Discussion on the paper “Considerations of multiple imputation approaches for handling missing data in clinical trials”, by H Quan, L Qi, X Luo, and L Darchy
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 23, 2019 Category: Radiology Authors: Guanghan Liu, Man Jin, Lei Pang Tags: Letter to the Editor Source Type: research
Improving the quality conduct and efficiency of clinical trials with training: Recommendations for preparedness and qualification of investigators and delegates
The Clinical Trials Transformation Initiative (CTTI) Investigator Qualification Project addresses the need for a more efficient and effective means of identifying qualified clinical investigators and delegates. Selection of investigators and delegates who are qualified by training and experience to conduct clinical trials is essential to safeguarding protections for study participants and ensuring data quality and integrity. Sponsors generally document investigator qualification through training on the principles of good clinical practice (GCP), as defined by the International Council for Harmonisation of Technical Require...
Source: Contemporary Clinical Trials - December 23, 2019 Category: Radiology Authors: Jimmy Bechtel, Tina Chuck, Annemarie Forrest, Christine Hildebrand, Janette Panhuis, Suzanne R. Pattee, Sabrina Comc-Savic, Teresa Swezey Source Type: research
Patient randomized trial of a targeted navigation program to improve rates of follow-up colonoscopy in community health centers
Colorectal cancer (CRC) screening by annual fecal immunochemical test (FIT) is an accessible and cost-effective strategy to lower CRC incidence and mortality. However, this mode of screening depends on follow-up colonoscopy after a positive FIT result. Unfortunately, nearly one-half of FIT-positive patients fail to complete this essential screening component. Patient navigation may improve follow-up colonoscopy adherence. To deliver patient navigation cost-effectively, health centers could target navigation to patients who are unlikely to complete the procedure on their own. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 23, 2019 Category: Radiology Authors: Gloria D. Coronado, Eric S. Johnson, Michael C. Leo, Jennifer L. Schneider, David Smith, Raj Mummadi, Amanda F. Petrik, Jamie H. Thompson, Ricardo Jimenez Source Type: research
Cenicriviroc for the treatment of liver fibrosis in adults with nonalcoholic steatohepatitis: AURORA Phase 3 study design
Nonalcoholic steatohepatitis (NASH) is a sub-classification of nonalcoholic fatty liver disease (NAFLD) characterized by increased risk of progressive liver fibrosis. Cenicriviroc (CVC) is a novel, orally administered, potent chemokine 2 and 5 receptor antagonist currently in development for the treatment of liver fibrosis in adults with NASH. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 23, 2019 Category: Radiology Authors: Quentin M. Anstee, Brent A. Neuschwander-Tetri, Vincent Wai-Sun Wong, Manal F. Abdelmalek, Zobair M. Younossi, Jiacheng Yuan, Maria Lucia Pecoraro, Star Seyedkazemi, Laurent Fischer, Pierre Bedossa, Zachary Goodman, Naim Alkhouri, Frank Tacke, Arun Sanyal Source Type: research
Communicating health information and improving coordination with primary care (CHIIP): Rationale and design of a randomized cardiovascular health promotion trial for adult survivors of childhood cancer
Long-term survival for children diagnosed with cancer exceeds 80%. Notably, premature cardiovascular disease has become the leading non-cancer cause of late mortality among these survivors. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 16, 2019 Category: Radiology Authors: Eric J. Chow, Laura-Mae Baldwin, Anna Hagen, Melissa M. Hudson, Todd M. Gibson, Komal Kochar, Aaron McDonald, Paul C. Nathan, Karen Syrjala, Sarah L. Taylor, Emily S. Tonorezos, Yutaka Yasui, Gregory T. Armstrong, Kevin C. Oeffinger Source Type: research
Rationale, design, and development of SleepWell24: A smartphone application to promote adherence to positive airway pressure therapy among patients with obstructive sleep apnea
Positive airway pressure (PAP) therapy is the gold standard treatment for obstructive sleep apnea (OSA), a chronic disorder that affects 6 –13% of the adult population. However, adherence to PAP therapy is challenging, and current approaches to improve adherence have limited efficacy and scalability. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 12, 2019 Category: Radiology Authors: Megan E. Petrov, Kristina Hasanaj, Coles M. Hoffmann, Dana R. Epstein, Lois Krahn, John G. Park, Kevin Hollingshead, Tsung-Yen Yu, Michael Todd, Erik K. St. Louis, Timothy I. Morgenthaler, Matthew P. Buman Source Type: research
Methods and rationale to assess the efficacy of a parenting intervention targeting diet improvement and substance use prevention among Latinx adolescents
This article describes the design and theoretical rationale of a study assessing the effects of Families Preparing the New Generation Plus (FPNG Plus), a 10-week culturally-tailored nutrition and substance use prevention parenting program, on diet and substance use outcomes among Latinx middle school students (6th –8th grade). (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 12, 2019 Category: Radiology Authors: Sonia Vega-L ópez, Flavio F. Marsiglia, Stephanie Ayers, Lela Rankin Williams, Meg Bruening, Anaid Gonzalvez, Beatriz Vega-Luna, Alex Perilla, Mary Harthun, Gabriel Q. Shaibi, Freddy Delgado, Christian Rosario, Leopoldo Hartmann Source Type: research
Wood stove interventions and child respiratory infections in rural communities: KidsAir rationale and methods
Acute lower respiratory tract infections (LRTIs) account for>27% of all hospitalizations among US children under five years of age. Residential burning of biomass for heat leads to elevated indoor levels of fine particulate matter (PM2.5) that often exceed current health based air quality standards. This is concerning as PM2.5 exposure is associated with many adverse health outcomes, including a greater than three-fold increased risk of LRTIs. Evidence-based efforts are warranted in rural and American Indian/Alaska Native (AI/AN) communities in the US that suffer from elevated rates of childhood LRTI and commonly use wood ...
