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Contents
Publication date: January 2020Source: Anaesthesia & Intensive Care Medicine, Volume 21, Issue 1Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - January 17, 2020 Category: Anesthesiology Source Type: research

Editorial Board
Publication date: January 2020Source: Anaesthesia & Intensive Care Medicine, Volume 21, Issue 1Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - January 17, 2020 Category: Anesthesiology Source Type: research

Preoperative evaluation of neurosurgical patients
This article focuses on the required preoperative preparation of neurosurgical patients. Both intracranial and spinal surgery is associated with significant morbidity (22 % and 11 %, respectively). There is an overall estimated 30-day mortality risk of around 0.5% for spinal surgery, rising to 4.8 % for intracranial surgery. The most common complications include: the need for re-intervention, blood transfusion, pneumonia and urinary tract infection. Preoperative assessment must consider the surgical procedure being undertaken, pathology and its presentation, as well as patient related factors that can be optimized prior to...
Source: Anaesthesia and intensive care medicine - December 24, 2019 Category: Anesthesiology Source Type: research

Self-assessment
Publication date: Available online 19 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Viyayanand Nadella (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 20, 2019 Category: Anesthesiology Source Type: research

Acute management of ischaemic stroke
Publication date: Available online 19 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Deborah R. Douglas, Valpuri Luoma, Ugan ReddyAbstractAn acute ischaemic stroke (AIS) is a non-specific state of brain injury with neuronal dysfunction that has several pathophysiologic causes and is time critical. More than 70% of cases are due to thrombotic or embolic causes with resultant focal ischaemia and an accompanying neurological deficit. Initial assessment, stabilization and early imaging are important aspects of effective stroke management. Over the last two decades, thrombolysis and mechanical thrombectomy...
Source: Anaesthesia and intensive care medicine - December 20, 2019 Category: Anesthesiology Source Type: research

Clinical approach to comatose patients
Publication date: Available online 20 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Rosie May, Katharine HuntAbstractComa is a state of unarousable unconsciousness and can occur as result of many general medical and neurological conditions. In this article we present a structured approach to the investigation and management of a patient who presents with coma and discuss the importance of identifying the underlying cause in attempting to prevent secondary brain damage, as well as for prognostication. (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 20, 2019 Category: Anesthesiology Source Type: research

Pharmacological and pathological modulation of cerebral physiology
This article outlines how delivery of anaesthesia and disease processes affecting the brain modulate the mechanisms that regulate cerebral blood flow and metabolism. (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 19, 2019 Category: Anesthesiology Source Type: research

Anaesthesia for neurosurgery
Publication date: Available online 18 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Selina Ho, Oliver Hambidge, Robert JohnAbstractNeuroanaesthesia is an expanding specialty that requires a good understanding of neurophysiology as well as the pathophysiology of raised intracranial pressure. Neuroanaesthetists need to ensure neurosurgical patients maintain an adequate cerebral perfusion pressure intraoperatively, whist providing optimum operating conditions. To achieve this, a balanced anaesthetic technique preventing hypertensive surges and optimizing cerebral venous drainage by careful patient posit...
Source: Anaesthesia and intensive care medicine - December 19, 2019 Category: Anesthesiology Source Type: research

Ion channels, receptors, agonists and antagonists
This article describes the physiology of ion channels and the principal molecular mechanisms responsible for modulating their activity by commonly used drugs in anaesthesia and intensive care. The concept of efficient and selective transport of ions across ‘impermeable’ plasma membranes is introduced, together with the mechanisms influencing electrochemical signalling within cells. The classification and composition of voltage-gated ion channels are described in the context of their contribution to action potential generation in excitable cells. Drug–receptor interaction of the four main classes of receptor, that is,...
Source: Anaesthesia and intensive care medicine - December 19, 2019 Category: Anesthesiology Source Type: research

Prion diseases
Publication date: Available online 19 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Michelle LeemansAbstractThe prion diseases, or transmissible spongiform encephalopathies (TSEs), are a group of neurodegenerative diseases. They are caused by an abnormal form of a naturally occurring cellular protein, known as prion protein. All prion diseases are fatal and without cure. Although all are rare, interest has increased over the last 20 years due to the appearance of a new prion disease called variant Creutzfeldt-Jakob disease. This disease is transmissible via medical devices and blood and therefore has...
Source: Anaesthesia and intensive care medicine - December 19, 2019 Category: Anesthesiology Source Type: research

Contents
Publication date: December 2019Source: Anaesthesia & Intensive Care Medicine, Volume 20, Issue 12Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 17, 2019 Category: Anesthesiology Source Type: research

Editorial Board
Publication date: December 2019Source: Anaesthesia & Intensive Care Medicine, Volume 20, Issue 12Author(s): (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 17, 2019 Category: Anesthesiology Source Type: research

Cerebrospinal fluid and its physiology
This article describes the anatomy and physiology of CSF, and how abnormalities can result in hydrocephalus. (Source: Anaesthesia and intensive care medicine)
Source: Anaesthesia and intensive care medicine - December 13, 2019 Category: Anesthesiology Source Type: research

The management of spontaneous primary intracerebral haemorrhage
Publication date: Available online 12 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Christopher J. TaylorAbstractIntracerebral haemorrhage (ICH) accounts for around 10–20% of all strokes and results from a variety of disorders. ICH is more likely to result in death or major disability than ischaemic stroke or subarachnoid haemorrhage. Rapid imaging allows early diagnosis and characterization of the localization and severity of the haemorrhage. Patients with significant acute ICH should be managed in a critical care unit. Treatment entails general supportive care, control of blood pressure and intra...
Source: Anaesthesia and intensive care medicine - December 13, 2019 Category: Anesthesiology Source Type: research

Principles of intraoperative neurophysiological monitoring and anaesthetic considerations
Publication date: Available online 12 December 2019Source: Anaesthesia & Intensive Care MedicineAuthor(s): Brett Sanders, Santiago Catania, Astri MV. LuomaAbstractSurgery to the nervous system poses risks to neural structures be that mechanical, haemodynamical, chemical or thermal. The role of intraoperative neurophysiological monitoring (IONM) is to facilitate the assessment of the functional integrity of neural structures and provide a real time alerting system when changes caused by surgically induced insults are detected, with the goal of reducing the risk of postoperative neurological deficits. Furthermore, it is also...
Source: Anaesthesia and intensive care medicine - December 13, 2019 Category: Anesthesiology Source Type: research