Current status of Severe Fever with Thrombocytopenia Syndrome vaccine development
Publication date: April 2018 Source:Current Opinion in Virology, Volume 29 Author(s): Lisa M Reece, David WC Beasley, Gregg N Milligan, Vanessa V Sarathy, Alan DT Barrett Severe Fever with Thrombocytopenia Syndrome (SFTS) is a new emerging tick-borne disease caused by the phlebovirus, SFTS virus (SFTSV). The virus was discovered in central China in 2009 and has since been identified in both Japan and South Korea. Significant progress has been made on the molecular biology of the virus, and this has been used to develop diagnostic assays and reagents. Less progress has been made on the epidemiology, maintenance and t...
Source: Current Opinion in Virology - April 10, 2018 Category: Virology Source Type: research
The use of humanized mice for studies of viral pathogenesis and immunity
Publication date: April 2018 Source:Current Opinion in Virology, Volume 29 Author(s): Florian Douam, Alexander Ploss Humanized mice, that is, animals engrafted with human tissues and/or expressing human genes, have been instrumental in improving our understanding of the pathogenesis and immunological processes that define some of the most challenging human-tropic viruses. In particular, mice engrafted with components of a human immune system (HIS) offer unprecedented opportunities for mechanistic studies of human immune responses to infection. Here, we provide a brief overview of the current panel of HIS mouse models a...
Source: Current Opinion in Virology - March 29, 2018 Category: Virology Source Type: research
The use of longitudinal cohorts for studies of dengue viral pathogenesis and protection
We describe how longitudinal cohorts enable measurement of essential disease parameters and risk factors; provide insights into biological correlates of protection and disease risk; enable rapid application of novel biological and statistical technologies; lead to development of new interventions and inform vaccine trial design; serve as sentinels in outbreak conditions and facilitate development of critical diagnostic assays; enable holistic studies on disease in the context of other infections, comorbidities, and environmental risk factors; and build research capacity that strengthens national and global public health re...
Source: Current Opinion in Virology - March 27, 2018 Category: Virology Source Type: research
The use of single-cell RNA-Seq to understand virus –host interactions
Publication date: April 2018 Source:Current Opinion in Virology, Volume 29 Author(s): Sara Cristinelli, Angela Ciuffi Single-cell analyses allow uncovering cellular heterogeneity, not only per se, but also in response to viral infection. Similarly, single cell transcriptome analyses (scRNA-Seq) can highlight specific signatures, identifying cell subsets with particular phenotypes, which are relevant in the understanding of virus–host interactions. Graphical abstract (Source: Current Opinion in Virology)
Source: Current Opinion in Virology - March 19, 2018 Category: Virology Source Type: research
Recent advances in veterinary applications of structural vaccinology
Publication date: April 2018 Source:Current Opinion in Virology, Volume 29 Author(s): Bryan Charleston, Simon P Graham The deployment of effective veterinary vaccines has had a major impact on improving food security and consequently human health. Effective vaccines were essential for the global eradication of Rinderpest and the control and eradication of foot-and-mouth disease in some regions of the world. Effective vaccines also underpin the development of modern intensive food production systems such as poultry and aquaculture. However, for some high consequence diseases there are still significant challenges to dev...
Source: Current Opinion in Virology - March 17, 2018 Category: Virology Source Type: research