Source: Contemporary Clinical Trials - December 11, 2019 Category: Radiology Authors: Curtis W. Noonan, Erin O. Semmens, Desirae Ware, Paul Smith, Bert B. Boyer, Esther Erdei, Scarlett E. Hopkins, Johnnye Lewis, Tony J. Ward Source Type: research
Results of the CYP-GUIDES randomized controlled trial: Total cohort and primary endpoints
CYP-GUIDES (Cytochrome Psychotropic Genotyping Under Investigation for Decision Support) is a randomized controlled trial (RCT) comparing 2 outcomes in hospitalized patients with major depressive disorder (MDD) treated according to the patient's CYP2D6 genotype and functional status versus standard psychotropic therapy. The primary outcome was hospital Length of Stay (LOS) and the secondary outcome was the Re-Admission Rate (RAR) 30 days after discharge.The trial setting was the Institute of Living at Hartford Hospital. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 11, 2019 Category: Radiology Authors: Gualberto Rua ño, Saskia Robinson, Theodore Holford, Raveen Mehendru, Seth Baker, Joseph Tortora, John W. Goethe Source Type: research
Mobility and outcomes for validated evidence – Incentive trial (MOVE IT): Randomized clinical trial study protocol
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 11, 2019 Category: Radiology Authors: Heather M. Greysen, Catherine Reale, Ashley Mercede, Mitesh S. Patel, Dylan Small, Chris Snider, Charles Rareshide, Scott D. Halpern, S. Ryan Greysen Source Type: research
Program to improve mobility in aging (PRIMA) study: Methods and rationale of a task-oriented motor learning exercise program
We describe the methods and rationale of a randomized single-blind, physical therapist supervised, exercise intervention trial to compare the effects of a standard strength, endurance, and flexibility program to a standard plus timing and coordination program in community-dwelling older adults walking slower than the desired gait speed of 1.2 m/s. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 11, 2019 Category: Radiology Authors: Jennifer S. Brach, Jessie M. VanSwearingen, Alexandra Gil, Neelesh K. Nadkarni, Andrea Kriska, Rakie Cham, Subashan Perera Source Type: research
Strategy of blood pressure intervention in the elderly hypertensive patients (STEP): Rational, design, and baseline characteristics for the main trial
The optimal systolic blood pressure (SBP) treatment target in elderly people is full of challenge, and non-adherence is one major cause of uncontrolled BP. The Strategy of Blood Pressure Intervention in the Elderly Hypertensive Patients (STEP) trial is a multi-center, randomized controlled trial that aims to examine whether an intensive treatment (110 ≤ SBP (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - December 11, 2019 Category: Radiology Authors: Shuyuan Zhang, Shouling Wu, Jie Ren, Xiaoping Chen, Xinjun Zhang, Yingqing Feng, Xiaoyang Zhou, Bingpo Zhu, Jinfeng Yang, Gang Tian, Yinong Jiang, Zihong Guo, Yuming Li, Tzung-Dau Wang, Kazuomi Kario, Weili Zhang, Jun Cai, On behalf of the STEP Study Grou Source Type: research
Corrigendum to “Design and participant characteristics of TX sprouts: A school-based cluster randomized gardening, nutrition, and cooking intervention” [Contemp Clin Trials 85 (2019) 105834]
The authors regret that the sex was mislabelled in Table 6, females should be replaced with males in row 2 of this table. The authors would like to apologise for any inconvenience caused. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - November 28, 2019 Category: Radiology Authors: Jaimie N. Davis, Katie Nikah, Fiona M. Asigbee, Matthew J. Landry, Sarvenaz Vandyousefi, Reem Ghaddar, Amy Hoover, Matthew Jeans, Stephen J. Pont, Daphne Richards, Deanna M. Hoelscher, Alexandra E. Van Den Berg, Meagan Bluestein, Adriana P érez Tags: Corrigendum Source Type: research
A randomized controlled trial of a trauma-informed school prevention program for urban youth: Rationale, design, and methods
Youth in disadvantaged urban areas are frequently exposed to chronic stress and trauma, including housing instability, neighborhood violence, and other poverty-related adversities. These exposures increase risk for emotional, behavioral, and academic problems and ultimately, school dropout. Schools are a promising setting in which to address these issues; however, there are few universal, trauma-informed school-based interventions for urban youth. (Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - November 27, 2019 Category: Radiology Authors: Tamar Mendelson, Laura K. Clary, Erica Sibinga, Darius Tandon, Rashelle Musci, Kristin Mmari, David Salkever, Elizabeth Stuart, Nick Ialongo Source Type: research
Conceivable utility of the electrocardiogram in the N-acetylcysteine and RAMipril in takotsubo syndrome trial (NACRAM)
(Source: Contemporary Clinical Trials)
Source: Contemporary Clinical Trials - November 27, 2019 Category: Radiology Authors: John E. Madias Tags: Correspondence Source Type: research
