Oral Health Inequalities in Africa and the Middle East
(Source: Advances in dental research)
Source: Advances in dental research - June 22, 2015 Category: Dentistry Authors: Honkala, E. Tags: Articles Source Type: research
Abstracts
(Source: Advances in dental research)
Source: Advances in dental research - April 15, 2014 Category: Dentistry Tags: Articles Source Type: research
Periodontal Disease, Atherosclerosis, Adverse Pregnancy Outcomes, and Head-and-Neck Cancer
Interrelationships between periodontal infection and systemic conditions such as cardiovascular disease, adverse pregnancy outcomes, and head-and-neck cancer have become increasingly appreciated in recent years. Periodontitis is associated with cardiovascular disease (CVD) and, experimentally, with measures of atherosclerosis and endothelial dysfunction. Periodontal therapy may reduce atherosclerotic changes and improve endothelial function. Preliminary findings suggest a role for the genetic locus ANRIL in the pathobiology of both CVD and periodontitis. Periodontal pathogens induce anticardiolipin in periodontitis patient...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Han, Y. W., Houcken, W., Loos, B. G., Schenkein, H. A., Tezal, M. Tags: Articles Source Type: research
Alveolar Bone Loss: Mechanisms, Potential Therapeutic Targets, and Interventions
This article reviews recent research into mechanisms underlying bone resorption and highlights avenues of investigation that may generate new therapies to combat alveolar bone loss in periodontitis. Several proteins, signaling pathways, stem cells, and dietary supplements are discussed as they relate to periodontal bone loss and regeneration. RGS12 is a crucial protein that mediates osteoclastogenesis and bone destruction, and a potential therapeutic target. RGS12 likely regulates osteoclast differentiation through regulating calcium influx to control the calcium oscillation-NFATc1 pathway. A working model for RGS10 and RG...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Intini, G., Katsuragi, Y., Kirkwood, K. L., Yang, S. Tags: Articles Source Type: research
Recent Advances in Host Defense Mechanisms/Therapies against Oral Infectious Diseases and Consequences for Systemic Disease
The innate and adaptive immune systems are both crucial to oral disease mechanisms and their impact on systemic health status. Greater understanding of these interrelationships will yield opportunities to identify new therapeutic targets to modulate disease processes and/or increase host resistance to infectious or inflammatory insult. The topics addressed reflect the latest advances in our knowledge of the role of innate and adaptive immune systems and inflammatory mechanisms in infectious diseases affecting the oral cavity, including periodontitis and candidiasis. In addition, several potential links with systemic inflam...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Gaffen, S. L., Herzberg, M. C., Taubman, M. A., Van Dyke, T. E. Tags: Articles Source Type: research
Novel Inflammatory Pathways in Periodontitis
New insights into the biological mechanisms involved in modulating periodontal inflammation and alveolar bone loss are paving the way for novel therapeutic strategies for periodontitis. The neutrophil adhesion cascade for transmigration in response to infection or inflammation is a key paradigm in immunity. Developmental endothelial locus-1 (Del-1) is one of several newly identified endogenous inhibitors of the leukocyte adhesion cascade. Del-1 competes with intercellular adhesion molecule-1 (ICAM-1) on endothelial cells for binding to the LFA-1 integrin on neutrophils, thereby regulating neutrophil recruitment and local i...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Hajishengallis, G., Sahingur, S. E. Tags: Articles Source Type: research
Genetic Characteristics and Pathogenic Mechanisms of Periodontal Pathogens
Periodontal disease is caused by a group of bacteria that utilize a variety of strategies and molecular mechanisms to evade or overcome host defenses. Recent research has uncovered new evidence illuminating interesting aspects of the virulence of these bacteria and their genomic variability. This paper summarizes some of the strategies utilized by the major species – Aggregatibacter actinomycetemcomitans, Tannerella forsythia, Treponema denticola, and Porphyromonas gingivalis – implicated in the pathogenesis of periodontal disease. Whole-genome sequencing of 14 diverse A. actinomycetemcomitans strains has revea...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Amano, A., Chen, C., Honma, K., Li, C., Settem, R. P., Sharma, A. Tags: Articles Source Type: research
Saliva-Microbe Interactions and Salivary Gland Dysfunction
Adequate salivary secretion is crucial to both oral and general health, since it provides a complex milieu for support of the microbial populations of the mouth, while at the same time containing antimicrobial products that help control these microbial populations. This paper summarizes several aspects of salivary component function, gland secretion mechanisms, and immunopathogenesis as related to oral health and disease. Salivary components mediate microbial attachment to oral surfaces, and also interact with planktonic microbial surfaces to facilitate agglutination and elimination of pathogens from the oral cavity. Adhes...
