ACTG A5257: Virologic Failure on Initial ART More Likely in Women, Black and Hispanic Patients in US
Conference Capsule - Adherence to treatment remains most important predictor of response. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 29, 2016 Category: Infectious Diseases Source Type: research
IMPAACT PROMISE P1084s: Including Tenofovir DF in Maternal 3-Drug ART Regimen During Pregnancy Not Associated With Lower Bone Mineral Content in HIV-Exposed Newborns
Conference Capsule - Lopinavir/ritonavir-containing 3-drug ART regimen started in pregnancy associated with significantly lower whole-body bone mineral content in newborns vs zidovudine monotherapy plus single-dose nevirapine with a tenofovir DF/emtricitabine tail. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 29, 2016 Category: Infectious Diseases Source Type: research
LATTE-2: Long-Acting Intramuscular Cabotegravir Plus Rilpivirine Effective and Well Tolerated as HIV-1 Maintenance Regimen
Conference Capsule - Intramuscular cabotegravir regimen administered every 4 or 8 weeks showed similar virologic efficacy as oral cabotegravir regimen with mild injection-site reactions. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
Study 311-1089: Switch to FTC/TAF Noninferior to Continued FTC/TDF in Patients on Stable FTC/TDF Plus Third Agent
Conference Capsule - Switch to the novel NRTI coformulation FTC/TAF associated with improvements in bone and renal biomarkers. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
iPrEx Substudy: BMD Lost During PrEP Use Is Recovered Following Treatment Discontinuation
Conference Capsule - BMD recovery rate appears slower in adults aged 25 years and older. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
IMPAACT P1026s: Dolutegravir Pharmacokinetic Parameters in Pregnancy and Postpartum
Conference Capsule - First assessment of dolutegravir activity in pregnant women finds exposures vary within the normal range. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
HPTN 069/ACTG 5305: Maraviroc-Containing PrEP Regimens Well Tolerated in MSM in Phase II Study
Conference Capsule - Randomized study suggests further evaluation of maraviroc in PrEP strategies may be warranted. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
MK-1439-007: Novel NNRTI, Doravirine Plus TDF/FTC Demonstrates Efficacy in ART-Naive Patients in Phase II Trial
Conference Capsule - Efficacy was comparable to that of efavirenz in the overall study group; drug-related AEs, specific CNS events less frequent with doravirine vs efavirenz. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 26, 2016 Category: Infectious Diseases Source Type: research
EuroSIDA: In Observational Cohort, Current or Past Exposure to Tenofovir DF Associated With Increased Fracture Risk in HIV-Infected Patients
Conference Capsule - Numerous other factors associated with fracture risk, including past fracture or osteonecrosis and lower CD4+ cell count. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 25, 2016 Category: Infectious Diseases Source Type: research
ACTG 5273: Second-line Lopinavir/Ritonavir Plus Raltegravir Noninferior to Lopinavir/Ritonavir Plus NRTIs in Resource-Limited Settings
Conference Capsule - Results in line with earlier findings of EARNEST and SECOND-LINE studies. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 25, 2016 Category: Infectious Diseases Source Type: research
Contemporary Management of HIV: Modifying Antiretroviral Therapy in Virologically Suppressed Patients and Those With Treatment Failure
Slideset - In this downloadable slideset, W. David Hardy, MD, and Program Director Eric S. Daar, MD review key data and optimal approaches for modifying ART in patients who are virologically suppressed or have experienced treatment failure. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 17, 2016 Category: Infectious Diseases Source Type: research
Contemporary Management of HIV: Managing ART in HIV-Infected Patients With Common Comorbidities
Slideset - In this downloadable slideset, David A. Wohl, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for managing ART in the context of common comorbidities. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 9, 2016 Category: Infectious Diseases Source Type: research
Contemporary Management of HIV: Managing HIV in Viral Hepatitis Coinfection
Slideset - In this downloadable slideset, David L. Wyles, MD, and Program Director Eric S. Daar, MD, review key data and optimal approaches for ART management in patients with HIV and viral hepatitis coinfection. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 9, 2016 Category: Infectious Diseases Source Type: research
Contemporary Management of HIV: When to Start, What to Start
Slideset - In this downloadable slideset, Daniel R. Kuritzkes, MD, and Program Director Eric S. Daar, MD review key data and optimal approaches for first-line ART with contemporary HIV regimens. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - February 9, 2016 Category: Infectious Diseases Source Type: research
Switch Strategies in Virologically Suppressed Patients: My Take on New Data From Recent Scientific Meetings
Discussion - Several recent studies have highlighted new approaches to ART switching. Some may expand our options for optimizing long-term virologic suppression in our patients; each should be scrutinized carefully before incorporating into practice. (Source: Clinical Care Options HIV)
Source: Clinical Care Options HIV - January 22, 2016 Category: Infectious Diseases Source Type: research
