Health benefits of intensive blood pressure control outweigh a slight risk of developing kidney disease
A new study found that in people who do not have chronic kidney disease (CKD), an intensive blood pressure control regimen increases risk of declining kidney function; this risk is generally outweighed by a reduced risk for cardiovascular events and death. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
New insights on risk factors for severe hypoglycemia in people with type 2 diabetes
Results of NIDDK-supported research have improved understanding of factors that can help predict vulnerability to severe hypoglycemia in African American and white individuals with type 2 diabetes. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Understanding how cells in the pancreas change with age
Researchers have used sophisticated technologies to examine individual cells from healthy human pancreata to understand how the cells change with age. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
A tale of two sugars —fructose and glucose cause differing metabolic effects
Researchers have found that the sugars fructose and glucose cause different metabolic effects and health outcomes in mice, but only in animals eating a high-fat diet. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Restricted feeding leads to metabolic benefits in mice
Scientists found that feeding mice twice a day, with complete food restriction in between, improved metabolism and prevented age- and obesity-associated metabolic defects compared to allowing them 24-hour access to food. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Bacterial enzyme implicated in inflammatory bowel disease
Using human samples and animal models, researchers have found that an enzyme produced by certain bacteria could disrupt the gut microbiome, potentially playing a significant role in the development of inflammatory bowel disease. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Turning pancreatic alpha cells into insulin-producing beta-like cells via gene therapy
Scientists have developed a new way to replace lost beta cells in mouse models of type 1 diabetes. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Microbial “irony”—bacteria provide keys to battling urinary tract infections
Researchers have identified two different molecules that can limit growth of microbes that cause urinary tract infections (UTIs), adding to approaches being pursued to develop new strategies for clinical treatment of UTIs. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Genes newly associated with body weight
Scientists ’ recent analysis of hundreds of thousands of human genomes has identified new links between certain gene sequence variations and body mass index (BMI), a measure of weight relative to height. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
“Sensing” a genetic predisposition to obesity
New research suggests a mechanism by which antenna-like sensory projections, called primary cilia, located on brain cells play a role in the genetic predisposition to and development of obesity. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Becoming unglued: how a genetic variant may affect the gut barrier and contribute to inflammatory bowel disease
Researchers have found that a genetic variant may impart risk for inflammatory bowel disease (IBD) by disrupting the cellular “glue” that keeps the gut’s lining intact. (Source: NIDDK News)
Source: NIDDK News - June 26, 2018 Category: Endocrinology Source Type: news
Shedding Light on the Functional Genetic Architecture of Inflammatory Bowel Disease
Recent findings have uncovered two genetic variants that increase the risk for inflammatory bowel disease and also provided clues to their function. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news
Finding the Genetic Cause of a Form of Hyperparathyroidism
Researchers have identified genetic differences that can cause familial isolated hyperparathyroidism. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news
The Sweet Smell of Success —A Protein in the Kidney Helps the Body Retain Sugar
Scientists identified a protein in the mouse kidney that helps prevent the body from excreting glucose. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news
Dynamic Bladder and Bacterial Changes Hold Clues to Therapies
In two recent studies, researchers delved into changes that occur in the bladder and invading bacteria that affect both acute and recurrent infection. (Source: NIDDK News)
Source: NIDDK News - June 23, 2018 Category: Endocrinology Source Type: news
