Prevalence of FVIII inhibitors in severe haemophilia A patients: Effect of treatment and genetic factors in an Indian population
ConclusionThe overall prevalence of inhibitors in patients with severe haemophilia A is similar to that reported among patients receiving regular replacement therapy. The data from this study, limited by its retrospective and cross ‐sectional study design, would suggest that genetic rather than environmental are more likely to impact the development of inhibitors. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Sachin David,
Sukesh C. Nair,
G. Surender Singh,
Ansu Abu Alex,
Saravanan Ganesan,
Hamenth Kumar Palani,
Nithya Balasundaram,
Kavitha M. Lakshmi,
Aditi Joshi,
S. Kannan,
Anu Korula,
Fouzia Nambiatheyil Aboobacker,
Aby Abraham,
Biju George,
S Tags: ORIGINAL ARTICLE Source Type: research
Sports participation and physical activity in patients with von Willebrand disease
ConclusionThe majority of VWD patients participated in sports. Patients with type 3 VWD, a history of joint bleeds and a more severe bleeding phenotype frequently experienced limitations in sports participation and physical activities during daily life. (Source: Haemophilia)
Source: Haemophilia - November 14, 2018 Category: Hematology Authors: Ferdows Atiq,
Eveline P. Mauser ‐Bunschoten,
Jeroen Eikenboom,
Karin P. M. van Galen,
Karina Meijer,
Joke de Meris,
Marjon H. Cnossen,
Erick A. M. Beckers,
Britta A. P. Laros‐van Gorkom,
Laurens Nieuwenhuizen,
Johanna G. van der Bom,
Karin Tags: ORIGINAL ARTICLE Source Type: research
Concizumab restores thrombin generation potential in patients with haemophilia: Pharmacokinetic/pharmacodynamic modelling results of concizumab phase 1/1b data
ConclusionConcizumab phase 2 trials will target an exposure ≥100 ng/mL, with a once‐daily regimen. (Source: Haemophilia)
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Hermann Eichler,
Pantep Angchaisuksiri,
Kaan Kavakli,
Paul Knoebl,
Jerzy Windyga,
Victor Jim énez‐Yuste,
Philip Harder Delff,
Pratima Chowdary Tags: ORIGINAL ARTICLE Source Type: research
Severe acquired von Willebrand syndrome secondary to systemic lupus erythematosus
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Francesca Stufano,
Luciano Baronciani,
Eugenia Biguzzi,
Giovanna Cozzi,
Paola Colpani,
Marta Chisini,
Flora Peyvandi Tags: LETTER TO THE EDITOR Source Type: research
Treatment regimens and outcomes in severe and moderate haemophilia A in the UK: The THUNDER study
ConclusionsIncreasing ABR with age persists despite current prophylaxis regimens. SHA and MHA had similar ABR/AJBR and HJHS, leading to a suspicion that a subgroup of MHA may be relatively undertreated. More intensive prophylaxis may improve outcomes, but this requires further study. (Source: Haemophilia)
Source: Haemophilia - November 8, 2018 Category: Hematology Authors: Martin J. Scott,
Hua Xiang,
Daniel P. Hart,
Benedict Palmer,
Peter W. Collins,
David Stephensen,
Camelia S. Sima,
Charles R. M. Hay Tags: ORIGINAL ARTICLE Source Type: research
Long ‐term safety and efficacy of turoctocog alfa in prophylaxis and treatment of bleeding episodes in severe haemophilia A: Final results from the guardian 2 extension trial
ConclusionExtended use of turoctocog alfa is safe and effective for prevention and treatment of bleeding episodes in previously treated patients with haemophilia A across all ages. (Source: Haemophilia)
Source: Haemophilia - November 6, 2018 Category: Hematology Authors: Steven R. Lentz,
Dragana Janic,
Kaan Kavakli,
Predrag Miljic,
Johannes Oldenburg,
Margareth C. Ozelo,
Elena Santagostino,
Takashi Suzuki,
Silva Zupancic Šalek,
Lars Korsholm,
Irina Matytsina,
Andreas Tiede Tags: ORIGINAL ARTICLE Source Type: research
The prevalence and burden of hand and wrist bleeds in von Willebrand disease
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 5, 2018 Category: Hematology Authors: D ésirée van Deukeren,
Eveline P. Mauser‐Bunschoten,
Roger E. G. Schutgens,
Jeroen Eikenboom,
Karina Meijer,
Karin Fijnvandraat,
Britta A. P. Laros‐van Gorkom,
Marjon Cnossen,
Joke de Meris,
Johanna G. van der Bom,
Frank W. G. Leebeek,
Ka Source Type: research
Continuous infusion of simoctocog alfa in haemophilia A patients undergoing surgeries
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - November 5, 2018 Category: Hematology Authors: P ål Andre Holme,
Geir E. Tjønnfjord Source Type: research
Assessment of tensile mechanical properties of the Achilles tendon in adult patients with haemophilic arthropathy. Reproducibility study
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 30, 2018 Category: Hematology Authors: Carlos Cruz ‐Montecinos,
Sofía Pérez‐Alenda,
Felipe Contreras‐Sepúlveda,
Felipe Querol,
Mauricio Cerda,
Huub Maas Source Type: research
Thromboelastography and thrombin generation assay in inherited afibrinogenemia
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 22, 2018 Category: Hematology Authors: Guy Aaron Young,
Roxana Carmona,
Viridiana Cano Garcia Source Type: research
Improving access to haemophilia therapies —Beyond humanitarian aid
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 12, 2018 Category: Hematology Authors: Albert Farrugia,
Giancarlo Liumbruno,
Gabriele Calizzani,
Fabio Candura,
Samantha Profili,
Josephine Cassar Source Type: research
Use of two complementary new molecular techniques, next ‐generation sequencing and droplet digital PCR, for diagnosis of an F8 gene deletion and subsequent carrier analysis in a family with haemophilia A: A Case Report
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 9, 2018 Category: Hematology Authors: Priyanka Gangodkar,
Shatakshi Ranade,
Siddharth Anand,
Ashwini Bapat,
Kavita Khatod,
Parth Shah,
Meenal Agarwal,
Nikhil Phadke Source Type: research
Bleeding events and safety outcomes in persons with haemophilia A with inhibitors: A prospective, multi ‐centre, non‐interventional study
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 8, 2018 Category: Hematology Authors: Johnny Mahlangu,
Johannes Oldenburg,
Michael U. Callaghan,
Midori Shima,
Elena Santagostino,
Maggie Moore,
Michael Recht,
Claudia Garcia,
Renchi Yang,
Michaela Lehle,
Harrison Macharia,
Elina Asikanius,
Gallia G. Levy,
Rebecca Kruse ‐Jarres Source Type: research
Investigating the relationship between the HJHS and HAL in routine clinical practice: A retrospective review
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 8, 2018 Category: Hematology Authors: Paul McLaughlin,
Richard Morris,
Pratima Chowdary Source Type: research
Usefulness of bone microarchitectural and geometric DXA ‐derived parameters in haemophilic patients
Haemophilia, EarlyView. (Source: Haemophilia)
Source: Haemophilia - October 1, 2018 Category: Hematology Authors: Fabio Massimo Ulivieri,
Giulia Antonella Angela Rebagliati,
Luca Petruccio Piodi,
Luigi Piero Solimeno,
Gianluigi Pasta,
Elena Boccalandro,
Maria Rosaria Fasulo,
Maria Elisa Mancuso,
Elena Santagostino Source Type: research
