Skin Lesions on a 12-Year-Old Patient
A 12-year-old boy presents with numerous itchy skin lesion on his arms. What is your diagnosis? (Source: Cancer Network)
Source: Cancer Network - September 23, 2013 Category: Cancer & Oncology Source Type: news

Married Individuals Less Likely to Be Diagnosed With Advanced Cancer
A large study shows a difference in the cancer outcomes of married and unmarried individuals, finding that those who are married are less likely to be diagnosed with metastatic disease and to die of their cancer compared with those who are unmarried. (Source: Cancer Network)
Source: Cancer Network - September 23, 2013 Category: Cancer & Oncology Source Type: news

Impact of Screening on Early- and Late-Stage Colorectal Cancers
A study on screening colonoscopy for colorectal cancers, originally presented at ASCO 2013, found that from 1976 to 2009 late-stage cancer incidence decreased from 117 to 74 cases per 100,000 people, and early-stage incidence decreased from 77 to 68 cases per 100,000. (Source: Cancer Network)
Source: Cancer Network - September 22, 2013 Category: Cancer & Oncology Source Type: news

Inherited Mutation Linked to Development of Pediatric ALL
A mutation of the PAX5 gene has been found to play an important role in inherited cases of B-cell precursor acute lymphoblastic leukemia (B-ALL). The mutation was isolated in two unrelated families with high propensity for B-ALL. (Source: Cancer Network)
Source: Cancer Network - September 21, 2013 Category: Cancer & Oncology Source Type: news

FDA Priority Review for Metastatic Melanoma Oral Combination
The combination of two oral targeted agents, dabrafenib (Tafinlar) and trametinib (Mekinist), has been given a priority review by the FDA for the treatment of BRAF V600-positive metastatic melanoma. (Source: Cancer Network)
Source: Cancer Network - September 20, 2013 Category: Cancer & Oncology Source Type: news

No Survival Benefit With Ipilimumab in Advanced Prostate Cancer
In a phase III trial, ipilimumab increased the overall survival of men with advanced castration-resistant prostate cancer when used with a single dose of radiotherapy by 1.2 months, but the results were not statistically significant. (Source: Cancer Network)
Source: Cancer Network - September 20, 2013 Category: Cancer & Oncology Source Type: news

Vaccination Shows No Benefit for Primary Melanomas
The use of GM2-KLH/QS-21 vaccination in stage II melanoma patients did not improve outcomes, according to the results of the EORTC 18961 phase III trial. (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

Chemo Education Classes Empower Patients
At ONS Congress 2013, Peggy Scott explains how chemotherapy education classes at The Emily Couric Cancer Center, now in place for 2 years, have put patients at the center of their care and prepared them to start treatment (abstract 129532). (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

A 63-Year-Old Patient Presents With Significant Dyspnea
A 63-year-old woman comes to your office with significant dyspnea. You obtain a chest x-ray which is shown here. What is the best next step in management? (Source: Cancer Network)
Source: Cancer Network - September 19, 2013 Category: Cancer & Oncology Source Type: news

NDA Filed for Idelalisib for Treating Non-Hodgkin Lymphoma
Gilead Sciences has submitted an NDA to the FDA for its new drug idelalisib, for the use in patients with indolent non-Hodgkin lymphoma that is refractory to rituximab and chemotherapy. (Source: Cancer Network)
Source: Cancer Network - September 18, 2013 Category: Cancer & Oncology Source Type: news

Nurse-Led Care Coordination After Colorectal Cancer Surgery Failed to Show Effect
The use of a centralized nurse-led telephone-based care coordination system failed to improve outcomes including quality of life, unmet supportive needs or visits to the emergency department after surgical resection of colorectal cancer, according to the results of a new study. (Source: Cancer Network)
Source: Cancer Network - September 18, 2013 Category: Cancer & Oncology Source Type: news

MicroRNAs Regulate Small-Cell Lung Cancer Bone Metastasis
Researchers have identified a novel pathway that promotes bone metastasis of small-cell lung cancer (SCLC). The study is in mice, but points to a potential target that could be exploited to control or prevent metastatic disease. (Source: Cancer Network)
Source: Cancer Network - September 17, 2013 Category: Cancer & Oncology Source Type: news

Pomalidomide With Low-Dose Dexamethasone New Treatment Option for Multiple Myeloma
Pomalidomide, an immunomodulatory drug, combined with low-dose dexamethasone improved progression-free survival in patients with refractory or relapsed and refractory multiple myeloma compared with standard of care high-dose dexamethasone, according to a new study. (Source: Cancer Network)
Source: Cancer Network - September 17, 2013 Category: Cancer & Oncology Source Type: news

Tivozanib Fails to Show Overall Survival Difference in Metastatic RCC
The results of the study comparing Aveo’s tivozanib to sorafenib for the treatment of metastatic renal cell carcinoma showed no improvement in overall survival, the basis for the FDA’s rejection of the company’s new drug application earlier this year. (Source: Cancer Network)
Source: Cancer Network - September 16, 2013 Category: Cancer & Oncology Source Type: news

Triple-Negative Breast Cancer Tumor Stroma Plays Big Role in Bone Metastases
In order for malignancies to establish in metastatic sites, cancer cells must acquire attributes of those sites; specifically how this occurs in many cancers is relatively unknown, but a new study implicates the stroma of certain breast cancer tumors in the development of bone metastases. (Source: Cancer Network)
Source: Cancer Network - September 16, 2013 Category: Cancer & Oncology Source Type: news