Impact of graft ‐versus‐lymphoma effect on outcomes after reduced intensity conditioned‐alemtuzumab allogeneic haematopoietic stem cell transplantation for patients with mature lymphoid malignancies
SummaryAllogeneic haematopoietic stem cell transplant (allo ‐HSCT) offers potentially curative therapy for patients with relapsed/refractory lymphoid malignancies. Reduced‐intensity conditioning (RIC) with Alemtuzumab reduces transplant‐related mortality and graft‐versus‐host disease (GvHD), but may be associated with increased risk of relapse. Wit h the aim of studying the effect of GVHD and donor lymphocyte infusions (DLI) on relapse, we performed a retrospective study of 288 patients (57% non‐Hodgkin lymphoma, 24% Hodgkin lymphoma and 19% chronic lymphocytic leukaemia; 58% were relapsed/refractory) who under...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Charlotte K. Brierley,
Francesca M. Jones,
Katharine Hanlon,
Andy J. Peniket,
Chris Hatton,
Graham P. Collins,
Anna Schuh,
Patrick Medd,
Andrew Clark,
Janice Ward,
Sridar Chaganti,
Ram Malladi,
Anne Parker,
Charles Craddock,
Robert Danby,
V Tags: Research Paper Source Type: research
Cardiac biomarkers and health ‐related quality of life in patients with light chain (AL) amyloidosis
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Kristen L. McCausland,
Tiffany P. Quock,
Avery A. Rizio,
Martha S. Bayliss,
Michelle K. White,
Spencer D. Guthrie,
Vaishali Sanchorawala Tags: Correspondence Source Type: research
New insights into red cell rheology and adhesion in patients with sickle cell anaemia during vaso ‐occlusive crises
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Claudine Lapoumeroulie,
Philippe Connes,
Sara El Hoss,
Regine Hierso,
Keyne Charlot,
Nathalie Lemonne,
Jacques Elion,
Caroline Le Van Kim,
Marc Romana,
Marie ‐Dominique Hardy‐Dessources Tags: Correspondence Source Type: research
Prevalence and correlates of growth failure in young African patients with sickle cell disease
SummaryGrowth failure (GF) in children with sickle cell disease (SCD) tends to decline in high ‐income countries, but data are lacking in sub‐Saharan Africa. We performed a cross‐sectional study nested in the CADRE (Cœur, Artères et DREpanocytose) cohort in Mali, Senegal, Cameroon, Gabon and the Ivory Coast. SCD patients and healthy controls aged 5–21 years old were recruited (n = 2583). Frequency of GF, defined as a height, weight or body mass index below the 5th percentile on World health Organization growth charts, was calculated. We assessed associations between GF and SCD phenotypic group, clinical and bi...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Laure Alexandre ‐Heymann,
Marie Dubert,
Dapa A. Diallo,
Saliou Diop,
Aissata Tolo,
Suzanne Belinga,
Ibrahima Sanogo,
Ibrahima Diagne,
Guillaume Wamba,
Kouakou Boidy,
Indou Deme Ly,
Ismaël Kamara,
Youssouf Traore,
Lucile Offredo,
Xavier Jo Tags: Research Paper Source Type: research
Exome analysis of treatment ‐related AML after APL suggests secondary evolution
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Tianjiao Wang,
Meagan A. Jacoby,
Eric J. Duncavage,
Christopher A. Miller,
Sharon Heath,
Ramy Rahme,
Pierre Fenaux,
Lionel Ades,
Aline Renneville,
Bruno Cassinat,
Akihiro Takeshita,
Norio Asou,
Yasushi Miyazaki,
Hitoshi Kiyoi,
