering of functional tooth structures. Dental professionals have the oppo...
Source: Indian Journal of Human Genetics - March 4, 2013 Category: Genetics & Stem Cells Authors: Shalu RaiMandeep KaurSandeep KaurSapna Panjwani Arora Source Type: research
Vitamin D receptor and type 2 diabetes mellitus: Growing therapeutic opportunities
Parmeet Kaur Manchanda, Hemant K BidIndian Journal of Human Genetics 2012 18(3):274-275 (Source: Indian Journal of Human Genetics)
Source: Indian Journal of Human Genetics - March 4, 2013 Category: Genetics & Stem Cells Authors: Parmeet Kaur ManchandaHemant K Bid Source Type: research
Small players with a big role: MicroRNAs in pathophysiology of cleft lip and palate
Uppala RadhakrishnaIndian Journal of Human Genetics 2012 18(3):272-273 (Source: Indian Journal of Human Genetics)
Source: Indian Journal of Human Genetics - March 4, 2013 Category: Genetics & Stem Cells Authors: Uppala Radhakrishna Source Type: research
Annoucement
Kanjaksha GhoshIndian Journal of Human Genetics 2012 18(3):271-271 (Source: Indian Journal of Human Genetics)
Source: Indian Journal of Human Genetics - March 4, 2013 Category: Genetics & Stem Cells Authors: Kanjaksha Ghosh Source Type: research
