Egyptian Journal of Medical Human Genetics This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

New insights into smudge cell percentage in chronic lymphocytic Leukemia: A novel prognostic indicator of disease burden
Conclusion low percentage of smudge cells (<30%) could be considered as an adverse prognostic predictor being associated with high risk markers in CLL. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

Detection of antimicrobial resistance genes of Helicobacter pylori strains to clarithromycin, metronidazole, amoxicillin and tetracycline among Egyptian patients
Conclusion Data concerning antimicrobial resistance genes play an important role in empiric treatment of H. pylori infection. According to our results, H. pylori resistance to metronidazole and amoxicillin was relatively high. Clarithromycin is still a good option for first line anti-H. pylori treatment. Combined resistant strains are emerging and may have an effect on the combination therapy. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

Metadherin mRNA expression in hepatocellular carcinoma
Conclusion MTDH mRNA is up-regulated in serum of HCC patients; MTDH may be considered as non-invasive biomarker for HCC diagnosis and it could replace serum AFP in HCC diagnosis as it had higher accuracy. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

Study of the role of IL-17F gene polymorphism in the development of immune thrombocytopenia among the Egyptian children
Conclusion Our study suggests that IL17F gene polymorphism at rs7488A/G may not contribute to the susceptibility in development of primary immune thrombocytopenia in the Egyptian children. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

Renalase gene polymorphisms (rs2576178 and rs10887800) in Egyptian hypertensive end stage renal disease patients
Conclusion Our study revealed that the risk of developing end stage renal diseases was increased among carriers of AA genotype for the rs10887800 polymorphism and GG genotype for the rs2576178 polymorphism. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

The cephalofacial characterization in humans: The study using igbo tribe in Nigeria
Conclusion the study characterized anthropometrics of face and head of Igbos in the South-Eastern region of Nigeria. From this study, Igbo ethnic group fall under the platyrrhine type of nose. Igbo males and Igbo females are mesocephalic from this study. On the average from this work, the mean C.I. in the Igbo tribe belongs to mesocephalic or medium headed population. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - March 9, 2018 Category: Genetics & Stem Cells Source Type: research

No association between the SNP rs1625579 in miR-137 gene and schizophrenia in Iranian population
Conclusion There was no significant relationship between rs1625579 and the incidence of schizophrenia. To the best of our knowledge, this is first study in Iran that assesses the frequency of the polymorphism among Iranian patients. However, further studies with more samples are necessary. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - January 7, 2018 Category: Genetics & Stem Cells Source Type: research

Association of P2X7 gene common polymorphisms with pulmonary tuberculosis in Lur population of Iran
Conclusion In Lur population of Iran, 1513A/C polymorphism of P2X7 is associated with susceptibility to pulmonary TB. It is suggested that bio-information banks should be established and developed in countries. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - January 6, 2018 Category: Genetics & Stem Cells Source Type: research

Association of interleukin-6 and its -174G/C promoter polymorphism with clinical and laboratory characteristics of non hepatitis C virus rheumatoid arthritis patients
Conclusion Serum IL-6 levels and -174G/C promoter polymorphism were higher in RA patients than in healthy controls. The positive correlation of IL-6 level with the DAS28 and duration of morning stiffness may confirm its’ increased involvement in the pathogenesis of RA and may point to the need for considering of anti-IL-6 agents in their management plan. The negative correlation of IL-6 level with the hemoglobin level may confirm IL-6 play a significant role in anemia of RA. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - January 6, 2018 Category: Genetics & Stem Cells Source Type: research

Impact of cell death pathway genes Fas 21377AA and FasL 2844CC polymorphisms on the risk of developing non-small cell lung cancer
Conclusion The interaction of the cell death pathway genes Fas and FasL polymorphisms could be associated with the risk of lung cancer, in the same respect Fas AA genotype could also potentiate this risk. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 27, 2017 Category: Genetics & Stem Cells Source Type: research

Progress in genetics of coronary artery disease
Publication date: Available online 18 December 2017 Source:Egyptian Journal of Medical Human Genetics Author(s): Radwa Gamal (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 19, 2017 Category: Genetics & Stem Cells Source Type: research

Oncolytic virotherapy – A novel strategy for cancer therapy
Publication date: Available online 14 December 2017 Source:Egyptian Journal of Medical Human Genetics Author(s): Mohanan Geetha Gopisankar, A. Surendiran Oncolytic virotherapy is a new modality of cancer treatment which uses competent replicating viruses to destroy cancer cells. This field progressed from earlier observations of accidental viral infections causing remission in many malignancies to virus drugs targeting and killing cancer cells. More competent and specific viruses which attack tumor cells but not healthy cells could be made with advancements in the field of genetic engineering. Studying virus as a drug ...
Source: Egyptian Journal of Medical Human Genetics - December 15, 2017 Category: Genetics & Stem Cells Source Type: research

Common variant of 5,10-methylenetetrahydrofolate reductase may increase risk of coronary artery disease in the Iranian population
Conclusion The results of this study showed that C/T genotype in MTHFR C677T position is a causative factor, especially in women, and might be associated with susceptibility to CAD in the Iranian population. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 8, 2017 Category: Genetics & Stem Cells Source Type: research

A modified protocol for highly efficient EBV-mediated immortalization of human B lymphocytes from small volumes of peripheral blood serum
Conclusion The method is applicable for immortalization of B lymphocytes from small blood samples and is essential for studies involving children or patients when large blood volume sampling is impossible. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 7, 2017 Category: Genetics & Stem Cells Source Type: research

Robertsonian translocation 13/14 associated with rRNA genes overexpression and intellectual disability
Conclusion The translocated chromosome in the proband was most likely inherited from the mother and did not come about de novo with normal chromosomes 13 and 14 being obtained from the father. The cause of the pathogenesis in the proband still remains unknown. We hypothesize that it could be caused by impaired imprinting manifesting in altered methylation levels of loci on the derivative chromosome. (Source: Egyptian Journal of Medical Human Genetics)
Source: Egyptian Journal of Medical Human Genetics - December 1, 2017 Category: Genetics & Stem Cells Source Type: research