Farhad Ravandi Tags: Correspondence Source Type: research
Prophylactic donor lymphocyte infusion after allogeneic stem cell transplantation in acute leukaemia – a matched pair analysis by the Acute Leukaemia Working Party of EBMT
SummaryStrategies for relapse prevention after allogeneic transplantation in acute leukaemia are warranted. A registry ‐based matched‐pair analysis evaluated the efficacy of prophylactic donor lymphocyte infusion (proDLI). Adults receiving proDLI in complete remission (CR) and controls were pair‐matched for age, diagnosis, cytogenetics, stage, donor, gender, conditioning and T‐cell depletion. Eighty‐nine p airs were identified (median follow‐up: 6.9 years). Within the entire cohort, no difference was observed. However, among patients with high‐risk acute myeloid leukaemia (AML) (unfavourable cytogenetics and...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Christoph Schmid,
Myriam Labopin,
Nicolaas Schaap,
Hendrik Veelken,
Michael Schleuning,
Michael Stadler,
Juergen Finke,
Erin Hurst,
Frederic Baron,
Olle Ringden,
Gesine Bug,
Didier Blaise,
Johanna Tischer,
Adrian Bloor,
Jordi Esteve,
Sebast Tags: Short Report Source Type: research
Cancer specific survival in patients with sickle cell disease
SummarySickle cell disease (SCD) patients have a higher incidence of certain cancers, but no studies have determined the impact of cancer on survival among SCD patients. SCD patients (n = 6423), identified from state‐wide hospitalisation data, were linked to the California Cancer Registry (1988–2014). Multivariable Cox proportional hazards regression was used to examine survival. Among SCD patients, a cancer diagnosis was associated with a 3‐fold increased hazard of death. Compared to matched cancer patients without SCD, SCD was associated with worse overall survival, but not cancer‐specific survival, suggesting ...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Ann Brunson,
Theresa H. M. Keegan,
Anjlee Mahajan,
Susan Paulukonis,
Ted Wun Tags: Short Report Source Type: research
Evolution of multiple myeloma treatment practices in Europe from 2014 to 2016
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Marc S. Raab,
Leah Fink,
Paul Schoen,
Sebastian Gonzalez ‐McQuire,
Alain Flinois,
Michele Cavo,
Maria‐Victoria Mateos,
Kwee Yong Tags: Correspondence Source Type: research
Comment on: type 1 cryoglobulinaemia leading to gangrene of the toes and ischaemic ulceration
British Journal of Haematology, EarlyView. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Mathew Sheridan Tags: Correspondence Source Type: research
Differential expression of long non ‐coding RNAs are related to proliferation and histological diversity in follicular lymphomas
SummaryLong non ‐coding RNAs (lncRNAs) comprise a family of non‐coding transcripts that are emerging as relevant gene expression regulators of different processes, including tumour development. To determine the possible contribution of lncRNA to the pathogenesis of follicular lymphoma (FL) we performed RNA‐se quencing at high depth sequencing in primary FL samples ranging from grade 1‐3A to aggressive grade 3B variants using unpurified (n = 16) and purified (n = 12) tumour cell suspensions from nodal samples. FL grade 3B had a significantly higher number of differentially expressed lncRNAs (dif‐lncRNAs) with ...
