Red blood cells: beyond the transfusion
(Source: Blood)
Source: Blood - June 19, 2019 Category: Hematology Authors: Shaz, B. H. Tags: Free Research Articles COMMENTS Source Type: research
Gökbuget N, Dombret H, Bonifacio M, et al. Blinatumomab for minimal residual disease in adults with B-cell precursor acute lymphoblastic leukemia. Blood. 2018;131(14):1522-1531.
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Tags: Free Research Articles ERRATUM Source Type: research
Unusual case of a myelodysplastic syndrome with novel inv(5)(q15q33)
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Golden, R. J., Bogusz, A. M. Tags: Free Research Articles, BloodWork, Myeloid Neoplasia BLOOD WORK Source Type: research
HTLV-1-associated adult T-cell leukemia/lymphoma with disseminated strongyloidiasis
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Kwon, R., Duffield, A. S. Tags: Free Research Articles, BloodWork, Lymphoid Neoplasia BLOOD WORK Source Type: research
Archeogenetics of F11 p.Cys38Arg: a 5400-year-old mutation identified in different southwestern European countries
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: de la Morena-Barrio, M. E., Salloum-Asfar, S., Esteban, J., de la Morena-Barrio, B., Altisent, C., Martin-Fernandez, L., Gueguen, P., Padilla, J., Minano, A., Parra, R., Vicente, V., Vidal, F., Bauduer, F., Carbonell, P., Corral, J. Tags: Thrombosis and Hemostasis Letter to Blood Source Type: research
With equal access, African American patients have superior survival compared to white patients with multiple myeloma: a VA study
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Fillmore, N. R., Yellapragada, S. V., Ifeorah, C., Mehta, A., Cirstea, D., White, P. S., Rivero, G., Zimolzak, A., Pyarajan, S., Do, N., Brophy, M., Munshi, N. C. Tags: Multiple Myeloma, Sickle Cell Disease, Red Cells, Iron, and Erythropoiesis, Lymphoid Neoplasia, Clinical Trials and Observations Letter to Blood Source Type: research
Engineered Bcor mutations lead to acute leukemia of progenitor B-1 lymphocyte origin in a sensitized background
Approximately 10% of NUP98-PHF23 (NP23) mice develop an aggressive acute lymphoblastic leukemia of B-1 lymphocyte progenitor origin (pro-B1 ALL), accompanied by somatic frameshift mutations of the BCL6 interacting corepressor (Bcor) gene, most commonly within a 9-bp "hotspot" in Bcor exon 8. To determine whether experimentally engineered Bcor mutations would lead to pro-B1 ALL, we used clustered, regularly interspaced, short palindromic repeats–associated protein 9 to introduce a Bcor frameshift mutation into NP23 hematopoietic stem and progenitor cells through the use of Bcor small guide RNAs (Bcor sgRNAs). Recipien...
Source: Blood - June 12, 2019 Category: Hematology Authors: Yin, M., Chung, Y. J., Lindsley, R. C., Walker, R. L., Zhu, Y. J., Ebert, B. L., Meltzer, P. S., Aplan, P. D. Tags: Lymphoid Neoplasia, Brief Reports Source Type: research
Chronic CD30 signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells
CD30 is expressed on a variety of B-cell lymphomas, such as Hodgkin lymphoma, primary effusion lymphoma, and a diffuse large B-cell lymphoma subgroup. In normal tissues, CD30 is expressed on some activated B and T lymphocytes. However, the physiological function of CD30 signaling and its contribution to the generation of CD30+ lymphomas are still poorly understood. To gain a better understanding of CD30 signaling in B cells, we studied the expression of CD30 in different murine B-cell populations. We show that B1 cells expressed higher levels of CD30 than B2 cells and that CD30 was upregulated in IRF4+ plasmablasts (PBs). ...
Source: Blood - June 12, 2019 Category: Hematology Authors: Sperling, S., Fiedler, P., Lechner, M., Pollithy, A., Ehrenberg, S., Schiefer, A.-I., Kenner, L., Feuchtinger, A., Kühn, R., Swinerd, G., Schmidt-Supprian, M., Strobl, L. J., Zimber-Strobl, U. Tags: Lymphoid Neoplasia Source Type: research
Clinical and immunological features in a cohort of patients with partial DiGeorge syndrome followed at a single center
DiGeorge syndrome (DGS) is a primary immunodeficiency characterized by various degrees of T-cell deficiency. In partial DGS (pDGS), other risk factors could predispose to recurrent infections, autoimmunity, and allergy. The aim of this study was to assess the effect of different factors in the development of infections, autoimmunity, and/or allergy in patients with pDGS. We studied 467 pDGS patients in follow-up at Great Ormond Street Hospital. Using a multivariate approach, we observed that palatal anomalies represent a risk factor for the development of recurrent otitis media with effusion. Gastroesophageal reflux/dyspha...
