Biopharmaceutics and Drug Disposition 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Issue Information
Biopharmaceutics&Drug Disposition,Volume 39, Issue 4, Page 185-186, April 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - April 26, 2018 Category: Drugs & Pharmacology Source Type: research
Effects of renal impairment on transporter ‐mediated renal reabsorption of drugs and renal drug–drug interactions: A simulation‐based study
Biopharmaceutics&Drug Disposition,Volume 39, Issue 4, Page 218-231, April 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - April 26, 2018 Category: Drugs & Pharmacology Authors: Kristin E.Follman
,
Rutwij A.Dave
,
Marilyn E.Morris Source Type: research
Amorphous solid dispersions of carvedilol along with pH ‐modifiers improved pharmacokinetic properties under hypochlorhydoria
Biopharmaceutics&Drug Disposition,Volume 39, Issue 4, Page 232-242, April 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - April 26, 2018 Category: Drugs & Pharmacology Authors: ShimulHalder
,
AikoTabata
,
YoshikiSeto
,
HideyukiSato
,
SatomiOnoue Source Type: research
Potencies of vitamin D analogs, 1 α‐hydroxyvitamin D3, 1α‐hydroxyvitamin D2 and 25‐hydroxyvitamin D3, in lowering cholesterol in hypercholesterolemic mice in vivo
Biopharmaceutics&Drug Disposition,Volume 39, Issue 4, Page 196-204, April 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - April 26, 2018 Category: Drugs & Pharmacology Authors: Holly P.Quach
,
TamaraDzekic
,
PaolaBukuroshi
,
K. SandyPang Source Type: research
Cytochrome P450 2C9 ‐natural antiarthritic interactions: Evaluation of inhibition magnitude and prediction from in vitro data
Biopharmaceutics&Drug Disposition, EarlyView. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 23, 2018 Category: Drugs & Pharmacology Source Type: research
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Biopharmaceutics&Drug Disposition, Ahead of Print. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 23, 2018 Category: Drugs & Pharmacology Source Type: research
Evaluation of the metabolic capability of primary human hepatocytes in three ‐dimensional cultures on microstructural plates
Biopharmaceutics&Drug Disposition, EarlyView. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Source Type: research
Issue Information
Biopharmaceutics&Drug Disposition,Volume 39, Issue 3, Page 123-124, March 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Source Type: research
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Biopharmaceutics&Drug Disposition, Ahead of Print. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Source Type: research
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Biopharmaceutics&Drug Disposition,Volume 39, Issue 3, Page 123-124, March 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Source Type: research
Verification of a physiologically based pharmacokinetic model of ritonavir to estimate drug –drug interaction potential of CYP3A4 substrates
In this study, four physiologically based pharmacokinetic (PBPK) models of ritonavir as an in vivo time‐dependent inhibitor of CYP3A4 were created and verified for oral doses of 20, 50, 100 and 200 mg using the fraction absorbed (Fa) and oral clearance (CLoral) values reported in the literature, because transporter and CYP enzyme reaction phenotyping data were not available. The models were used subsequently to predict and compare the magnitude of the AUC increase in nine reference DDI studies evaluating the effect of ritonavir at steady‐state on midazolam (CYP3A4 substrate) exposure. Midazolam AUC and Cmax ratios wer...
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Authors: Ken ‐ichi Umehara, Felix Huth, Christina S. Won, Tycho Heimbach, Handan He Tags: ORIGINAL PAPER Source Type: research
Issue Information
No abstract is available for this article. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - March 13, 2018 Category: Drugs & Pharmacology Tags: ISSUE INFORMATION Source Type: research
Potencies of Vitamin D Analogs, 1 α‐Hydroxyvitamin D3, 1α‐Hydroxyvitamin D2, and 25‐Hydroxyvitamin D3, in Lowering Cholesterol in Hypercholesterolemic Mice in vivo
Abstract
Vitamin D3 and the synthetic vitamin D analogs, 1α‐hydroxyvitamin D3 [1α(OH)D3] and 1α‐hydroxyvitamin D2 [1α(OH)D2], and 25‐hydroxyvitamin D3 [25(OH)D3] were appraised for their vitamin D receptor (VDR) associated‐potencies as cholesterol lowering agents in mice in vivo. These precursors require activation in vivo: 1α(OH)D3 and 1α(OH)D2 are activated by liver Cyp2r1 and Cyp27a1 to active VDR ligands, 1α,25‐dihydroxyvitamin D3 [1,25(OH)2D3] and 1α,25‐dihydroxyvitamin D2 [1,25(OH)2D2], respectively. 1α(OH)D2 may also be activated by Cyp24a1 to 1α,24‐dihydroxyvitamin D2 [1,24(OH)2D2], another ...
Source: Biopharmaceutics and Drug Disposition - February 27, 2018 Category: Drugs & Pharmacology Authors: Holly P. Quach, Tamara Dzekic, Paola Bukuroshi, K. Sandy Pang Tags: ORIGINAL PAPER Source Type: research
Differences in nonclinical pharmacokinetics between species and prediction of human pharmacokinetics of TAK ‐272 (SCO‐272), a novel orally active renin inhibitor
Biopharmaceutics&Drug Disposition,Volume 39, Issue 3, Page 175-183, March 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - February 23, 2018 Category: Drugs & Pharmacology Source Type: research
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Biopharmaceutics&Drug Disposition,Volume 39, Issue 3, Page 175-183, March 2018. (Source: Biopharmaceutics and Drug Disposition)
Source: Biopharmaceutics and Drug Disposition - February 23, 2018 Category: Drugs & Pharmacology Source Type: research