Source: British Journal of Haematology - November 22, 2018 Category: Hematology Authors: Alejandro Roisman,
Giancarlo Castellano,
Alba Navarro,
Blanca Gonzalez ‐Farre,
Patricia Pérez‐Galan,
Anna Esteve‐Codina,
Marc Dabad,
Simon Heath,
Marta Gut,
Mattia Bosio,
Pau Bellot,
Philippe Salembier,
Albert Oliveras,
Irma Slavutsky, Tags: Research Paper Source Type: research
Risk factors affecting outcome of unrelated cord blood transplantation for children with familial haemophagocytic lymphohistiocytosis
SummaryAllogeneic haematopoietic stem cell transplantation is still the only available curative option for Familial Haemophagocytic Lymphohistiocytosis (FHLH). Most studies report outcomes after bone marrow or peripheral blood stem cell transplantation. We analysed the outcomes of 118 children with FHLH undergoing single ‐unit umbilical cord blood transplantation performed from 1996 to 2014. Myeloablative conditioning regimen was given to 90% of the patients, and was mostly busulfan‐based (n = 81, 76%), including anti‐thymocyte globulin or alemtuzumab (n = 102, 86%). The cumulative incidence of Day 60 neutrophil ...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Juliana Montibeller Furtado ‐Silva,
Annalisa Paviglianiti,
Annalisa Ruggeri,
Jaap Jan Boelens,
Paul Veys,
Ali Abdallah Ahmari,
Marco Zecca,
Franco Locatelli,
Gerard Michel,
Fernanda Volt,
Chantal Kenzey,
Petr Sedlacek,
Kanchan Rao,
Arjan La Tags: Research Paper Source Type: research
Effect of renin ‐angiotensin‐aldosterone system blocking agents on progression of glomerulopathy in sickle cell disease
SummaryAlthough renin ‐angiotensin‐aldosterone system (RAAS) blocking agents decrease albuminuria in short‐term studies, there is no evidence confirming their long‐term efficacy in sickle cell disease (SCD). In a single‐centre, retrospective study, we evaluated the long‐term effect of RAAS blocking agents on proteinuria and declining estimated glomerular filtration rates (eGFR). Eighty‐six patients on RAAS blocking agents for proteinuria, followed for a median of 2·28 years, were compared with 68 patients with proteinuria followed for 2·24 years who were not receiving such treatment. The log odds of prote...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Ashley Thrower,
Emily J. Ciccone,
Poulami Maitra,
Vimal K. Derebail,
Jianwen Cai,
Kenneth I. Ataga Tags: Research Paper Source Type: research
Outcome of patients aged 80 years or older treated for chronic lymphocytic leukaemia
SummaryClinical management of chronic lymphocytic leukaemia (CLL) in patients aged ≥80 years is based on limited evidence due to the lack of published information. Therefore, we analysed CLL patients aged ≥80 years using data from seven phase III clinical trials of the German CLL Study Group. Among 3552 participants, 152 were ≥80 years old at initiation of first‐line st udy treatment. Median age was 82 years (range 80–90). Concomitant diseases were present in 99% of the patients, with a median cumulative illness rating scale score of 8 (0–18). Chemoimmunotherapy with chlorambucil‐obinutuzumab (CLB‐OB) o...
Source: British Journal of Haematology - November 21, 2018 Category: Hematology Authors: Othman Al ‐Sawaf,
Jasmin Bahlo,
Sandra Robrecht,
Kirsten Fischer,
Carmen D. Herling,
Manuela Hoechstetter,
Anna‐Maria Fink,
Julia Tresckow,
Petra Langerbeins,
Paula Cramer,
Stephan Stilgenbauer,
Clemens M. Wendtner,
Barbara Eichhorst,
Mic Tags: Research Paper Source Type: research
Phase 2 study of all ‐oral ixazomib, cyclophosphamide and low‐dose dexamethasone for relapsed/refractory multiple myeloma
This study is registered at ClinicalTrials.gov (NCT02 046070). (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Shaji K. Kumar,
Norbert Grzasko,
Sosana Delimpasi,
Wieslaw W. Jedrzejczak,
Sebastian Grosicki,
Marie ‐Christine Kyrtsonis,
Andrew Spencer,
Neeraj Gupta,
Zhaoyang Teng,
Catriona Byrne,
Richard Labotka,
Meletios A. Dimopoulos Tags: Research Paper Source Type: research
Aplastic anaemia in pregnancy – a single centre, North American series
We describe 19 pregnancies in 9 women at a tertiary care centre over a period of 30 years. Spontaneous resolution of AA did not occur postpartum in the five pregnancies where AA was first diagnosed in pregnancy. In the remaining pregnancies, although haematological indices declined and transfusion support was needed in 35% of pregnancies, relapses were not observed. There were no deaths, but complications occurred in 79% of pregnancies. Preterm delivery and postpartum haemorrhage were observed in 21% and 26% of pregnancies, respectively. (Source: British Journal of Haematology)
Source: British Journal of Haematology - November 20, 2018 Category: Hematology Authors: Kelly E. McGowan,
Ann K. Malinowski,
Andre C. Schuh,
Wendy Whittle,
Nadine Shehata Tags: Short Report Source Type: research