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Baker, O. J., Edgerton, M., Kramer, J. M., Ruhl, S. Tags: Articles Source Type: research
"Reflections"
(Source: Advances in dental research)
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Genco, R. J. Tags: Articles Source Type: research
Introduction to the Symposium Proceedings
(Source: Advances in dental research)
Source: Advances in dental research - April 15, 2014 Category: Dentistry Authors: Scannapieco, F. Tags: Articles Source Type: research
Erratum
Ellwood RP, Goma J, Pretty IA (2012). Caries clinical trial methods for the assessment of oral care products in the 21st century. Adv Dent Res 24:32-35. (Original DOI: 10.1177/0022034512449464) (Source: Advances in dental research)
Source: Advances in dental research - October 15, 2013 Category: Dentistry Tags: Articles Source Type: research
Priorities for Future Innovation, Research, and Advocacy in Dental Restorative Materials
Innovations in materials science, both within and outside of dentistry, open opportunities for the development of exciting direct restorative materials. From rich dialog among experts from dental and non-dental academic institutions and industry, as well as those from policy, research funding, and professional organizations, we learned that capitalizing on these opportunities is multifactorial and far from straightforward. Beginning from the point when a restoration is needed, what materials, delivery systems, and skills are needed to best serve the most people throughout the world’s widely varied economic and infras...
Source: Advances in dental research - October 15, 2013 Category: Dentistry Authors: Watson, T., Fox, C. H., Rekow, E. D. Tags: Articles Source Type: research
Ensuring the Global Availability of High-quality Dental Restorative Materials
The Minamata Convention, a global legally binding instrument (treaty) on mercury, has been the catalyst for the emerging agenda on global dental materials research. If the current and future challenges of oral health maintenance and healing on a global scale are to be met, a logical and effective research agenda for the discovery and introduction of new, environmentally sustainable, dental materials must be developed through a coordinated effort involving materials scientists, dental clinicians, representatives of industry, members of regional and national regulatory bodies, and advocacy from research organizations. For un...
Source: Advances in dental research - October 15, 2013 Category: Dentistry Authors: Ferracane, J., Fisher, J., Eisele, J. L., Fox, C. H. Tags: Articles Source Type: research
Incorporating New Materials and Techniques into Clinical Practice
This article outlines the subjects presented and discussed at the December 2012 IADR Dental Materials Innovation Workshop held at King’s College London. Incorporating new materials and techniques into clinical practice was considered from 4 perspectives: (1) Accelerating the "research to regulatory approval" process was presented with current developments in the United States, with the National Institutes of Health/Food and Drug Administration process as a working example; (2) intellectual property and regulatory requirements were discussed across the well-established US and EU frameworks, as well as the more recentl...
Source: Advances in dental research - October 15, 2013 Category: Dentistry Authors: Pitts, N. B., Drummond, J., Guggenberger, R., Ferrillo, P., Johnston, S. Tags: Articles Source Type: research
Outside-the-(Cavity-prep)-Box Thinking
Direct placement restorative materials must interface with tooth structures that are often compromised by caries or trauma. The material must seal the interface while providing sufficient strength and wear resistance to assure function of the tooth for, ideally, the lifetime of the patient. Needed are direct restorative materials that are less technique-sensitive than current resin-based composite systems while having improved properties. The ideal material could be successfully used in areas of the world with limited infrastructure. Advances in our understanding of the interface between the restoration adhesive system and...
Source: Advances in dental research - October 15, 2013 Category: Dentistry Authors: Thompson, V. P., Watson, T. F., Marshall, G. W., Blackman, B. R. K., Stansbury, J. W., Schadler, L. S., Pearson, R. A., Libanori, R. Tags: Articles Source Type: research
