Research Identifies Key Hurdle in Quest for Cystic Fibrosis Treatment
Research offers important insight for new drug therapy to restore proper CFTR folding/function in most with cystic fibrosis, those with the ?F508 mutation. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Reducing Sugary Drinks Could Reduce Obesity
Studies support a link between consumption of sugar-sweetened beverages and excess weight gain and suggest potential target behavior for obesity prevention. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Long-range Regulation of How Genes are Turned “Off” and “On”
Two studies increased understanding of transcriptional regulation of some red blood cell genes and how they turn on/off; may help in treating blood diseases. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
LiverTox: A New Online Resource for Information on Drug-induced Liver Injury
LiverTox is a web-based resource for information on drug-induced liver injury from prescription and OTC drugs, and complementary and alternative medicines. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Kidney Damage: New Insights into Initiation, New Targets for Therapy
Five studies of the complex system of regulation in kidney fibrosis following injury identified potential targets to prevent or reverse kidney fibrosis. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Gut Microbes Transmit Susceptibility to Nonalcoholic Fatty Liver Disease Progression
Studies have expanded understanding of the role of gut microbes in nonalcoholic fatty liver disease (NAFLD) progression to nonalcoholic steatohepatitis (NASH). (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Genetic Variants Linked to Earlier Kidney Failure in African Americans
African Americans with APOL1 gene experience faster rate of decline in kidney function and begin hemodialysis at a younger age versus those without the gene. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Dr. Peter P. Reese and Dr. Georgios Skiniotis: NIDDK-Supported Scientists Receive Presidential Award
Drs. Peter Reese and Georgios Skiniotis received the 2011 PECASE for their work in organ transplant research and signaling surface receptors, respectively. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Alpha-1 Antitrypsin Deficiency —From Genes to Therapies
NIH funded research has identified genetic factors and clinical manifestations of alpha-1 antitrypsin deficiency which may lead to future treatments. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
A Time to Sleep and a Time to Metabolize
Studying the role of factors such as Rev-erbs and HDAC3 in circadian control of metabolism may lead to behavioral strategies to prevent metabolic disease. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
A Dramatic Improvement in Care for Some People with Cystic Fibrosis
Years of research led to a new medication to overcome the fundamental molecular flaw in some people with cystic fibrosis, greatly reducing their symptoms. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Discoveries May Improve Treatment of Mucopolysaccharidosis
Binding therapeutic enzymes that can cross the blood-brain barrier and use of anti-inflammatory drugs may improve treatment of mucopolysaccharidosis symptoms. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Mouse Model Provides New Insight into Bladder Control
Scientists discovered a protein in the urothelium of mice that helps them control their bladders which could lead to treatments for human urinary incontinence. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
New Function Identified for Odor Receptors
Scientists discovered seven transmembrane receptors in mice that are sensitive to gut microbial metabolism and the regulation of blood pressure. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
Deterioration in Heart Function Associated with Progression to Kidney Failure
As patient's progress from chronic kidney disease to kidney failure, ventricular hypertrophy was stable but the heart ’s ejection fraction efficiency decreased. (Source: NIDDK News)
Source: NIDDK News - March 15, 2018 Category: Endocrinology Source Type: news