Source: Blood - June 12, 2019 Category: Hematology Authors: Giardino, G., Radwan, N., Koletsi, P., Morrogh, D. M., Adams, S., Ip, W., Worth, A., Jones, A., Meyer-Parsonson, I., Gaspar, H. B., Gilmour, K., Davies, E. G., Ladomenou, F. Tags: Pediatric Hematology, Immunobiology and Immunotherapy Source Type: research
Treatment optimization and genomic outcomes in refractory severe aplastic anemia treated with eltrombopag
Eltrombopag (EPAG) received approval from the US Food and Drug Administration for the treatment of refractory severe aplastic anemia (rSAA) based on treatment of 43 patients with doses escalating from 50 to 150 mg daily for 12 weeks. Response kinetics suggested that more prolonged administration of EPAG at a dose of 150 mg could speed and improve response rates. We enrolled 40 patients with rSAA in a study of EPAG 150 mg daily, with a primary end point of response at 24 weeks. Twenty (50%) of 40 patients responded at 24 weeks; 5 (25%) of 20 would have been deemed nonresponders at 12 weeks, the end point of the previous stu...
Source: Blood - June 12, 2019 Category: Hematology Authors: Winkler, T., Fan, X., Cooper, J., Desmond, R., Young, D. J., Townsley, D. M., Scheinberg, P., Grasmeder, S., Larochelle, A., Desierto, M., Valdez, J., Lotter, J., Wu, C., Shalhoub, R. N., Calvo, K. R., Young, N. S., Dunbar, C. E. Tags: Hematopoiesis and Stem Cells, Clinical Trials and Observations Source Type: research
Acalabrutinib for mantle cell lymphoma
Mantle cell lymphoma (MCL) is a unique type of non-Hodgkin lymphoma characterized by the overexpression of cyclin D1. MCL patients typically live for years but experience multiple relapses. Acalabrutinib is a novel second-generation oral Bruton tyrosine kinase inhibitor approved by the US Food and Drug Administration for relapsed MCL based on a clinical trial demonstrating an overall response rate of 81%. It provides a valuable new treatment option for MCL patients and is now being tested upfront. (Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Witzig, T. E., Inwards, D. Tags: Lymphoid Neoplasia, Blood Spotlight Source Type: research
The heparin binding domain of von Willebrand factor binds to growth factors and promotes angiogenesis in wound healing
During wound healing, the distribution, availability, and signaling of growth factors (GFs) are orchestrated by their binding to extracellular matrix components in the wound microenvironment. Extracellular matrix proteins have been shown to modulate angiogenesis and promote wound healing through GF binding. The hemostatic protein von Willebrand factor (VWF) released by endothelial cells (ECs) in plasma and in the subendothelial matrix has been shown to regulate angiogenesis; this function is relevant to patients in whom VWF deficiency or dysfunction is associated with vascular malformations. Here, we show that VWF deficien...
Source: Blood - June 12, 2019 Category: Hematology Authors: Ishihara, J., Ishihara, A., Starke, R. D., Peghaire, C. R., Smith, K. E., McKinnon, T. A. J., Tabata, Y., Sasaki, K., White, M. J. V., Fukunaga, K., Laffan, M. A., Lutolf, M. P., Randi, A. M., Hubbell, J. A. Tags: Plenary Papers, Thrombosis and Hemostasis, Vascular Biology Source Type: research
B-1 progenitor acute lymphoid leukemia
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Yoshimoto, M. Tags: Free Research Articles COMMENTS Source Type: research
Eltrombopag: wielding a double-edged sword?
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: Babushok, D. V. Tags: Free Research Articles COMMENTS Source Type: research
von Willebrand factor promotes wound healing
(Source: Blood)
Source: Blood - June 12, 2019 Category: Hematology Authors: ODonnell, J. S., OSullivan, J. M. Tags: Free Research Articles COMMENTS Source Type: research
