mRNA vaccines slash risk of COVID-19 infection by 91% in fully vaccinated people
(University of Utah Health) People who receive mRNA COVID-19 vaccines are up to 91 percent less likely to develop the disease than those who are unvaccinated, according to a new nationwide study of eight sites, including Salt Lake City. For those few vaccinated people who do still get an infection, or " breakthrough " cases, the study suggests that vaccines reduce the severity of COVID-19 symptoms and shorten its duration. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Diabetes care, glycemic control during pandemic in US
(JAMA Network) What The Study Did: Rates at which patients with type 2 diabetes received diabetes-related health services prior to and during the COVID-19 pandemic are compared in this study. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Evaluation of messenger RNA from COVID-19 vaccines in human milk
(JAMA Network) What The Study Did: COVID-19 vaccine-associated messenger RNA (mRNA) wasn't detected in 13 human milk samples collected after vaccination from seven breastfeeding mothers. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Seroprevalence, risk factors associated with SARS-CoV-2 infection in health care workers in Italy early in pandemic
This study in the Lombardy region of Italy examined the association of different health care professional categories and operational units, including in-hospital wards and outpatient facilities, with the seroprevalence of positive IgG antibody tests for SARS-CoV-2 and the likelihood of SARS-CoV-2 infection. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Epsilon variant mutations contribute to COVID immune evasion
(University of Washington School of Medicine/UW Medicine) Three mutations in the Epsilon coronavirus spike protein dampen the neutralizing potency of antibodies induced by current vaccines or past COVID infections. The mutations give this coronavirus variant of concern a means to totally evade specific monoclonal antibodies used in clinics and reduce the effectiveness of antibodies from plasma of vaccinated people. The latest molecular exploration of the mutation-remodeled configuration of the coronavirus infection machinery shows that the Epsilon variant relies on an indirect and unusual neutralization-escape strategy. (S...
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

SARS-CoV-2 encoded miRNA is a biomarker for stratification of severe patients
(Nanjing University School of Life Sciences) The multi-centre study identified a microRNA-like small RNA encoded by SARS-CoV-2 in the serum of COVID-19 patients, which can be developed as a non-invasive biomarker for stratification of severe patients from mild/moderate ones and for identification of high-risk individuals before clinical manifestation of severe symptoms. This biomarker ensures proper allocation of patients to different levels of medical facilities and allows more effective control of the pandemic and relief of social economic burdens. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Chemo upsets gut health in cancer patients
(Flinders University) New research has shown myelosuppressive chemotherapy destabilises gut microbiome in patients with solid organ cancers. The study from SAHMRI and Flinders University assessed the gut health of men and women who underwent conventional chemotherapy on cancers, such as breast and lung cancer, without exposure to antibiotics. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

AID/APOBECs among important factors in body's defence against SARS-CoV-2
(Medical University of Vienna) Activation-induced cytidine deaminase (AID) and so-called APOBEC proteins are important factors in the body's immune response and offer fast and effective protection against a large number of DNA and RNA viruses. A MedUni Vienna research team has now addressed the potential interrelations between AID/APOBECs and the SARS-CoV-2 virus. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 6, 2021 Category: Infectious Diseases Source Type: news

Combating infectious diseases with genetic engineering
(University of Erlangen-Nuremberg) As part of the drive to support junior research groups in research into infectious diseases, the Federal Ministry of Education and Research is to provide 2,162,188 euros in funding from 2021 to 2026 for the research project 'AGEnTS - Genetic Engineering of T-cells for Treating Infectious Diseases' at Friedrich-Alexander University Erlangen-N ü rnberg (FAU). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

Modelling COVID-19 cases in Africa
(Lancaster University) An international team including Lancaster University researchers has created a strategy for understanding the evolution of the COVID-19 pandemic throughout the African continent. Their COVID-19 surveillance strategy will improve the ability of African countries to interpret the complex data available to them during the pandemic. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

Study shows laboratory developed protein spikes consistent with COVID-19 virus
(University of Southampton) Key to designing COVID-19 antibody tests and vaccines is the manufacture of protein " spikes " which mimic those on the infectious virus, triggering our immune systems into action. The spikes on the SARS-CoV-2 virus are coated in glycans, which they use to disguise themselves from the human immune system. The abundance of these glycans could potentially create discrepancies between studies using different spikes.Reassuringly, a new study reveals minimal variations in recombinant spikes from five laboratories. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

COVID gets quantum treatment for drug discovery
(University of Texas at Austin, Texas Advanced Computing Center) Oak Ridge National Laboratory researchers are using TACC's Stampede2 to help refine screening of potential drug molecules against COVID-19.Stephan Irle and Van Quan Vuong of ORNL developed the quantum mechanics-based ranking refinement and binding analysis run on Stampede2 that narrowed from 3,000 to 100 of the most promising drug compounds for further study. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

Asymptomatic adults may be reservoirs of Streptococcus pneumoniae
(Instituto de Tecnologia Qu í mica e Biol ó gica Ant ó nio Xavier da Universidade NOVA de Lisboa ITQB NOVA) In Europe, S. pneumoniae is the most common cause of community-acquired bacterial pneumonia in adults. Still, very little is known about its colonization within this age group. A team of researchers from ITQB NOVA has now taken a crucial step to clarify the dynamics of carriage of this bacterium in adults. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

COVID-19 news from Annals of Internal Medicine
(American College of Physicians) A retrospective cohort study found that surges in hospital COVID-19 caseload significantly increased mortality in the hardest hit U.S. hospitals. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news

Infusion centers associated with substantially better outcomes than the ER for patients with acute pain events and sickle cell disease
(American College of Physicians) A prospective cohort study found that treatment at an infusion center (IC) is associated with substantially better outcomes than treatment in the emergency department (ED) for patients with sickle cell disease (SCD) and uncomplicated vaso-occlusive crises. The findings are published in Annals of Internal Medicine. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - July 5, 2021 Category: Infectious Diseases Source Type: news